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Primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma

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Abstract

Primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma is extremely rare, and the etiology of disease is not fully understood. We present herein the case of a primary hepatic MALT lymphoma with Helicobacter pylori and hepatitis C virus infection. A 71-year-old male was admitted to our institution to undergo a precise evaluation of a hepatic tumor incidentally detected during a computed tomography (CT) scan for chest examination. Dynamic CT showed faint enhancement during the arterial phase. The gadoxetate disodium-enhanced magnetic resonance imaging showed a hyper-intensity on the arterial phase and low intensity during the late and hepatocyte phases. Liver biopsy specimen showed small to intermediate size atypical lymphocytes with positive CD20 immunohistochemical staining. It was finally diagnosed as primary hepatic MALT lymphoma. FDG-PET/CT showed faintly increased uptake with a maximum standardized uptake value of 4.6, and did not show other pathological uptake. We present the rare case of primary hepatic MALT lymphoma and discussed the etiology of this disease.

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References

  1. Zucca E, Conconi A, Pedrinis E, Cortelazzo S, Motta T, Gospodarowicz MK, International Extranodal Lymphoma Study Group, et al. Nongastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. Blood. 2003;101:2489–95.

    Article  PubMed  CAS  Google Scholar 

  2. Iida T, Iwahashi M, Nakamura M, Nakamori M, Yokoyama S, Tani M, et al. Primary hepatic low-grade B-cell lymphoma of malt-type associated with Helicobacter pylori infection. Hepatogastroenterology. 2007;54:1898–901.

    PubMed  Google Scholar 

  3. Isaacson PG, Banks PM, Best PV, McLure SP, Muller-Hermelink HK, Wyatt JI. Primary low-grade hepatic B-cell lymphoma of mucosa-associated lymphoid tissue (MALT)-type. Am J Surg Pathol. 1995;19:571–5.

    Article  PubMed  CAS  Google Scholar 

  4. Prabhu RM, Medeiros LJ, Kumar D, Drachenberg CI, Papadimitriou JC, Appelman HD, et al. Primary hepatic low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) associated with primary biliary cirrhosis. Mod Pathol. 1998;11:404–10.

    PubMed  CAS  Google Scholar 

  5. Ye MQ, Suriawinata A, Black C, Min AD, Strauchen J, Thung SN. Primary hepatic marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type in a patient with primary biliary cirrhosis. Arch Pathol Lab Med. 2000;124:604–8.

    PubMed  CAS  Google Scholar 

  6. Ueda G, Oka K, Matsumoto T, Yatabe Y, Yamanaka K, Suyama M, et al. Primary hepatic marginal zone B-cell lymphoma with mantle cell lymphoma phenotype. Virchows Arch. 1996;428:311–4.

    Article  PubMed  CAS  Google Scholar 

  7. Nakayama S, Yokote T, Kobayashi K, Hirata Y, Akioka T, Miyoshi T, et al. Primary hepatic MALT lymphoma associated with primary biliary cirrhosis. Leuk Res. 2010;34:e17–20.

    Article  PubMed  CAS  Google Scholar 

  8. Freeman C, Berg JW, Cutler SJ. Occurrence and prognosis of extranodal lymphomas. Cancer. 1972;29:252–60.

    Article  PubMed  CAS  Google Scholar 

  9. Maes M, Depardieu C, Dargent JL, Hermans M, Verhaeghe JL, Delabie J, et al. Primary low-grade B-cell lymphoma of MALT-type occurring in the liver: a study of two cases. J Hepatol. 1997;27:922–7.

    Article  PubMed  CAS  Google Scholar 

  10. Mizuno S, Isaji S, Tabata M, Uemoto S, Imai H, Shiraki K. Hepatic mucosa-associated lymphoid tissue (MALT) lymphoma associated with hepatitis C. J Hepatol. 2002;37:872–3.

    Article  PubMed  Google Scholar 

  11. Ascoli V, Lo Coco F, Artini M, Levrero M, Martelli M, Negro F. Extranodal lymphomas associated with hepatitis C virus infection. Am J Clin Pathol. 1998;109:600–609.

