Skip to main content

Advertisement

SpringerLink
Log in

Quality of life one year after chemoradiotherapy for localized primary gastric diffuse large B-cell lymphoma

  • Original Paper
  • Published:
Medical Oncology Aims and scope Submit manuscript

Abstract

We assessed the quality of life (QOL) at least one year after sequential chemoradiotherapy for the treatment of localized gastric diffuse large B-cell lymphoma (DLBCL). We used the EORTC Quality of Life Questionnaire for Stomach Cancer (EORTC QLQ-STO22). Among the 45 patients available at the one-year follow-up after radiation therapy, 40 patients completed the EORTC QLQ-STO22 questionnaire. Their median age was 54.5 (range, 20–70 years). Social functioning was most adversely affected among the respondents with a score of 59, whereas other functions and the global scales were preserved above a score of 70 by linearly transformed values. Fatigue, the financial impact and specific emotional problems such as “thinking about their illness” (STO-ANX) and “worry about weight loss or future health” (STO-BI) were persistently bothersome for some patients. Other stomach-related symptoms such as dysphagia, pain, or reflux were negligible at 1 year after treatment. Therefore, this organ-preserving combined approach was effective for the maintenance of the QOL and minimization of stomach abnormalities in patients with gastric lymphoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Gurney KA, Cartwright RA, Gilman EA. Descriptive epidemiology of gastrointestinal non-Hodgkin’s lymphoma in a population-based registry. Br J Cancer. 1999;79:1929–34.

    Article  PubMed  CAS  Google Scholar 

  2. Ko YH, et al. REAL classification of malignant lymphomas in the Republic of Korea: incidence of recently recognized entities and changes in clinicopathologic features. Hematolymphoreticular Study Group of the Korean Society of Pathologists. Revised European-American lymphoma. Cancer. 1998;83:806–12.

    Article  PubMed  CAS  Google Scholar 

  3. Amer MH, El-Akkad S. Gastrointestinal lymphoma in adults: clinical features and management of 300 cases. Gastroenterology. 1994;106:846–58.

    PubMed  CAS  Google Scholar 

  4. Koch P, et al. Primary gastrointestinal non-Hodgkin’s lymphoma: I. Anatomic and histologic distribution, clinical features, and survival data of 371 patients registered in the German Multicenter Study GIT NHL 01/92. J Clin Oncol. 2001;19:3861–73.

    PubMed  CAS  Google Scholar 

  5. Binn M, et al. Surgical resection plus chemotherapy versus chemotherapy alone: comparison of two strategies to treat diffuse large B-cell gastric lymphoma. Ann Oncol. 2003;14:1751–7.

    Article  PubMed  CAS  Google Scholar 

  6. Liu HT, et al. Chemotherapy alone versus surgery followed by chemotherapy for stage I/IIE large-cell lymphoma of the stomach. Am J Hematol. 2000;64:175–9.

    Article  PubMed  CAS  Google Scholar 

  7. Raderer M, et al. Chemotherapy for the treatment of patients with primary high grade gastric B-cell lymphoma of modified Ann Arbor Stages IE and IIE. Cancer. 2000;88:1979–85.

    Article  PubMed  CAS  Google Scholar 

  8. Crump M, Gospodarowicz M, Shepherd FA. Lymphoma of the gastrointestinal tract. Semin Oncol. 1999;26:324–37.

    PubMed  CAS  Google Scholar 

  9. Blazeby JM, et al. Clinical and psychometric validation of a questionnaire module, the EORTC QLQ-STO 22, to assess quality of life in patients with gastric cancer. Eur J Cancer. 2004;40:2260–8.

    Article  PubMed  CAS  Google Scholar 

  10. Park YH, et al. CHOP followed by involved field radiotherapy for localized primary gastric diffuse large B-cell lymphoma: Results of a multi center phase II study and quality of life evaluation. Leuk Lymphoma. 2006;47:1253–9.

    Article  PubMed  CAS  Google Scholar 

  11. Vickery CW, Blazeby JM, Conroy T, Johnson CD, Alderson D. Development of an EORTC module to improve quality of life assessment in patients with gastric cancer. Br J Surg. 2000;87:362–73.

    Article  Google Scholar 

  12. Fayers PM, et al. (ed). EORTC QLQ-C30 scoring manual, 3rd edn. Brussels: EORTC Quality of Life Group; 2001, p. 6–14. http://www.eortc.be/home/qol/manuals.htm. Accessed March 2008.

  13. The International Non-Hodgkin’s Lymphoma Prognostic Factors Project. A predictive model for aggressive non-Hodgkin’s lymphoma. N Engl J Med. 1993;329:987–94.

    Google Scholar 

  14. Homepage of EORTC Qulaity of Life Group. http://groups.eortc.be/qol/questionnaires_qlqc30.htm. Accessed March 2008.

Download references

Acknowledgment

We acknowledge the EORTC to permit using the EORTC-STO22 module to conduct QOL analysis.

Author information

Authors and Affiliations

  1. Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

    Won Seog Kim, Yeon Hee Park, Kihyun Kim, Keon Woo Park, Do Hyoung Im, Jung Hun Kang, Jeeyun Lee & Keunchil Park

  2. Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea

    Se-Hoon Lee

  3. Department of Medicine, Institute of Radiological & Medical Sciences, Seoul, Korea

    Baek-Yeol Ryoo & Sung Hyun Yang

  4. Department of Pathology, Institute of Radiological & Medical Sciences, Seoul, Korea

    Seung-Sook Lee

  5. Department of Radiation Oncology, Institute of Radiological & Medical Sciences, Seoul, Korea

    Mi Sook Kim

  6. Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

    Young H. Ko

  7. Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

    Yong Chan Ahn & Do Hoon Lim

  8. Department of Internal Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam-si, Gyeongi-do, 463-707, Korea

    Soo-Mee Bang

Authors
  1. Won Seog Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yeon Hee Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Se-Hoon Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Baek-Yeol Ryoo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sung Hyun Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Seung-Sook Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Mi Sook Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Kihyun Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Keon Woo Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Do Hyoung Im
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Jung Hun Kang
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Jeeyun Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Young H. Ko
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Yong Chan Ahn
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Do Hoon Lim
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Keunchil Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. Soo-Mee Bang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Soo-Mee Bang.

Additional information

Won Seog Kim and Yeon Hee Park have contributed equally to this work.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kim, W.S., Park, Y.H., Lee, SH. et al. Quality of life one year after chemoradiotherapy for localized primary gastric diffuse large B-cell lymphoma. Med Oncol 25, 447–450 (2008). https://doi.org/10.1007/s12032-008-9065-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12032-008-9065-z

Keywords

Search

Navigation