Abstract
Pediatric-onset mixed connective tissue disease is among the rare disease entities in pediatric rheumatology and includes features of arthritis, polymyositis/dermatomyositis, systemic lupus erythematosus, and systemic sclerosis. Accurate recognition and diagnosis of the disease is paramount to prevent long-term morbidity. Advances in the genetic and immunologic understanding of the factors involved in the etiopathogenesis provide an opportunity for improvements in prognostication and targeted therapy. The development of a multinational cohort of patients with mixed connective tissue disease would be invaluable to provide more updated data regarding the clinical presentation, to develop a standardized treatment approach, disease activity and outcome tools, and to provide data on long-term outcomes and comorbidities.
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Berard, R.A., Laxer, R.M. Pediatric Mixed Connective Tissue Disease. Curr Rheumatol Rep 18, 28 (2016). https://doi.org/10.1007/s11926-016-0576-x
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DOI: https://doi.org/10.1007/s11926-016-0576-x