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Comparison of Myofibroblasts Expression in Oral Squamous Cell Carcinoma, Verrucous Carcinoma, High Risk Epithelial Dysplasia, Low Risk Epithelial Dysplasia and Normal Oral Mucosa

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Abstract

The aim was to evaluate and compare the presence of myofibroblasts in oral squamous cell carcinoma (OSCC), verrucous carcinoma (VC), high-risk epithelial dysplasia (HRED), low-risk epithelial dysplasia (LRED), and normal oral mucosa (NOM). The study consisted of 37 OSCC, 15 VC, 15 HRED, 15 LRED and 15 NOM. α-smooth muscle actin (α-SMA) antibody was used to identify myofibroblasts. The α-SMA expression was not observed in NOM and LRED. The α-SMA was expressed in 97.29% of OSCC, 86.66% of VC, 46.66 % of HRED. The α-SMA expression was significantly higher in OSCC than VC (p = 0.023) and HRED (p < 0.000). The α-SMA expression was significantly higher in VC than HRED (p = 0.043). Myofibroblastic expression, as highlighted by α-SMA, is undetectable in NOM and LRED but increases as the disease progresses from potentially malignant disorders, as HRED to VC to invasive OSCC. Thus, proliferation of myofibroblasts may be used as a stromal marker of oral premalignancy and malignancy.

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Acknowledgments

The authors extend their sincere thanks to Mr. Rupesh Maladhary, Lab Technician, Dept of Oral and Maxillofacial Pathology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Sawangi (M), Wardha, Maharashtra, India.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Pathology and Microbiology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Sawangi (Meghe), Wardha, 442001, Maharashtra, India

    Minal Chaudhary, Amol Ramchandra Gadbail, Gaurav Vidhale, Madhuri Gawande & Swati Patil

  2. Department of Orthodontia, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Sawangi (Meghe), Wardha, 442001, Maharashtra, India

    Mugdha P. Mankar (Gadbail)

  3. Department of Oral Diagnosis, Medicine and Radiology, MGV’s K.B.H. Dental College and Hospital, Nashik, Maharashtra, India

    Shailesh M. Gondivkar

  4. Plot No. 1, Shaktimata Nagar, Kharbi Road, Behind Hanuman Mandir, Nagpur, 440009, Maharashtra, India

    Amol Ramchandra Gadbail

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  1. Minal Chaudhary
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Correspondence to Amol Ramchandra Gadbail.

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Chaudhary, M., Gadbail, A.R., Vidhale, G. et al. Comparison of Myofibroblasts Expression in Oral Squamous Cell Carcinoma, Verrucous Carcinoma, High Risk Epithelial Dysplasia, Low Risk Epithelial Dysplasia and Normal Oral Mucosa. Head and Neck Pathol 6, 305–313 (2012). https://doi.org/10.1007/s12105-012-0335-x

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  • DOI: https://doi.org/10.1007/s12105-012-0335-x

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