Abstract
The aim of this study is to delineate laboratory diagnostic strategies for subclinical hypothyroidism in patients who are clinically symptomatic but may have a normal thyroid profile. Tri — iodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH) and anti thyroid peroxidase antibodies (anti-TPO) were estimated on fasting blood samples from 99 patients using electrochemiluminescence methods on ELECSYS 1010 (Roche). 74% of study subjects had elevated anti-TPO levels.61% patients had subclinical hypothyroidism. 45 of the 61 subclinical hypothyroid patients had elevated anti-TPO levels (73%). This is an important finding suggesting an autoimmune etiology for subclinical thyroid dysfunction with a higher risk of developing overt hypothyroidism.
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Mohanty, S., Amruthlal, W., Reddy, G.C. et al. Diagnostic strategies for subclinical hypothyroidism. Indian J Clin Biochem 23, 279–282 (2008). https://doi.org/10.1007/s12291-008-0062-y
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DOI: https://doi.org/10.1007/s12291-008-0062-y