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Mesenchymal stromal cells for steroid-refractory acute graft-versus-host disease: a report of two cases

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Abstract

Severe graft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT). However, there have been only a few limited therapeutic options for the treatment of GVHD. Here we have reported two cases of the patients with acute steroid-refractory GVHD who underwent allogeneic HSCT. These patients received infusions of third-party clonal mesenchymal stem cells (cMSCs), which were isolated by a subfractionation culturing method (SCM) developed recently by our group, and showed marked improvement of the disease. MSCs represent a new potential therapeutic option in the treatment of steroid-refractory acute GVHD. They showed safety and improved clinical findings of the acute GVHD patients. However, further investigations are needed to understand the accurate mechanisms of MSCs and larger well-designed human clinical trials are necessary to prove further the safety and efficacy of the cMSCs for the treatment of acute GVHD patients.

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References

  1. Bacigalupo A. Management of acute graft-versus-host disease. Br J Haematol. 2007;137:87–98.

    Article  CAS  PubMed  Google Scholar 

  2. Ball L, Bredius R, Lankester A, Schweizer J, van den Heuvel-Eibrink M, Escher H, et al. Third party mesenchymal stromal cell infusions fail to induce tissue repair despite successful control of severe grade IV acute graft-versus-host disease in a child with juvenile myelo-monocytic leukemia. Leukemia. 2008;22:1256–7.

    Article  CAS  PubMed  Google Scholar 

  3. Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8:315–7.

    Article  CAS  PubMed  Google Scholar 

  4. Le Blanc K, Rasmusson I, Sundberg B, Gotherstrom C, Hassan M, Uzunel M, et al. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet. 2004;363:1439–41.

    Article  PubMed  Google Scholar 

  5. Song SU, Kim CS, Yoon SP, Kim SK, Lee MH, Kang JS, et al. Variations of clonal marrow stem cell lines established from human bone marrow in surface epitopes, differentiation potential, gene expression, and cytokine secretion. Stem Cells Dev. 2008;17:451–61.

    Article  CAS  PubMed  Google Scholar 

  6. Couriel D, Caldera H, Champlin R, Komanduri K. Acute graft-versus-host disease: pathophysiology, clinical manifestations, and management. Cancer. 2004;101:1936–46.

    Article  PubMed  Google Scholar 

  7. Friedenstein AJ, Petrakova KV, Kurolesova AI, Frolova GP. Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation. 1968;6:230–47.

    Article  CAS  PubMed  Google Scholar 

  8. Friedenstein AJ, Chailakhjan RK, Lalykina KS. The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet. 1970;3:393–403.

    CAS  PubMed  Google Scholar 

  9. Le Blanc K, Frassoni F, Ball L, Locatelli F, Roelofs H, Lewis I, et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet. 2008;371:1579–86.

    Article  CAS  PubMed  Google Scholar 

  10. Lazarus HM, Koc ON, Devine SM, Curtin P, Maziarz RT, Holland HK, et al. Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biol Blood Marrow Transpl. 2005;11:389–98.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, Inha University Hospital, Inha University College of Medicine, Incheon, Korea

    Joo Han Lim, Moon Hee Lee, Hyeon Gyu Yi & Chul Soo Kim

  2. Clinical Research Center, Inha University Hospital, Inha University College of Medicine, 7-206, 3-Ga, Shinheuong-Dong, Jung-Gu, Incheon, 400-711, Korea

    Jun Hyung Kim & Sun U. Song

Authors
  1. Joo Han Lim
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  2. Moon Hee Lee
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  3. Hyeon Gyu Yi
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  4. Chul Soo Kim
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  5. Jun Hyung Kim
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  6. Sun U. Song
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Corresponding author

Correspondence to Sun U. Song.

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Lim, J.H., Lee, M.H., Yi, H.G. et al. Mesenchymal stromal cells for steroid-refractory acute graft-versus-host disease: a report of two cases. Int J Hematol 92, 204–207 (2010). https://doi.org/10.1007/s12185-010-0606-9

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  • DOI: https://doi.org/10.1007/s12185-010-0606-9

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