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Sleep Quality in Ulcerative Colitis: Associations with Inflammation, Psychological Distress, and Quality of Life

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Abstract

Purpose

Treatment of ulcerative colitis (UC), given its chronicity and its associated disruptive and often distressing symptoms, is increasingly focusing on maximizing patient quality of life. Poorer quality of life has been found among patients with poor sleep quality, which is much more common in patients with UC than in the general population and may be associated with inflammation and psychological distress.

Method

Forty-seven patients with UC (n = 11 flaring) completed measures of sleep quality, depression, state anxiety, gastrointestinal-related anxiety, perceived stress, and quality of life. Measures of inflammation were also obtained.

Results

Patients endorsed high rates of poor sleep quality, which was highly correlated with depression and poorer inflammatory bowel disease-related quality of life, but was generally not related to other areas of psychological functioning or inflammation. Sleep quality was significantly independently associated with depression and female gender.

Conclusion

Poor sleep quality is prevalent in patients with UC and is strongly related to depression, suggesting that sleep and mood are important areas to assess in patients with UC in order to inform tailored treatment to improve quality of life.

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Funding

This work was supported by the National Center for Complementary and Integrative Health at the National Institutes of Health (grant number 5R01AT007143-05).

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Authors and Affiliations

  1. Rush University Medical Center, 1645 W Jackson, Suite 400, Chicago, IL, 60612, USA

    Megan M. Hood, Rebecca Wilson, Annika Gorenz, Sharon Jedel, Shohreh Raeisi, Stevan Hobfoll & Ali Keshavarzian

Authors
  1. Megan M. Hood
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  2. Rebecca Wilson
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  3. Annika Gorenz
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  4. Sharon Jedel
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  5. Shohreh Raeisi
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  7. Ali Keshavarzian
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Corresponding author

Correspondence to Megan M. Hood.

Ethics declarations

This study was approved by the Institutional Review Board and has been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments. Informed consent was obtained from all individuals included in the study.

Conflict of Interest

The authors declare that there is no conflict of interest.

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Hood, M.M., Wilson, R., Gorenz, A. et al. Sleep Quality in Ulcerative Colitis: Associations with Inflammation, Psychological Distress, and Quality of Life. Int.J. Behav. Med. 25, 517–525 (2018). https://doi.org/10.1007/s12529-018-9745-9

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  • DOI: https://doi.org/10.1007/s12529-018-9745-9

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