Abstract
Purpose of Review
To provide pathophysiological and clinical insights into the effects of sacubitril/valsartan on glomerular function.
Recent Findings
Heart failure and glomerular dysfunction are closely intertwined. In addition to reduced heart failure hospitalization and all-cause mortality, patients treated with sacubitril/valsartan have a slower deterioration of glomerular filtration rate over time compared with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers.
Summary
The effects of sacubitril/valsartan are probably mediated through enhancement of natriuretic peptides, reduction of glomerular inflammation and fibrosis, and relaxation of mesangial cells and podocytes. Further studies will elucidate underlying pathophysiological mechanisms of sacubitril/valsartan on glomerular function and their prognostic significance in subjects with and without heart failure.
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Funding
Jeroen Dauw, Pieter Martens, and Wilfried Mullens are researchers for the Limburg Clinical Research Center (LCRC) UHasselt-ZOL-Jessa, supported by the foundation Limburg Sterk Merk (LSM), province of Limburg, Flemish government, Hasselt University, Ziekenhuis Oost-Limburg, and Jessa Hospital.
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Tersalvi, G., Dauw, J., Martens, P. et al. Impact of Sacubitril-Valsartan on Markers of Glomerular Function. Curr Heart Fail Rep 17, 145–152 (2020). https://doi.org/10.1007/s11897-020-00463-1
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DOI: https://doi.org/10.1007/s11897-020-00463-1