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Biopolymers augment viral vectors based gene delivery

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Abstract

The success of viral vectors mediated gene therapy is still hampered by immunogenicity and insufficient transgene expression. Alternatively, non-viral vectors mediated gene delivery has the advantage of low immunogenicity despite showing low transgene expression. By carefully considering the advantages of each approach, hybrid vectors are currently being developed by modifying the viral vectors using non-viral biopolymers. This review provides an overview of the hybrid vectors currently being developed.

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Authors and Affiliations

  1. Department of Haematology, Christian Medical College, Vellore, 632004, Tamil Nadu, India

    Balaji Balakrishnan

  2. Department of Biotechnology, Thiruvalluvar University, Vellore, 632115, Tamil Nadu, India

    Ernest David

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  1. Balaji Balakrishnan
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  2. Ernest David
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Correspondence to Ernest David.

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Communicated by BJ Rao.

Corresponding editor: BJ Rao

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Balakrishnan, B., David, E. Biopolymers augment viral vectors based gene delivery. J Biosci 44, 84 (2019). https://doi.org/10.1007/s12038-019-9905-3

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