Abstract
Functional follicular ovarian cysts are frequently reported in girls with peripheral precocious puberty (PP). These cysts are usually self-limiting and resolve spontaneously. Several drugs like antiestrogens (tamoxifen) and new aromatase inhibitors are seldom used for treatment. Here we report a girl with peripheral PP who presented with unilateral enlargement of the ovary and a recurrent autonomous ovarian cyst. No skin pigmentation or bone anomaly was noted. The patient was successfully treated with anastrozole, a highly selective aromatase inhibitor. No adverse reaction was noted. Anastrozole is a safe and tolerable drug especially used to suppress estrogen action.
Similar content being viewed by others
References
Lee PA. Puberty and its disorders. In Lifshitz F ed. Pediatric Endocrinology. New York; Marcel Dekker, 2003; 216–217.
Dunkel L. Use of aromatase inhibitors to increase final height. Moll Cell Endocrinol 2006; 254–255: 207–216.
Feuillan PP, Jones J, Culler GB. Long term testolactone therapy for precocious puberty in girls with the McCune Albright syndrome. J Clin Endocrinol Metab 1993; 77: 47–51.
Rodriguez-Macias KA, Thibaud E, Houang M, Duflos C, Beldjord C, Rappaport R. Follow up of precocious pseudopuberty associated with isolated ovarian follicular cysts. Arch Dis Child 1999; 81: 53–56.
Kunz GJ, Mao CS, Gottschalk ME. Anastrozole use during precocious puberty in the McCune-Albright syndrome. In Proceedings of the Endocrine Society 85th Meeting. Philadelphia. The Endocrine Society Press, 2003; 293 (abstract PI-673).
Roth C, Freiberg C, Zappel H, Albers N. Effective aromatase inhibition by anastrozole in a patient with gonadotropinindependent precocious puberty in McCune-Albright syndrome. J Pediatr Endocrinol Metab 2002; 15(Suppl. 3): 945–948.
Eugster EA. Aromatase inhibitors in precocious puberty: rationale and experience to date. Treat Endocrinol 2004; 3: 141–151.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Engiz, O., Berberoglu, M., Siklar, Z. et al. Treatment of autonomous ovarian follicular cyst with long-term anastrozole therapy. Indian J Pediatr 76, 950–951 (2009). https://doi.org/10.1007/s12098-009-0190-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12098-009-0190-2