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Ginseng Panaxoside Rb1 Reduces Body Weight in Diet-Induced Obese Mice

  • Translational Biomedical Research
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Abstract

Crude extracts from ginseng demonstrated anti-obesity properties. Ginsenoside Rb1 is the main component of ginseng, however, there are only few studies examining its effects in obesity. In the present study, we evaluated its potential anti-obesity effects in the murine model of diet-induced obesity. Seventy male C57BL/6 mice were randomly divided to consume for 12 weeks either chow diet (N = 8) or high-fat (HF) diet (N = 62). The latter mice were then divided into four groups: diet-induced obesity group (DIO; N = 10), obesity-resistant group (OR; N = 10), HF group (N = 5), and the group whose diet was changed from HF to normal diet (DC; N = 5). Intraperitoneal injections of Rb-1 were administered daily to mice in the DIO and OR groups for 3 weeks. Body weight and energy intake were monitored, and fasting blood glucose, lipids, neuropeptide Y, Y2 receptor, and peptide YY were quantified. Compared with HF group, weight gain and food intake of DIO mice with Rb-1 injection was significantly decreased (p < 0.05). Further, levels of blood glucose and some lipids were also decreased in DIO-Rb1 group compared with HF group. Furthermore, Rb1 was also found to modulate serum levels of PYY and NPY, and mRNA expression of NPY, Y2 receptor and PYY in tissue samples of DIO mice. Taken together, ginsenoside Rb1 may be useful in the treatment of obesity via modifying the serum content and mRNA expression of NPY, Y2 receptor and PYY.

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Acknowledgments

We thank Prof. Zhang Luoman for statistical analysis of research data.

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Authors and Affiliations

  1. Department of General Surgery, Chengdu Military General Hospital, 270 Rongdu Road, Chengdu, 610083, China

    Ning Lin

  2. Department of Clinical Nutrition, Changhai Hospital, The First Affiliated Hospital of The Second Military Medical University, 168 Changhai Road, Shanghai, 200433, China

    Dong-Lian Cai & Di Jin

  3. Department of Clinical Nutrition, Chengdu Military General Hospital, 270 Rongdu Road, Chengdu, 610083, China

    Ning Lin, Yi Chen & Jiao-Jiao Shi

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Correspondence to Ning Lin.

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Lin, N., Cai, DL., Jin, D. et al. Ginseng Panaxoside Rb1 Reduces Body Weight in Diet-Induced Obese Mice. Cell Biochem Biophys 68, 189–194 (2014). https://doi.org/10.1007/s12013-013-9688-3

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