Abstract
This review presents scientific findings which indicate biomolecules are excellent candidates for the development of biopesticides. Efforts are being done to find routes to increase their concentrations in the cultivation media because this concentration facilitates applications, storage, and transportation. Some of these routes are co-fermentation and ultrasound-assisted fermentation. Ultrasonication increases metabolite production and growth rates by improvement of cell permeability and nutrient uptake rates through cell membranes. For example, 24% increase in the enzymatic activity of cellulases produced by Trichoderma reesei in solid-state fermentation was achieved with ultrasonication. Also, chitinase and β-1,3-glucanase productions were stimulated by ultrasound in Beauveria bassiana cultivation, presenting positive results. The common parameters evaluated in the production of biomolecules by ultrasound-assisted fermentation are the duty cycle, time of application, power, energetic density, and how long the sonication is maintained in the fermentation media. Many successful cases are reported and discussed, which include the final formulation of bioproducts for agricultural applications. In this trend, nanotechnology is a promising tool for the development of nanoformulations. Nanoemulsification, green synthesis, biosynthesis, or biogenic synthesis are technologies used to produce such nanoformulations, allowing the controlled release of control agents, as well as the delivery of biomolecules to specific targets.
Similar content being viewed by others
Data availability
The data will be available as requested.
References
Abdel-Razek AS, Hamed A, Frese M et al (2018) Penicisteroid C: new polyoxygenated steroid produced by co-culturing of Streptomyces piomogenus with Aspergillus niger. Steroids 138:21–25. https://doi.org/10.1016/j.steroids.2018.06.005
Abdenaceur R, Farida B, tihar, Mourad D, et al (2022) Effective biofertilizer Trichoderma spp. isolates with enzymatic activity and metabolites enhancing plant growth. Int Microbiol. https://doi.org/10.1007/s10123-022-00263-8
Abeles FB, Morgan PW, Saltveit ME (1992) Ethylene in plant biology, 2nd edn. Academic Press, San Diego
Adetunji CO, Adejumo IO, Oloke JK, Akpor OB (2018) Production of phytotoxic metabolites with bioherbicidal activities from lasiodiplodia pseudotheobromae produced on different agricultural wastes using solid-state fermentation. Iran J Sci Technol Trans A Sci 42:1163–1175. https://doi.org/10.1007/s40995-017-0369-8
Adetunji CO, Oloke JK, Bello OM et al (2019) Isolation, structural elucidation and bioherbicidal activity of an eco-friendly bioactive 2-(hydroxymethyl) phenol, from Pseudomonas aeruginosa (C1501) and its ecotoxicological evaluation on soil. Environ Technol Innov 13:304–317. https://doi.org/10.1016/j.eti.2018.12.006
Adetunji CO, Oloke JK, Phazang P, Sarin NB (2020) Influence of eco-friendly phytotoxic metabolites from Lasiodiplodia pseudotheobromae C1136 on physiological, biochemical, and ultrastructural changes on tested weeds. Environ Sci Pollut Res 27:9919–9934. https://doi.org/10.1007/S11356-020-07677-9
Akbar M, Khalil T, Andolfi A, Javaid A (2020) Isolation and identification of natural herbicidal compound from a plant pathogenic fungus, drechslera biseptata. Pak J Bot 52:2245–2249. https://doi.org/10.30848/PJB2020-6(43)
Aktas C, Ruzgar D, Gurkok S, Gormez A (2022) Purification and characterization of Stenotrophomonas maltophilia chitinase with antifungal and insecticidal properties. Prep Biochem Biotechnol 2:1–10. https://doi.org/10.1080/10826068.2022.2142942
Ali S, Charles TC, Glick BR (2014) Amelioration of high salinity stress damage by plant growth-promoting bacterial endophytes that contain ACC deaminase. Plant Physiol Biochem PPB 80:160–167. https://doi.org/10.1016/J.PLAPHY.2014.04.003
Ali SA, Khairy M, Ibrahim AA, Zohry NMH (2022) Black seed and rosemary nanoformulations as green insecticides for the granary weevil, Sitophilus granarius (L.) (Coleoptera: Curculionidae). J Food Sci. https://doi.org/10.1111/1750-3841.16186
Alves AR, Sequeira AM, Cunha (2019) Increase in bacterial biosurfactant production by co-cultivation with biofilm-forming bacteria. Lett Appl Microbiol 69:79–86. https://doi.org/10.1111/lam.13169
