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Polymorphism of the renalase gene in gestational diabetes mellitus

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Abstract

Renalase is considered as a novel candidate gene for type 2 diabetes. In this study, we aimed to investigate the relationship of serum renalase and two single nucleotide polymorphisms with gestational diabetes mellitus. One hundred and ninety-eight normotensive pregnant females (n = 99 gestational diabetes mellitus; n = 99 euglycemic pregnant controls) were classified according to the International Association of the Diabetes and Pregnancy Study criteria. Fasting and 2-h post glucose load blood levels and anthropometric assessment was performed. Serum renalase was measured using enzyme-linked immunosorbent assay, whereas DNA samples were genotyped for renalase single nucleotide polymorphisms rs2576178 and rs10887800 using Polymerase chain reaction-Restriction fragment length polymorphism method. In an age-matched case control study, no difference was observed in the serum levels of renalase (p > 0.05). The variant rs10887800 showed an association with gestational diabetes mellitus and remained significant after multiple adjustments (p < 0.05), whereas rs2576178 showed weak association (p = 0.030) that was lost after multiple adjustments (p = 0.09). We inferred a modest association of the rs10887800 polymorphism with gestational diabetes. Although gestational diabetes mellitus is self-reversible, yet presence of this minor G allele might predispose to metabolic syndrome phenotypes in near the future.

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Funding source

Department of Biological and Biomedical Sciences, Research Module Fund.

Author contributions

SSF conceived and designed the study. HZM, SM, NR, MSA, AR, TS carried out the literature search, data collection, experimental analysis. SSF, FA, ZJ, and HZ were involved in manuscript writing. The final manuscript was approved by all authors for publication.

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    Authors and Affiliations

    1. Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan

      Syeda Sadia Fatima, Zehra Jamil & Faiza Alam

    2. Medical College, Aga Khan University, Karachi, Pakistan

      Hajira Zafar Malik, Sarosh Irfan Madhani, Muhammad Saad Ahmad, Tayyab Shabbir, Muhammed Noman Rehmani & Amna Rabbani

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    1. Syeda Sadia Fatima
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    Correspondence to Syeda Sadia Fatima.

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    Zehra Jamil and Faiza Alam have contributed equally to this work.

    Hajira Zafar Malik, Sarosh Madhani, Noman Rehmani, Muhammad Saad Ahmad, Amna Rabbani, and Tayyab Shabbir have contributed equally to this work.

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    Fatima, S.S., Jamil, Z., Alam, F. et al. Polymorphism of the renalase gene in gestational diabetes mellitus. Endocrine 55, 124–129 (2017). https://doi.org/10.1007/s12020-016-1058-7

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