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LincRNa-p21: function and mechanism in cancer

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Abstract

In view of the rapid development of gene chips and high-throughput sequencing technology, noncoding RNAs (ncRNas) form a high percentage of the mammalian genome. Two major subgroups of ncRNAs that have been identified are the long ncRNAs (lncRNas) and the microRNAs. A number of studies in the past few years have showed crucial functions for lncRNas in cancer. LincRNa-p21 as a p53-dependent transcriptional target gene and a potential diagnostic marker is involved in proliferation, cell cycle, metabolism and reprogramming. In addition, more researches revealed that lincRNa-p21 is associated with cancer progression and contributed to the treatment and prognosis of cancer. In this review, we briefly summarize the function and molecular mechanisms of lincRNa-p21 in cancer and its regulation for the genes expression .

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Acknowledgements

This study was funded by National Natural Science Foundation of China (Grant Number 81273116) and the Science Foundation of Guangdong Medical University (Grant Number M2013004).

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Author notes

  1. Shaoyun Chen and Hairong Liang have contributed equally to this study.

Authors and Affiliations

  1. Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, 523808, China

    Shaoyun Chen, Hairong Liang, Hui Yang, Kairu Zhou, Longmei Xu, Jiaxian Liu, Bei Lai, Li Song, Hao Luo & Huanwen Tang

  2. Huizhou Prevention and Treatment Centre for Occupational Disease, Huizhou, 516000, China

    Jianming Peng & Zhidong Liu

  3. Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China

    Yongmei Xiao & Wen Chen

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  1. Shaoyun Chen
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Correspondence to Huanwen Tang.

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Chen, S., Liang, H., Yang, H. et al. LincRNa-p21: function and mechanism in cancer. Med Oncol 34, 98 (2017). https://doi.org/10.1007/s12032-017-0959-5

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