Skip to main content
Log in

Celiac disease suspected at endoscopy in patients with chronic liver disease

  • Short Report
  • Published:
Indian Journal of Gastroenterology Aims and scope Submit manuscript

Abstract

Endoscopic findings of celiac disease have high specificity and sensitivity. We evaluated records of 137 consecutive patients who had endotherapy for variceal hemorrhage, and who had features of celiac disease at endoscopy; patients who had such markers at endoscopy had undergone duodenal histology and serology. Thirty-one patients had changes of portal hypertensive vasculopathy in the duodenum, 8 had scalloping, and 6 had mosaic pattern; 3 patients also had decreased fold height or sparse folds in the descending duodenum. Six of these 8 patients had positive serology and histology suggestive of celiac disease. Endoscopic evaluation resulted in diagnosis of CD in 4.37% patients of chronic liver disease undergoing endotherapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Ciacci C, Cirillo M, Sollazzo R. Gender and clinical presentation in adult celiac disease. Scand J Gastroenterol. 1995;30:1077–81.

    Article  PubMed  CAS  Google Scholar 

  2. Rubio-Tapia A, Murray JA. The liver in celiac disease. Hepatology. 2007;46:1650–8.

    Article  PubMed  CAS  Google Scholar 

  3. Bardella MT, Franquelli M, Quatrini M, Molteni N, Bianchi P, Conte D. Prevalence of hypertransaminasemia in adult celiac patients and effect of gluten-free diet. Hepatology. 1995;22:833–6.

    PubMed  CAS  Google Scholar 

  4. Volta U, De Franceschi L, Lari F, Molinaro N, Zoli M, Bianchi F. Celiac disease hidden by cryptogenic hypertransaminasemia. Lancet. 1998;353:26–9.

    Article  Google Scholar 

  5. Bardella MT, Vecchi M, Contre D, et al. Chronic unexplained hypertransaminasemia may be caused by occult celiac disease. Hepatology. 1999;29:654–7.

    Article  PubMed  CAS  Google Scholar 

  6. Dickey W, McMillan S, Callender M. High prevalence of celiac sprue among patients with primary biliary cirrhosis. J Clin Gastroenterol. 1997;25:328–9.

    Article  PubMed  CAS  Google Scholar 

  7. Kingham JGC, Parker DR. The association between primary biliary cirrhosis and celiac disease: a study of relative prevalence. Gut. 1998;42:120–2.

    Article  PubMed  CAS  Google Scholar 

  8. Volta U, DeFranceschi L, Molinaro N, et al. Frequency and significance of anti-gliadin and anti-endomysial anti-bodies in autoimmune hepatitis. Dig Dis Sci. 1998;43:2190–5.

    Article  PubMed  CAS  Google Scholar 

  9. Hay JE, Wiesner RH, Shorter RG, La Russo NF, Baldus WP. Primary sclerosing cholangitis and celiac disease. A novel association. Ann Intern Med. 1988;109:713–7.

    PubMed  CAS  Google Scholar 

  10. Fracassetti O, Delvecchio G, Tambini R, Loernzi N, Gavazzeni G. Primary sclerosing cholangitis with celiac sprue: four cases. J Clin Gastroenterol. 1996;22:71–2.

    Article  PubMed  CAS  Google Scholar 

  11. Ludvigsson JF, Elfstrom P, Broome U, Ekbom A, Montgomery SM. Celiac disease and risk of liver disease; a general population-based study. Clin Gastroenterol Hepatol. 2007;5:63–9.

    Article  PubMed  Google Scholar 

  12. Dickey W. Diagnosis of celiac disease at open-access endoscopy. Scand J Gastroenterol. 1998;33:612–5.

    Article  PubMed  CAS  Google Scholar 

  13. McIntyre AS, Ng DPK, Smith JA, et al. The endoscopic appearance of duodenal folds is predictive of untreated adult celiac disease. Gastrointest Endosc. 1992;38:148–51.

    Article  PubMed  CAS  Google Scholar 

  14. Sood A, Midha V, Sood N, Avasthi G, Sehgal A. Prevalence of celiac disease among school children in Punjab, North India. J Gastroenterol Hepatol. 2006;21:1622–5.

    Article  PubMed  Google Scholar 

  15. Figueredo P, Almeida N, Lerlas C, et al. Effect of portal hypertension in the small bowel: an endoscopic approach. Dig Dis Sci. 2008;53:2144–50.

    Article  Google Scholar 

  16. Ravelli AM, Tobanelli P, Minelli L, Villanacci V, Cestari R. Endoscopic features of celiac disease in children. Gastrointest Endosc. 2001;54:736–42.

    Article  PubMed  CAS  Google Scholar 

  17. Oberhuber G, Granditsch G, Vogelsang H. The histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur J Gastroenterol Hepatol. 1999;11:1185–94.

    Article  PubMed  CAS  Google Scholar 

  18. Kochhar R, Masoodi I, Singhal M, et al. Celiac disease associated with Budd-Chiari syndrome: a case report with review of literature. Eur J Gastroenterol Hepatol. 2009;21:1092–4.

    Article  PubMed  Google Scholar 

  19. Lo W, Sano K, Lelswahe B, Diamond B, Green PHR. Changing presentation of adult celiac disease. Dig Dis Sci. 2003;48:395–8.

    Article  PubMed  Google Scholar 

  20. Olds G, McLoughlin R, O’Morian C, Sivak Jr MV. Celiac disease for the endoscopist. Gastrointest Endosc. 2002;57:407–15.

    Article  Google Scholar 

  21. Bardella MT, Minoli G, Radaclli F, Quentrim M, Bianehi PA, Conte D. Reevaluation of duodenal endoscopic markers in the diagnosis of celiac disease. Gastrointest Endosc. 2000;51:714–6.

    Article  PubMed  CAS  Google Scholar 

  22. Dickey W, Hughes D. Prevalence of celiac disease and its endoscopic markers among patients having routine upper gastrointestinal endoscopy. Am J Gastroenterol. 1999;94:2182–6.

    Article  PubMed  CAS  Google Scholar 

  23. Kaukinen K, Halme L, Collin P, et al. Celiac disease in patients with severe liver disease: gluten-free diet may reverse hepatic failure. Gastroenterology. 2002;122:881–8.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kochhar, R., Dutta, U., Miglani, A. et al. Celiac disease suspected at endoscopy in patients with chronic liver disease. Indian J Gastroenterol 30, 166–169 (2011). https://doi.org/10.1007/s12664-011-0106-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12664-011-0106-8

Keywords

Navigation