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Review of Secondary Causes of Osteoporotic Fractures Due to Diabetes and Spinal Cord Injury

  • Orthopedic Management of Fractures (M Kacena and L Gerstenfeld, Section Editors)
  • Published:
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Abstract

Purpose of Review

The aim of this review is to gain a better understanding of osteoporotic fractures and the different mechanisms that are driven in the scenarios of bone disuse due to spinal cord injury and osteometabolic disorders due to diabetes.

Recent Findings

Despite major advances in understanding the pathogenesis, prevention, and treatment of osteoporosis, the high incidence of impaired fracture healing remains an important complication of bone loss, leading to marked impairment of the health of an individual and economic burden to the medical system.

Summary

This review underlines several pathways leading to bone loss and increased risk for fractures. Specifically, we addressed the different mechanisms leading to bone loss after a spinal cord injury and diabetes. Finally, it also encompasses the changes responsible for impaired bone repair in these scenarios, which may be of great interest for future studies on therapeutic approaches to treat osteoporosis and osteoporotic fractures.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Authors and Affiliations

  1. Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil

    Ariane Zamarioli & José B. Volpon

  2. Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA

    Caio de Andrade Staut

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  1. Ariane Zamarioli
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  2. Caio de Andrade Staut
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  3. José B. Volpon
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Correspondence to Ariane Zamarioli.

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This article is part of the Topical Collection on Orthopedic Management of Fractures.

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Zamarioli, A., de Andrade Staut, C. & Volpon, J.B. Review of Secondary Causes of Osteoporotic Fractures Due to Diabetes and Spinal Cord Injury. Curr Osteoporos Rep 18, 148–156 (2020). https://doi.org/10.1007/s11914-020-00571-w

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