Skip to main content
SpringerLink
Log in

Correlation of Quantitated Intravascular Volume with Blood Pressure in Patients with Systemic Hypertension

  • Correspondence
  • Published:
Journal of Cardiovascular Translational Research Aims and scope Submit manuscript

Abstract

Volume management is an essential component of anti-hypertensive therapy. Different volume phenotypes have been proposed. We sought to study the total blood volume (TBV), plasma volume (PV), and red blood cell volume (RBV) in hypertensive patients. We included patients followed in an outpatient cardiology clinic from 1998 to 2003. Blood volume (BV) parameters were measured using radioisotope iodine-131-labeled albumin dilution technique. Values were expressed as percentage (%) deviation from ideal volumes. A total of 95 patients were included. The intravascular volume distribution as percent deviation from normal volume ranged from − 23 to + 28% for TBV, − 22 to + 36% for PV and − 29 to + 37% for RBV. There was no significant correlation between systolic BP and any of the BV parameters (TBV and SBP, r = − 0.03; PV and SBP, r = − 0.12; RBV and SBP, r = − 0.08). Patients with hypertension have a wide variation in BV parameters. BV does not correlate with SBP.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Weidmann, P., Hirsch, D., Beretta-Piccoli, C., Reubi, F. C., & Ziegler, W. H. (1977). Interrelations among blood pressure, blood volume, plasma renin activity and urinary catecholamines in benign essential hypertension. The American Journal of Medicine, 62, 209–218.

    Article  CAS  Google Scholar 

  2. Feldschuh, J., & Katz, S. (2007). The importance of correct norms in blood volume measurement. The American Journal of the Medical Sciences, 334, 41–46.

    Article  Google Scholar 

  3. Mayet, J., & Hughes, A. (2003). Cardiac and vascular pathophysiology in hypertension. Heart, 89, 1104–1109.

    Article  Google Scholar 

  4. Laragh, J. H., Sealey, J. E., Niarchos, A. P., & Pickering, T. G. (1982). The vasoconstriction-volume spectrum in normotension and in the pathogenesis of hypertension. Federation Proceedings, 41, 2415–2423.

    CAS  PubMed  Google Scholar 

  5. Feldschuh, J., & Enson, Y. (1977). Prediction of the normal blood volume. Relation of blood volume to body habitus. Circulation, 56, 605–612.

    Article  CAS  Google Scholar 

  6. Chrysant, S. G., Danisa, K., Kem, D. C., Dillard, B. L., Smith, W. J., & Frohlich, E. D. (1979). Racial differences in pressure, volume and renin interrelationships in essential hypertension. Hypertension (Dallas, Tex : 1979), 1, 136–141.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA

    Marat Fudim & Vanessa L. Blumer

  2. Duke Clinical Research Institute, Durham, NC, USA

    Marat Fudim & Renato D. Lopes

  3. CIC-Inserm 1433, Inserm U1116, Nancy University hospital, and FCRIN INI-CRCT, University of Lorraine, Nancy, France

    Patrick Rossignol

  4. Daxor, New York, NY, USA

    Michael Feldschuh

  5. Department of Medicine, Mayo Clinic, Rochester, MN, USA

    Wayne L. Miller

  6. Department of Medicine, Ohio State University, Columbus, OH, USA

    Paul A. Sobotka

Authors
  1. Marat Fudim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Vanessa L. Blumer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Renato D. Lopes
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Patrick Rossignol
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Michael Feldschuh
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Wayne L. Miller
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Paul A. Sobotka
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Marat Fudim.

Ethics declarations

Human and Animal Studies

No human or animal studies were carried out by the authors for this article.

Conflict of Interest

Marat Fudim is supported by an American Heart Association grant 17MCPRP33460225 and NIH T32 grant 5T32HL007101; he consults for Coridea, AxonTherapies, and Galvani. Renato D. Lopes research grants: Amgen, Bristol-Myers Squibb/Pfizer, GlaxoSmithKline, Medtronic PLC, Sanofi-Aventis; consulting/advisory board fees: Bristol-Myers Squibb/Pfizer, Bayer, Boehringer Ingelheim. Michael Feldschuh is an employee of Daxor. All other authors declare that they have no conflict of interest.

Clinical Relevance

Hypertension is one of the major health risk factors, and uncontrolled hypertension is highly prevalent. The physiology of hypertension is complex and knowledge of volume phenotypes might be relevant to clinical management.

Additional information

Associate Editor Ana Barac oversaw the review of this article

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fudim, M., Blumer, V.L., Lopes, R.D. et al. Correlation of Quantitated Intravascular Volume with Blood Pressure in Patients with Systemic Hypertension. J. of Cardiovasc. Trans. Res. 13, 528–530 (2020). https://doi.org/10.1007/s12265-019-09910-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12265-019-09910-4

Keywords

Search

Navigation