Abstract
Laparoscopic surgery has been shown to offer more advantages than open surgery for the treatment of gastric cancer. However, the perioperative immune responses after laparoscopic surgery remain largely unexplored. Here, we analyzed the immunity of gastric cancer patients treated by laparoscopy-assisted gastrectomy (LAG) or open gastrectomy (OG) with D2 dissection. Seventy patients were randomized into LAG and OG groups. The operative details and postoperative outcomes of the two groups were compared. The immune factors were measured preoperatively as well as on the first, third, and seventh postoperative days (POD). Our results indicate that there was no significant difference between two groups in clinical characteristics. The profiles of white blood cells, neutrophils, lymphocytes, as well as the lymphocyte subpopulations, including T lymphocytes, B lymphocytes, CD4+ T cells, and CD8+ T cells were similar in the LAG and the OG groups. Only the natural killer cell counts were significantly higher in LAG-treated patients than in OG-treated ones on POD7. Moreover, no statistical differences were found between the two groups with respect to the levels of perioperative cytokines, including IFN-γ, IL-4, IL-6, and TNF-α. However, compared with the OG group, most of the immune factors in the LAG group had trends to return to preoperative levels on POD7. Our study demonstrates that the immune function of LAG-treated patients showed patterns similar to that of OG-treated patients, although larger prospective multicenter trials are needed to further evaluate the immunological status of LAG.
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Acknowledgments
This study was funded by the National Natural Science Foundation of China (Nos. 81272766, 81450028), the National High Technology Research and Development Program of China (863 Program, No. 2014AA020603), Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (No. XM201309), Peking University (PKU) 985 Special Funding for Collaborative Research with PKU Hospitals (To Xiangqian Su and Fan Bai), Seeding Grant for Medicine and Life Sciences of Peking University (2014-MB-04), Science Foundation of Peking University Cancer Hospital & Institute (No. 2014-14).
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The studies have been approved by the Research Ethics Committee of Peking University Cancer Hospital & Institute, Beijing, China (Approved No. 2012071710) and have been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the Research Ethics Committee of Peking University Cancer Hospital & Institute, Beijing, China (No. 2012071710) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
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Cui, M., Gong, C., Jiang, B. et al. Evaluation of immune responses of gastric cancer patients treated by laparoscopic and open gastrectomy. Med Oncol 32, 253 (2015). https://doi.org/10.1007/s12032-015-0699-3
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DOI: https://doi.org/10.1007/s12032-015-0699-3