Abstract
It is rapidly increasing to have selenium (Se) supplementation for urban elderly population in China since they are facing a widespread deficiency daily Se intake. However, until now, there is no low-cost, non-invasive, rapid, and reliable method to monitor the health improvement or risk for elderly Se-supplemented population in China. The present cross-sectional study (229 participants with older than 55 years old) performed in Beijing, China, revealed that the Se concentrations of non-supplementer users (n = 27) were 55 ± 23 μg/L in urine, 139.9 ± 102.3 μg/L in serum, and 487.6 ± 158.7 μg/kg in hair. But a significant increase on hair Se concentrations (615.4 ± 238.8 μg/kg) was observed for Se supplementer users (n = 202) (p < 0.05); there were no significant statistical differences in serum and urine between the Se-supplemented (n = 202) and Se non-supplemented groups (n = 27). This indicated the hair Se levels could be a more sensitive biomarker for Se-supplemented elderly population. Participants who consumed Se supplements for 7–12 months had the highest Se status based on hair and serum Se concentrations (p < 0.05). The present study also revealed that most elderly adults in Beijing just need to supplement 50 μg Se per day to achieve Se plateau status. Furthermore, hair Se levels were positively related with triglycerides/TG levels (p < 0.05) but not body mass index/BMI, total cholesterol/TC, and low-density lipoprotein cholesterol/LDL, implicating Se supplementation for Se sufficiency baseline in elderly population in Beijing likely posed health risk, especially on TG because of excessive Se oxidation stress. An ongoing monitoring of Se status via hair is still warranted to prevent future Se deficiency or excess in China.
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References
Schomburg L (2012) Selenium, selenoproteins and the thyroid gland: interactions in health and disease. Nat Rev Endocrinol 8(3):160–171
Rayman MP (2012) Selenium and human health. Lancet 379(9822):1256–1268
Avery JC, Hoffmann PR (2018) Selenium, selenoproteins, and immunity. Nutrients 10(9):1203
Rayman MP (2000) The importance of selenium to human health. Lancet 356(9225):233–241
Keshan Disease Research Group (1979) Observations on effect of sodium selenite in prevention of Keshan disease. Chin Med J (Engl) 92(7):471–476
Keshan Disease Research Group (1979) Epidemiologic studies on the etiologic relationship of selenium and Keshan disease. Chin Med J (Engl) 92(7):477–482
Liu H, Yu F, Shao W, Ding D, Yu Z, Chen F, Geng D, Tan X, Lammi MJ, Guo X (2018) Associations between selenium content in hair and Kashin-Beck disease/Keshan disease in children in Northwestern China: a prospective cohort study. Biol Trace Elem Res 184(1):16–23
Levander O (1987) Etiological hypotheses concerning Kashin-Beck disease. In: American Institute of Nutrition Symposium Proceedings. American Institute of Nutrition, Bethesda, pp 67–71
Xiong YM, Mo XY, Zou XZ, Song RX, Sun WY, Lu W, Chen Q, Yu YX, Zang WJ (2010) Association study between polymorphisms in selenoprotein genes and susceptibility to Kashin-Beck disease. Osteoarthritis Cartilage 18(6):817–824
Beck MA, Handy J, Levander OA (2004) Host nutritional status: the neglected virulence factor. Trends Microbiol 12(9):417–423
Wu Q, Rayman MP, Lv H, Schomburg L, Cui B, Gao C, Chen P, Zhuang G, Zhang Z, Peng X, Li H, Zhao Y, He X, Zeng G, Qin F, Hou P, Shi B (2015) Low population selenium status is associated with increased prevalence of thyroid disease. J Clin Endocrinol Metab 100(11):4037–4047
Akbaraly TN, Hininger-Favier I, Carrière I, Arnaud J, Gourlet V, Roussel AM, Berr C (2007) Plasma selenium over time and cognitive decline in the elderly. Epidemiology 18(1):52–58
