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A Neuro-Comparative Study between Single/Successive Thorium Dose Intoxication and Alginate Treatment

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Abstract

The adult male albino rats were grouped into five groups (control group and four variably treated groups with thorium (Th) in single or successive with or without alginate treatment). The IP administration of thorium nitrate (13.6 mg/kg b.wt.) induced a regional distribution and accumulation ordered as cerebellum > cerebral cortex > brain stem > hippocampus > hypothalamus > striatum. Also, it induces a significant increase in Na+, Ca2+, and Fe3+ ion content and malondialdehyde (MDA) level while K+ ions and glutathione (GSH) level were significantly decreased. On the other hand, the daily oral administration of 5% alginate showed a significant decreasing in the accumulation of thorium in the different brain areas and mitigated its hazardous effects. By the alginate treatment, Na+, Ca2+, Fe3+, and level of MDA were declined while K+ ions and GSH level showed a significant increase. The improvement of the investigated parameters was attributed to the specific chelating, regeneration, and antioxidant properties of the alginate. So, alginate administration could ameliorate the hazardous effects of thorium nitrate.

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Acknowledgements

I am indebted forever with sincere gratitude and thanks to Prof. Dr. Tarek Fahmy Mohammedan Professor of Geochemistry Nuclear Material Authority, for his patience, motivation, enthusiasm, and counseling encouragement to me.

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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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  1. Isotopes Department, Nuclear Materials Authority, Cairo, Egypt

    Mohamed M. Rezk

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Correspondence to Mohamed M. Rezk.

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The investigation protocol was approved by the ethics committee of nuclear material authority, which is performed in accordance with the ethical standards laid down in the US guidelines (NIH Publication no. 85-23, amended in 1985).

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The author declares that he has no conflict of interest.

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Rezk, M.M. A Neuro-Comparative Study between Single/Successive Thorium Dose Intoxication and Alginate Treatment. Biol Trace Elem Res 185, 414–423 (2018). https://doi.org/10.1007/s12011-018-1262-9

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