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Le lymphome primitif de la prostate: à propos d’un cas avec revue de la littérature

Primary lymphoma of the prostate: Report of a case and review of the literature

  • Cas Clinique
  • Published:
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Le lymphome primitif de la prostate est une affection maligne rare. Les patients présentent initialement des signes urinaires locaux et des signes généraux. Plusieurs traitements ont été utilisés comme la prostatectomie radicale, la radiothérapie ou des associations de chimiothérapie et de radiothérapie. Une revue de la littérature fait état du mauvais pronostic du lymphome de la prostate, le diagnostic se faisant souvent à un stade tardif. Nous rapportons le cas d’un patient âgé de 73 ans présentant une rétention aiguë d’urines dans un contexte de constipation opiniâtre avec amaigrissement sévère. Il était diabétique, aux antécédents de carcinome urothélial de stade pT1 et de grade G3, traité par résection transurétrale et BCG thérapie. L’examen clinique a révélé une prostate très augmentée de volume, ce qui a été confirmé par les examens d’imagerie. L’analyse anatomo-pathologique des biopsies réalisées par voie transrectale a mis en évidence un lymphome malin non Hodgkinien de type B primitif de la prostate. La prise en charge a consisté en une chimiothérapie. Malgré une régression considérable du volume tumoral à partir de la troisième semaine, le patient est décédé au lendemain de son 5ème cycle de chimiothérapie.

Abstract

Primary lymphoma of the prostate is a rare malignancy. Patients initially present with local and general symptoms. A variety of treatments have been used, including prostatectomy, radiotherapy, or a combination of chemotherapy and radiotherapy. Reports in the literature reflect the poor outcome of prostatic lymphoma due to the fact that it is usually diagnosed late. We report the case of a 73-year-old patient who presented with urinary retention associated with persistent constipation and considerable weight loss. He was diabetic and reported a history of transitional cell carcinoma stage pT1, grade G3, which had been treated with transurethral resection and BCG therapy. Physical examination revealed a considerably enlarged prostate which was confirmed by imaging studies. Histological analysis of the tissue obtained on transrectal biopsy revealed a primary malignant non-Hodgkin lymphoma, type B, of the prostate. The patient was treated with chemotherapy. Despite considerable reduction of the tumor size starting from the 3rd week, the patient died the day after his 5th course of chemotherapy.

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Authors and Affiliations

  1. Service d’Urologie, Hôpital d’Instruction des Armées du Val De Grâce, Paris, France

    Omar Ghoundale, E. Deligne, A. N’Diaye, F. R. Desfemmes & A. Houlgatte

  2. Service d’anatomie pathologique, Hôpital d’Instruction des Armées du Val De Grâce, Paris, France

    P. Camparo

  3. Service d’Urologie, HIA Val De Grâce, 74, Bd Port Royal, 75 230, Paris, France

    Omar Ghoundale

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  1. Omar Ghoundale
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  2. E. Deligne
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  3. P. Camparo
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  4. A. N’Diaye
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  5. F. R. Desfemmes
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  6. A. Houlgatte
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Correspondence to Omar Ghoundale.

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Ghoundale, O., Deligne, E., Camparo, P. et al. Le lymphome primitif de la prostate: à propos d’un cas avec revue de la littérature. Afr J Urol 15, 148–153 (2009). https://doi.org/10.1007/s12301-009-0024-5

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  • DOI: https://doi.org/10.1007/s12301-009-0024-5

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