Abstract
Background-Aim
After a patient successfully receives a renal transplant, an increase in total serum cholesterol and triglycerides, a decrease in high density cholesterol, and normal level in low density cholesterol may be noted. Coronary artery disease is one of the main causes of morbidity and mortality in renal recipients. This study was performed in order to determine the lipid profile of patients with chronic kidney disease that received a renal transplant, and correlate the effect of the lipid profile with atherogenesis.
Patients-Methods
The study included 30 patients, of whom 21 were male and 9 female, with a mean age of 48.43 years. The lipid status of all patients was measured one month prior to transplantation and at distinct time intervals (1, 3, 6, 12 months) after transplantation. Echocardiographic (triplex) evaluation was performed in all renal recipients before transplantation and 12 months post surgery. Twenty-nine patients received a renal graft from cadaveric patients while one received a renal graft from a living relative donor. It was the first transplantation for all patients after being on the transplant waiting list for a mean 4.2 years.
Results
Measurements of the lipid profile of these patients revealed statistically significant changes after renal transplantation. Moderate atheromatous lesions were found in 50% of patients before transplantation. One year after transplantation, 18% of patients revealed no atheromatous lesions, 54% had mild atheromatous lesions and 28% had severe atheromatous lesions. Total serum cholesterol levels had statistically significant changes (P<0.001), and the grade of stenosis of carotids was also affected (p=0.0013).
Conclusion
Our results suggest that changes in the lipid status in renal transplant patients are strongly correlated with atherogenesis in carotids and, in consequence, an increased cardiovascular risk for these patients. Long-term follow-up of renal recipients can be of significant use in monitoring cardiovascular disease.
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Pistolas, D., Mpalaska, A., Koukoulaki, M. et al. Effect of lipid disorders on arteriosclerosis in renal transplant recipients. Hellenic J Surg 86, 197–202 (2014). https://doi.org/10.1007/s13126-014-0129-6
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DOI: https://doi.org/10.1007/s13126-014-0129-6