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Disappearance of double minute chromosomes with MYC amplification in relapsed acute myeloid leukemia after stem cell transplantation

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References

  1. Von Hoff DD, McGill JR, Forseth BJ, Davidson KK, Bradley TP, Van Devanter DR, et al. Elimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity. Proc Natl Acad Sci USA. 1992;89:8165–9.

    Article  Google Scholar 

  2. Yu L, Zhao Y, Quan C, Ji W, Zhu J, Huang Y, et al. Gemcitabine eliminates double minute chromosomes from human ovarian cancer cells. PLoS One. 2013;8:e71988.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  3. Raymond E, Faivre S, Weiss G, McGill J, Davidson K, Izbicka E, et al. Effects of hydroxyurea on extrachromosomal DNA in patients with advanced ovarian carcinomas. Clin Cancer Res. 2001;7:1171–80.

    CAS  PubMed  Google Scholar 

  4. Schoenlein PV, Barrett JT, Kulharya A, Dohn MR, Sanchez A, Hou DY, et al. Radiation therapy depletes extrachromosomally amplified drug resistance genes and oncogenes from tumor cells via micronuclear capture of episomes and double minute chromosomes. Int J Radiat Oncol Biol Phys. 2003;55:1051–65.

    Article  CAS  PubMed  Google Scholar 

  5. Yamamoto K, Okamura A, Sanada Y, Yakushijin K, Matsuoka H, Minami H. Micronuclei-associated MYC amplification in the form of double minute chromosomes in acute myeloid leukemia. Am J Hematol. 2013;88:717–8.

    Article  CAS  PubMed  Google Scholar 

  6. Chinen Y, Sakamoto N, Nagoshi H, Taki T, Maegawa S, Tatekawa S, et al. 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia. J Hematol Oncol. 2014;7:68.

    Article  PubMed Central  PubMed  Google Scholar 

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Correspondence to Katsuya Yamamoto.

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Yamamoto, K., Yakushijin, K., Kurata, K. et al. Disappearance of double minute chromosomes with MYC amplification in relapsed acute myeloid leukemia after stem cell transplantation. Int J Hematol 101, 423–425 (2015). https://doi.org/10.1007/s12185-015-1757-5

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  • DOI: https://doi.org/10.1007/s12185-015-1757-5

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