Abstract
Background
[18F]fluorodeoxyglucose positron emission tomography (PET) is a useful staging investigation for follicular lymphoma (FL). Recent studies have shown that positive post-treatment PET is also a strong predictor of inferior overall survival.
Purpose
To evaluate the predictive value of mid- and post-treatment PET in FL patients with respect to progression-free survival (PFS) and overall survival (OS).
Methods
We included 57 patients with indolent FL (grade 1, 2, and 3a) who received induction chemotherapy. Mid- and post-treatment PET results were correlated with PFS and OS retrospectively and analysed using Kaplan–Meier survival analysis and Cox regression.
Results
Post-treatment PET was predictive of OS (mean OS 95.2 vs. 45.0 months for PET-negative vs. PET-positive, p < 0.001) and showed a trend towards significance for PFS (mean PFS 74.4 vs. 38.2 months for PET− vs. PET+, p = 0.083). 3-year PFS for post-treatment PET− and PET+ patients were 72 and 30 %, respectively. 3-year OS were 96 and 60 %, respectively. Mid-treatment PET was not predictive of PFS (mean PFS 78.5 vs. 51.0 months for PET− vs. PET+, p = 0.35) nor OS (mean OS 89.9 vs. 76.6 months for PET− vs. PET+, p = 0.92).
Conclusion
Post-treatment PET is predictive of OS in indolent FL. It identifies patients who might benefit from more intensive follow-up, enrolment in clinical trials or second-line therapy. Mid-treatment PET scan results did not appear to predict long-term treatment outcomes.
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The authors declare that there are no conflict of interests.
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Lu, Z., Lin, M., Downe, P. et al. The prognostic value of mid- and post-treatment [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) in indolent follicular lymphoma. Ann Nucl Med 28, 805–811 (2014). https://doi.org/10.1007/s12149-014-0874-1
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DOI: https://doi.org/10.1007/s12149-014-0874-1