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Quantitative evaluation of bone metastases from prostate cancer with simultaneous [18F] choline PET/MRI: combined SUV and ADC analysis

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Abstract

Objective

To quantitatively analyze bone metastases from prostate cancer and correlate the apparent diffusion coefficients (ADCs) and standardized uptake values (SUVs).

Methods

Fifty-five patients with biopsy-proven prostate cancer or suspected recurrent prostate cancer were examined with simultaneous [18F] choline Positron emission tomography (PET)/MRI at 3 T. In 11 patients, thirty-two PET-positive bone lesions could be identified that were located in the field-of-view of the Diffusion weighted imaging-sequence. Region-of-interest and volume-of-interest analyses were performed to measure the mean and minimal ADCs and to assess maximum and mean SUVs of every bone lesion. Correlations between maximum and mean SUVs and mean and minimal ADCs were calculated.

Results

The SUVmax of all lesions was 5.5 ± 3.1 (mean ± SD). The SUVmean was 1.8 ± 0.9. The mean ADC (ADCmean) of all lesions was 0.67 ± 0.13 × 10−3 mm2/s. The minimal ADC (ADCmin) of all lesions was 0.56 ± 0.14 × 10−3 mm2/s. There was a moderate but significant inverse correlation of SUVmax vs. ADCmean with a correlation coefficient of −0.4 (p = 0.02). There was also a significant inverse correlation of SUVmax vs. ADCmin with r = −0.41 (p = 0.02).

Conclusion

Our initial results demonstrate a moderate but significant inverse correlation between increased choline metabolism and ADC values of bone metastases from prostate cancer. Further research on a multimodality approach using simultaneous PET/MRI in bone metastasis of prostate cancer seems to be justified.

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Authors and Affiliations

  1. Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstraße 55, 45122, Essen, Germany

    Axel Wetter, Christine Lipponer, Felix Nensa, Thomas W. Schlosser & Thomas C. Lauenstein

  2. Department of Urology and Paediatric Urology, University Hospital Essen, Hufelandstraße 55, 45122, Essen, Germany

    Herbert Rübben

  3. Department of Nuclear Medicine, University Hospital Essen, Hufelandstraße 55, 45122, Essen, Germany

    Thorsten D. Pöppel & James Nagarajah

  4. Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, 40225, Düsseldorf, Germany

    Philipp Heusch

Authors
  1. Axel Wetter
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  2. Christine Lipponer
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  3. Felix Nensa
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  4. Philipp Heusch
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  5. Herbert Rübben
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  6. Thomas W. Schlosser
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  7. Thorsten D. Pöppel
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  8. Thomas C. Lauenstein
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  9. James Nagarajah
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Correspondence to Axel Wetter.

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Wetter, A., Lipponer, C., Nensa, F. et al. Quantitative evaluation of bone metastases from prostate cancer with simultaneous [18F] choline PET/MRI: combined SUV and ADC analysis. Ann Nucl Med 28, 405–410 (2014). https://doi.org/10.1007/s12149-014-0825-x

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  • DOI: https://doi.org/10.1007/s12149-014-0825-x

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