    Google Scholar 

  12. Kirk CM, Lewin D, Lazarchick J. Primary hepatic B-cell lymphoma of mucosa-associated lymphoid tissue. Arch Pathol Lab Med. 1999;123:716–9.

    PubMed  CAS  Google Scholar 

  13. Chen F, Ike O, Wada H, Hitomi S. Pulmonary mucosa-associated lymphoid tissue lymphoma 8 years after resection of the same type of lymphoma of the liver. Jpn J Thorac Cardiovasc Surg. 2000;48:233–5.

    Article  PubMed  CAS  Google Scholar 

  14. Murakami J, Fukushima N, Ueno H, Saito T, Watanabe T, Tanosaki R, et al. Primary hepatic low-grade B-cell lymphoma of the mucosa-associated lymphoid tissue type: a case report and review of the literature. Int J Hematol. 2002;75:85–90.

    Article  PubMed  Google Scholar 

  15. Avenaud P, Marais A, Monteiro L, Le Bail B, Bioulac Sage P, Balabaud C, et al. Detection of Helicobacter species in the liver of patients with and without primary liver carcinoma. Cancer 2000;89:1431–9.

    Google Scholar 

  16. Fukuda K, Kuroki T, Tajima Y, Tsuneoka N, Kitajima T, Matsuzaki S, et al. Comparative analysis of Helicobacter DNAs and biliary pathology in patients with and without hepatobiliary cancer. Carcinogenesis. 2002;23:1927–31.

    Article  PubMed  CAS  Google Scholar 

  17. Bulajic M, Maisonneuve P, Schneider-Brachert W, Müller P, Reischl U, Stimec B, et al. Helicobacter pylori and the risk of benign and malignant biliary tract disease. Cancer. 2002;95:1946–53.

    Article  PubMed  Google Scholar 

  18. Tursi A, Brandimarte G, Torello M. Disappearance of gastric mucosa-associated lymphoid tissue in hepatitis C virus-positive patients after anti-hepatitis C virus therapy. J Clin Gastroenterol. 2004;38:360–3.

    Article  PubMed  Google Scholar 

  19. Doi H, Horiike N, Hiraoka A, Koizumi Y, Yamamoto Y, Hasebe A, et al. Primary hepatic marginal zone B cell lymphoma of mucosa-associated lymphoid tissue type: case report and review of the literature. Int J Hematol. 2008;88:418–23.

    Article  PubMed  Google Scholar 

  20. Raderer M, Jäger G, Brugger S, Püspök A, Fiebiger W, Drach J, et al. Rituximab for treatment of advanced extranodal marginal zone B cell lymphoma of the mucosa-associated lymphoid tissue lymphoma. Oncology. 2003;65:306–10.

    Article  PubMed  CAS  Google Scholar 

  21. Raderer M, Streubel B, Woehrer S, Puespoek A, Jaeger U, Formanek M, et al. High relapse rate in patients with MALT lymphoma warrants lifelong follow-up. Clin Cancer Res. 2005;11:3349–52.

    Article  PubMed  Google Scholar 

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Conflict of interest

No conflict of interest for all authors.

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Authors and Affiliations

  1. Department of Gastroenterology, Fuji Heavy Industries Health Insurance Society, Ota Memorial Hospital, Ota, Gunma, 373-8585, Japan

    Tetsuya Hamada

  2. Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan

    Satoru Kakizaki & Masatomo Mori

  3. Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, 371-8511, Japan

    Hiromi Koiso

  4. Department of Hematology, Gunma Prefectural Cancer Center, Ota, Gunma, 373-8500, Japan

    Hiroyuki Irisawa

  5. Department of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma, 371-8511, Japan

    Sumihito Nobusawa

Authors
  1. Tetsuya Hamada
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  2. Satoru Kakizaki
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  3. Hiromi Koiso
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  4. Hiroyuki Irisawa
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  5. Sumihito Nobusawa
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  6. Masatomo Mori
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Correspondence to Satoru Kakizaki.

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Hamada, T., Kakizaki, S., Koiso, H. et al. Primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma. Clin J Gastroenterol 6, 150–155 (2013). https://doi.org/10.1007/s12328-013-0362-5

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  • DOI: https://doi.org/10.1007/s12328-013-0362-5

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