Rayman MP, Stranges S (2013) Epidemiology of selenium and type 2 diabetes: can we make sense of it? Free Radic Biol Med 65:1557–1564
Duffield-Lillico AJ, Reid ME, Turnbull BW, Combs GF Jr, Slate EH, Fischbach LA, Marshall JR, Clark LC (2002) Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial. Cancer Epidemiol Biomarkers Prev 11(7):630–639
Li S, Bañuelos GS, Wu L, Shi W (2014) The changing selenium nutritional status of Chinese residents. Nutrients 6(3):1103–1114
Dinh QT, Cui Z, Huang J, Tran TAT, Wang D, Yang W, Zhou F, Wang M, Yu D, Liang D (2018) Selenium distribution in the Chinese environment and its relationship with human health: a review. Environ Int 112:294–309
Yang XE, Chen WR, Feng Y (2007) Improving human micronutrient nutrition through biofortification in the soil-plant system: China as a case study. Environ Geochem Health 29(5):413–428
Wu Z, Bañuelos GS, Lin ZQ, Liu Y, Yuan L, Yin X, Li M (2015) Biofortification and phytoremediation of selenium in China. Front Plant Sci 6:136
Long J, Luo K (2017) Trace element distribution and enrichment patterns of Ediacaran-early Cambrian, Ziyang selenosis area, Central China: constraints for the origin of Selenium. J Geochem Explor 172:211–230
Wang R, Yu T, Zeng QL, Yang ZF (2017) Distribution characteristics, origin and influencing factors of soil selenium concentration of main farming areas in China. Current Biotechnology 7(5):359–366 (In Chinese with English abstract)
Huang S, Hua M, Feng J, Zhong X, Jin Y, Zhu B, Lu H (2009) Assessment of selenium pollution in agricultural soils in the Xuzhou District, Northwest Jiangsu, China. J Environ Sci 21(4):481–487
Sun GX, Meharg AA, Li G, Chen Z, Yang L, Chen SC, Zhu YG (2016) Distribution of soil selenium in China is potentially controlled by deposition and volatilization? Sci Rep 6:20953
Tan JA (1989) The atlas of endemic diseases and their environments in the People’s Republic of China. Science Press, China (In Chinese)
Tan J, Zhu W, Wang W, Li R, Hou S, Wang D, Yang L (2002) Selenium in soil and endemic diseases in China. Sci Total Environ 284(1-3):227–235
Liu Z, Zhao L, Man Q, Wang J, Zhao W, Zhang J (2019) Dietary micronutrients intake status among Chinese elderly people living at home: data from CNNHS 2010-2012. Nutrients 11(8):1787
Chinese Nutrition Society (2000) Chinese dietary reference intakes. China Light Industry Press, Beijing, pp 210–225 (In Chinese)
Chinese Nutrition Society (2014) Chinese dietary reference intakes (2013 version). Science Press, Beijing, China, pp 250–257 (In Chinese)
Alfthan G, Xu GL, Tan WH, Aro A, Wu J, Yang YX, Liang WS, Xue WL, Kong LH (2000) Selenium supplementation of children in a selenium-deficient area in China. Biol Trace Elem Res 73(2):113–125
Sun LY, Meng FG, Li Q, Zhao ZJ, He CZ, Wang SP, Sa RL, Man WW, Wang LH (2014) Effects of the consumption of rice from non-KBD areas and selenium supplementation on the prevention and treatment of paediatric Kaschin-Beck disease: an epidemiological intervention trial in the Qinghai Province. Osteoarthritis Cartilage 22(12):2033–2040
Zhang R, Xu YF, Li YH, Li HR (2019) Se nutrition and elderly health. Chinese Journal of Gerontology 3:1256–1258 (In Chinese with English abstract)
Lu X, He Z, Lin Z, Zhu Y, Yuan L, Liu Y, Yin X (2018) Effects of Chinese cooking methods on the content and speciation of selenium in selenium bio-fortified cereals and soybeans. Nutrients 10(3):317
Ashton K, Hooper L, Harvey LJ, Hurst R, Casgrain A, Fairweather-Tait SJ (2009) Methods of assessment of selenium status in humans: a systematic review. Am J Clin Nutr 89(6):2025S–2039S
Cai Z, Zhang J, Li H (2019) Selenium, aging and aging-related diseases. Aging Clin Exp Res 31(8):1035–1047
Combs GF Jr (2015) Biomarkers of selenium status. Nutrients 7(4):2209–2236
