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Claudins and Cancer Stem Cells

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Abstract

It is now believed that most epithelial tumors are maintained by a subpopulation of cells called cancer stem cells (CSCs) or tumor initiating cells (TICs) with stem cell-like properties, including self-renewal and multilineage differentiation capacity. Recently new insights into this population have emerged in certain epithelial tumor types, including their Claudinlow phenotype and its importance to the epithelial-mesenchymal transition (EMT) process. Taken together, CSCs, EMT and Claudins appear to constitute an axis-of-evil in cancer, for which better understanding may lead to new therapeutic platforms.

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References

  1. Sloma, I., Jiang, X., Eaves, A. C., & Eaves, C. J. (2010). Leukemia, 24, 1823–1833.

    Article  PubMed  CAS  Google Scholar 

  2. Maund, S. L. & Cramer, S. D. (2010). Stem Cell Rev.

  3. Lathia, J. D., Venere, M., Rao, M. S., & Rich, J. N. (2010). Stem Cell Rev.

  4. Regenbrecht, C. R., Lehrach, H., & Adjaye, J. (2008). Stem Cell Reviews, 4, 319–328.

    Article  PubMed  CAS  Google Scholar 

  5. Cobaleda, C., Cruz, J. J., Gonzalez-Sarmiento, R., Sanchez-Garcia, I., & Perez-Losada, J. (2008). Stem Cell Reviews, 4, 67–79.

    Article  PubMed  Google Scholar 

  6. McDermott, S. P., & Wicha, M. S. (2010). Mol Oncol, 4, 404–419.

    Article  PubMed  CAS  Google Scholar 

  7. Iwase, H., Kurebayashi, J., Tsuda, H., Ohta, T., Kurosumi, M., Miyamoto, K., et al. (2010). Breast Cancer, 17, 118–124.

    Article  PubMed  Google Scholar 

  8. Yamamoto, Y., Ibusuki, M., Nakano, M., Kawasoe, T., Hiki, R., & Iwase, H. (2009). Breast Cancer, 16, 260–267.

    Article  PubMed  Google Scholar 

  9. Carotenuto, P., Roma, C., Rachiglio, A. M., Botti, G., D’Alessio, A., & Normanno, N. (2010). Critical Reviews in Eukaryotic Gene Expression, 20, 17–34.

    PubMed  CAS  Google Scholar 

  10. Perou, C. M. (2011). The Oncologist, 16(Suppl 1), 61–70.

    Article  PubMed  Google Scholar 

  11. Furuse, M., Sasaki, H., Fujimoto, K., & Tsukita, S. (1998). The Journal of Cell Biology, 143, 391–401.

    Article  PubMed  CAS  Google Scholar 

  12. Turksen, K., & Troy, T. C. (2001). Developmental Dynamics, 222, 292–300.

    Article  PubMed  CAS  Google Scholar 

  13. Mineta, K., Yamamoto, Y., Yamazaki, Y., Tanaka, H., Tada, Y., Saito, K., et al. (2011). FEBS Letters, 585, 606–612.

    Article  PubMed  CAS  Google Scholar 

  14. Turksen, K., & Troy, T. C. (2004). Journal of Cell Science, 117, 2435–2447.

    Article  PubMed  CAS  Google Scholar 

  15. Turksen, K., & Troy, T. C. (2002). Development, 129, 1775–1784.

    PubMed  CAS  Google Scholar 

  16. Krause, G., Winkler, L., Mueller, S. L., Haseloff, R. F., Piontek, J., & Blasig, I. E. (2008). Biochimica et Biophysica Acta, 1778, 631–645.

    Article  PubMed  CAS  Google Scholar 

  17. Morin, P. J. (2005). Cancer Research, 65, 9603–9606.

    Article  PubMed  CAS  Google Scholar 

  18. Lanigan, F., McKiernan, E., Brennan, D. J., Hegarty, S., Millikan, R. C., McBryan, J., et al. (2009). International Journal of Cancer, 124, 2088–2097.

    Article  CAS  Google Scholar 

  19. Hewitt, K. J., Agarwal, R., & Morin, P. J. (2006). BMC Cancer, 6, 186.

    Article  PubMed  Google Scholar 

  20. Blackman, B., Russell, T., Nordeen, S. K., Medina, D., & Neville, M. C. (2005). Breast Cancer Research, 7, R248–R255.

    Article  PubMed  CAS  Google Scholar 

  21. Taube, J. H., Herschkowitz, J. I., Komurov, K., Zhou, A. Y., Gupta, S., Yang, J., et al. (2010). Proceedings of the National Academy of Sciences of the United States of America, 107, 15449–15454.

    Article  PubMed  CAS  Google Scholar 

  22. Prat, A., Parker, J. S., Karginova, O., Fan, C., Livasy, C., Herschkowitz, J. I., et al. (2010). Breast Cancer Research, 12, R68.

    Article  PubMed  Google Scholar 

  23. Hennessy, B. T., Gonzalez-Angulo, A. M., Stemke-Hale, K., Gilcrease, M. Z., Krishnamurthy, S., Lee, J. S., et al. (2009). Cancer Research, 69, 4116–4124.

    Article  PubMed  CAS  Google Scholar 

  24. Moreno-Bueno, G., Portillo, F., & Cano, A. (2008). Oncogene, 27, 6958–6969.

    Article  PubMed  CAS  Google Scholar 

  25. Creighton, C. J., Chang, J. C., & Rosen, J. M. (2010). Journal of Mammary Gland Biology and Neoplasia, 15, 253–260.

    Article  PubMed  Google Scholar 

  26. Martinez-Estrada, O. M., Culleres, A., Soriano, F. X., Peinado, H., Bolos, V., Martinez, F. O., et al. (2006). The Biochemical Journal, 394, 449–457.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgements

We are grateful to Dr. Jane Aubin for critical reading of this commentary and providing continuous intellectual support for our work. Our work on Claudins has been supported by CIHR.

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Authors and Affiliations

  1. Regenerative Medicine Program, Sprott Centre for Stem Cell Research at the Ottawa Hospital Research Institute, 501 Smyth Road-CCW5226, Ottawa, ON, K1Y 8L6, Canada

    Kursad Turksen

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  1. Kursad Turksen
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Correspondence to Kursad Turksen.

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Turksen, K. Claudins and Cancer Stem Cells. Stem Cell Rev and Rep 7, 797–798 (2011). https://doi.org/10.1007/s12015-011-9267-1

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  • DOI: https://doi.org/10.1007/s12015-011-9267-1

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