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Genetic variants of MnSOD and GPX1 and susceptibility to bladder cancer in a Turkish population

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Abstract

This study was conducted to investigate the association of genetic polymorphisms in the MnSOD and GPX1 genes with the risk and invasiveness of bladder cancer in a Turkish population. This prospectively designed study enrolled 157 patients with bladder cancer (mean age 63.2 ± 10.86 years) and 224 healthy controls (mean age 61.7 ± 8.39 years). Genotyping of the MnSOD Ala-9Val and GPX1 Pro198Leu polymorphisms was carried out by PCR–RFLP. No significant difference was found in MnSOD genotype distributions between the controls and the bladder cancer patients. However, the Leu/Leu genotype of GPX1 was associated with a significantly higher risk of bladder cancer than the Pro/Pro genotype. When stratified according to tumor stage, the Leu/Leu genotype of GPX1 was more frequently observed in bladder cancer patients with high-stage tumors than those with low-stage tumors. Additionally, patients carrying both Ala/Ala of MnSOD and Leu/Leu of GPX1 had the highest risk of developing bladder cancer. In conclusion, the present study indicates that the GPX1 Pro198Leu polymorphism may be associated with the risk and development of invasive bladder cancer. In addition, the combination of the MnSOD Ala/Ala and GPX1 Leu/Leu genotypes may have a synergistic effect on disease risk.

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Acknowledgments

This work was supported by the Research Fund of Istanbul University, project number: 11658.

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Authors and Affiliations

  1. Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093, Istanbul, Turkey

    Canan Kucukgergin & Sule Seckin

  2. Department of Urology, Istanbul Faculty of Medicine, Istanbul University, 34093, Istanbul, Turkey

    Oner Sanli & Tzevat Tefik

  3. Department of Urology, Istanbul Teaching and Research Hospital, 34098, Istanbul, Turkey

    Akın S. Amasyalı

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  1. Canan Kucukgergin
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  2. Oner Sanli
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  3. Akın S. Amasyalı
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  4. Tzevat Tefik
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  5. Sule Seckin
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Correspondence to Sule Seckin.

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Kucukgergin, C., Sanli, O., Amasyalı, A.S. et al. Genetic variants of MnSOD and GPX1 and susceptibility to bladder cancer in a Turkish population. Med Oncol 29, 1928–1934 (2012). https://doi.org/10.1007/s12032-011-0057-z

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  • DOI: https://doi.org/10.1007/s12032-011-0057-z

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