Phiri FP, Ander EL, Lark RM, Bailey EH, Chilima B, Gondwe J, Joy EJM, Kalimbira AA, Phuka JC, Suchdev PS, Middleton DRS, Hamilton EM, Watts MJ, Young SD, Broadley MR (2020) Urine selenium concentration is a useful biomarker for assessing population level selenium status. Environ Int 134:105218
El-Demerdash FM, Nasr HM (2014) Antioxidant effect of selenium on lipid peroxidation, hyperlipidemia and biochemical parameters in rats exposed to diazinon. J Trace Elem Med Biol 28(1):89–93
Seale LA, Hashimoto AC, Kurokawa S, Gilman CL, Seyedali A, Bellinger FP, Raman AV, Berry MJ (2012) Disruption of the selenocysteine lyase-mediated selenium recycling pathway leads to metabolic syndrome in mice. Mol Cell Biol 32(20):4141–4154
Su LQ, Gao SJ, Unverzagt FW, Cheng YB, Hake AM, Xin PJ, Chen C, Liu JY, Ma F, Bian JC, Li P, Jin YL (2015) Selenium level and dyslipidemia in rural elderly Chinese. PLoS ONE 10(9):e0136706. https://doi.org/10.1371/journal.pone.0136706
Fülöp P, Seres I, Jenei Z, Juhász I, Paragh G (2013) Increased hair selenium concentration in hyperlipidemic patients. J Cell Mol Med 17(3):350–355
Hulsmans M, Holvoet P (2010) The vicious circle between oxidative stress and inflammation in atherosclerosis. J Cell Mol Med 14:70–78
Obeid O, Elfakhani M, Hlais S, Iskandar M, Batal M, Mouneimne Y, Adra N, Hwalla N (2008) Plasma copper, zinc, and selenium levels and correlates with metabolic syndrome components of Lebanese adults. Biol Trace Elem Res 123(103):58–65
Laclaustra M, Stranges S, Navas-Acien A, Ordovas JM, Guallar E (2010) Serum selenium and plasma lipids in US adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004. Atherosclerosis 210(2):643–648
Zhou BF (2002) Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults-study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Biomed Environ Sci 15(1):83–96
Yuan LX, Zhang R, Ma XZ, Yang L, Zheng Q, Chen D, Li M, Fan T, Liu YX, Pan LP, Yin XB (2018) Selenium accumulation, antioxidant enzyme levels, and amino acids composition in Chinese mitten crab (Eriocheir sinensis) fed selenium-biofortified corn. Nutrients 10:318
Zhang QQ, Li WX, Wang J, Hu BY, Yun H, Guo RM, Wang L (2019) Selenium levels in community dwellers with type 2 diabetes mellitus. Biol Trace Elem Res 191(2):354–362
Fairweather-Tait SJ, Bao YP, Broadley MR, Collings R, Ford D, Hesketh JE, Hurst R (2011) Selenium in human health and disease. Antioxid Redox Sign 14(7):1337–1383
Huang JQ, Zhou JC, Wu YY, Ren FZ, Lei XG (2018) Role of glutathione peroxidase 1 in glucose and lipid metabolism-related diseases. Free Radic Biol Med 127:108–115
Burk RF (2002) Selenium, an antioxidant nutrient. Nutr Clin Care 5(2):75–79
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We express our sincere thanks to all participants in our study.
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Conceived and designed the experiments: Linxi Yuan and Liqiang Qin. Ethical application: Liqiang Qin and Linxi Yuan. Performed the experiments: Minming Zhang and Linxi Yuan. Participant recruitment: Feng Han and Linxi Yuan. Analyzed the data: Zheng Feei Ma and Linxi Yuan. Contributed reagents/materials/analysis tools: Xuebin Yin. Wrote the paper: Zheng Feei Ma and Linxi Yuan.
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All procedures performed in the study involving human participants were in accordance with the ethical standards of Ethics Committee of the Soochow University approved the study protocol (ref. no. ECSU-20160005), and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Yuan, L., Ma, Z.F., Zhang, M. et al. Hair Se Is a Sensitive Biomarker to Monitor the Effects of Se Supplementation in Elderly. Biol Trace Elem Res 200, 488–496 (2022). https://doi.org/10.1007/s12011-021-02674-6
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DOI: https://doi.org/10.1007/s12011-021-02674-6