Abstract
Introduction
Gastrointestinal system (GIS) is the most common site of involvement of all primary extranodal lymphomas. Gastric lymphoma constitutes 3–6% of all primary stomach malignancies. Stomach is also the commonest site of involvement of gastrointestinal stromal tumors (GIST). We would like to report these rare synchronous tumors in the same patient.
Case
A 68-year-old male was admitted to the internal medicine clinics with the complaints of abdominal distension. Physical examination was normal. On abdominal computed tomography a 12 × 14 × 22 cm sized giant tumoral mass was detected in left hypochondrium. A total gastrectomy was performed. Two distinct neoplasms were detected; one of which was located in the posterior wall of the stomach with the size of 24 × 16 × 13 cm, and the other one was localized in the fundus of the stomach and its size was 6 × 5 × 2 cm. Pathological evaluation revealed the diagnosis of GIST at the posterior wall and low-grade malignant lymphoma from the mass localized in the fundus of the stomach.
Discussion
Two primary tumors are not seen so often together in the stomach. Adenocarcinoma and associated tumors including gastric lymphoma (especially MALT lymphoma), carcinoid, leiomyosarcoma and rhabdomyosarcoma constitute most of the reported series. Rarely adenocarcinoma and associated GIST cases were reported. It is important to report concurrent gastric lymphoma and GIST case since it is extremely rare in the English literature.
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References
Kafes A, Hughes L, Hollinshead J, Katelaris P. Synchronous primary adenocarcinoma, mucosa-associated lymphoid tissue lymphoma and a stromal tumor in a helicobacter pylori-infected stomach. J Gastroenterol Hepatol 2002;17(9):1033–6.
Salar A, et al. Double diagnosis in cancer patients and cutaneous reaction related to gemcitabine: CASE 1. Synchronous mucosa associated lymphoid tissue lymphoma and gastrointestinal stromal tumors of the stomach. J Clin Oncol 2005;23(28):7221–3.
Kamimura H, et al. Gastrointestinal stromal tumor of the stomach: report of a case. Hepatogastroenterology 2005;52(64):1297–300.
Liu SW, Chen GH, Hsieh PP. Collision tumor of the stomach: a case report of mixed gastrointestinal stromal tumor and adenocarcinoma. J Clin Gastroenterol 2002;35(4):332–334.
Bircan S, et al. Synchronous primary adenocarcinoma and gastrointestinal stromal tumor in the stomach: a report of two cases. Turk J Gastroenterol 2004;15(3):187–91.
Nakamura S, et al. Synchronuos and metachronous primary gastric lymphoma and adenocarcinoma: a clinicopathological study of 12 patients. Cancer 1997;79(6):1077–85.
Wotherspoon AC, Isaacson PG. Synchronous adenocarcinoma and low grade B-cell lymphoma of mucosa associated lymphoid tissue (MALT) of the stomach. Histopathology 1995;27(4):325–31.
Miehlke S, Morgner A, Ehninger G. Gastric MALT lymphoma and gastrointestinal stromal tumors (GIST). Schweiz Rundsch Med Prax 2004;93(51–52):2143–50 (abstract).
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Pamukçuoğlu, M., Budakoğlu, B., Han, Ö. et al. An extraordinary case in whom gastrointestinal stromal tumor and low-grade malignant lymphoma are seen together in the stomach. Med Oncol 24, 351–353 (2007). https://doi.org/10.1007/s12032-007-0001-4
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DOI: https://doi.org/10.1007/s12032-007-0001-4