Abstract
Sarcoidosis (SA) is accompanied by malignancy more than can be explained by chance. Cancer can occur in patients with an established diagnosis of SA and SA can subsequently develop in a cancer patient. Malignancy can also be associated with the occurrence of sarcoid reactions (SR), which are typically restricted to the regional lymph nodes. Problems may also arise in distinguishing between tumour-related SRs and true systemic SA. Here we present a case with both SA and pancreatic cancer, and we discuss the result of distinguishing between SA and SRs in a patient with concurrent cancer.
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Brincker H, Wilbek E (1974) The incidence of malignant tumors in patients with sarcoidosis. Br J Cancer 29:247–251
Reich JM, Mullooly JP, Johnson RE (1995) Linkage analysis of malignancy-associated sarcoidosis. Chest 107:605–613
Romer FK, Hommelgaard P, Schou G (1998) Sarcoidosis and cancer revisited: a long-term followup study of 555 Danish sarcoidosis patients. Eur Respir J 12:906–912
Askling J, Grunewald J, Eklund A et al (1999) Increased risk for cancer following sarcoidosis. Am J Respir Crit Care Med 160:1668–1672
Mao JT, Fishbein MC (2000) Metastatic pancreatic cancer masquerading as pulmonary sarcoidosis. Am J Med 109:598–599
Saunders J (1976) Lymph node and hepatic granulomata associated with carcinoma. Br Med J 1:437–438
Brincker H (1986) Sarcoid reaction in malignant tumors. Cancer Treat Rev 13:147–156
Brincker H, Pedersen NT (1991) Immunohistologic separation of B-cell-positive granulomas from B-cell-negative granulomas in paraffin-embedded tissue with special reference to tumor-related sarcoid reactions. APMIS 99:282–290
Boros DL (1983) Experimental granulomatous disease. In: Fanberg BL (ed.) Sarcoidosis and other granulomatous diseases of the lung. Marcel Dekker, New York, pp 403–449
Brincker H (1992) Interpretation of granulomatous lesion in malignancy. Acta Oncol 6:85–89
Trump KL, Ettinger DS, Feldman JM et al (1981) Sarcoidosis and sarcoid-like lesions: their occurrence after cytotoxic and radiation therapy of testis cancer. Arch Intern Med 141:37–38
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Zambrana, F., Antúnez, A., García-Mata, J. et al. Sarcoidosis as a diagnostic pitfall of pancreatic cancer. Clin Transl Oncol 11, 396–398 (2009). https://doi.org/10.1007/s12094-009-0375-1
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DOI: https://doi.org/10.1007/s12094-009-0375-1