Amusa NA (2006) Microbially produced phytotoxins and plant disease management. Afr J Biotechnol 5:405–414. https://doi.org/10.4314/ajb.v5i5
An B, Zhang Y, Li X et al (2022) PHB2 affects the virulence of Vip3Aa to Sf9 cells through internalization and mitochondrial stability. Virulence 13:684–697. https://doi.org/10.1080/21505594.2022.2064596
Anteyi WO, Klaiber I, Rasche F (2022) Diacetoxyscirpenol, a Fusarium exometabolite, prevents efficiently the incidence of the parasitic weed Striga hermonthica. BMC Plant Biol 22:1–15. https://doi.org/10.1186/s12870-022-03471-6
Ash GJ (2010) The science, art and business of successful bioherbicides. Biol Control 52:230–240. https://doi.org/10.1016/j.biocontrol.2009.08.007
Avhad DN, Rathod VK (2015) Ultrasound assisted production of a fibrinolytic enzyme in a bioreactor. Ultrason Sonochem 22:257–264. https://doi.org/10.1016/j.ultsonch.2014.04.020
Azzollini A, Boggia L, Boccard J et al (2018) Dynamics of metabolite induction in fungal co-cultures by metabolomics at both volatile and non-volatile levels. Front Microbiol. https://doi.org/10.3389/FMICB.2018.00072
Babalola OO (2010) Beneficial bacteria of agricultural importance. Biotechnol Lett 32:1559–1570. https://doi.org/10.1007/s10529-010-0347-0
BalaKumaran MD, Ramachandran R, Balashanmugam P et al (2020) Comparative analysis of antifungal, antioxidant and cytotoxic activities of mycosynthesized silver nanoparticles and gold nanoparticles. Mater Technol 37:411–421. https://doi.org/10.1080/10667857.2020.1854518
Balasundaram B, Harrison S, Bracewell DG (2009) Advances in product release strategies and impact on bioprocess design. Trends Biotechnol 27:477–485. https://doi.org/10.1016/J.TIBTECH.2009.04.004
Banerjee M, Yesmin L, Vessey J, Rai M (2006) Plant-growth-promoting rhizobacteria as biofertilizers and biopesticides. Handbook of Microbial biofertilizers. CRC Press, Boca Raton, pp 165–210
Barbu LDN, Boiu-Sicuia O-A (2021) Plant-beneficial microbial inoculants and their formulation—a review. Rom J Plant Prot 14:32–43. https://doi.org/10.54574/rjpp.14.05
Barnawal D, Bharti N, Maji D et al (2012) 1-Aminocyclopropane-1-carboxylic acid (ACC) deaminase-containing rhizobacteria protect Ocimum sanctum plants during waterlogging stress via reduced ethylene generation. Plant Physiol Biochem 58:227–235. https://doi.org/10.1016/J.PLAPHY.2012.07.008
Bastos BO, Deobald GA, Brun T et al (2017) Solid-state fermentation for production of a bioherbicide from Diaporthe sp. and its formulation to enhance the efficacy. 3 Biotech 7:1–9. https://doi.org/10.1007/S13205-017-0751-4/FIGURES/6
Behzadnia A, Moosavi-Nasab M, Ojha S, Tiwari BK (2020) Exploitation of ultrasound technique for enhancement of microbial metabolites production. Molecules 25:1–16. https://doi.org/10.3390/molecules25225473
Bérdy J (2012) Thoughts and facts about antibiotics: Where we are now and where we are heading. J Antibiot 658(65):385–395. https://doi.org/10.1038/ja.2012.27
Berestetskiy AO (2008) A review of fungal phytotoxins: from basic studies to practical use. Appl Biochem Microbiol 44:453–465. https://doi.org/10.1134/S0003683808050013
Berestetskiy AO, Poluektova EV, Sabashuk YA, Pervushin AL (2019) Development of chromatography techniques for analysis and preparative isolation of phytotoxic metabolites produced by Stagonospora cirsii. Appl Biochem Microbiol 55:684–690. https://doi.org/10.1134/S000368381906005X
Bertrand S, Bohni N, Schnee S et al (2014) Metabolite induction via microorganism co-culture: a potential way to enhance chemical diversity for drug discovery. Biotechnol Adv 32:1180–1204. https://doi.org/10.1016/j.biotechadv.2014.03.001
Bode HB, Bethe B, Höfs R, Zeeck A (2002) Big effects from small changes: possible ways to explore nature’s chemical diversity. ChemBioChem 3:619–627. https://doi.org/10.1002/1439-7633(20020703)3:7%3c619::AID-CBIC619%3e3.0.CO;2-9
Boruta T, Milczarek I (2019) Evaluating the outcomes of submerged co-cultivation: production of lovastatin and other secondary metabolites by Aspergillus terreus in fungal co-cultures. Appl Microbiol Biotechnol 10314(103):5593–5605. https://doi.org/10.1007/S00253-019-09874-0
Bouchard-Rochette M, Machrafi Y, Cossus L et al (2022) Bacillus pumilus PTB180 and Bacillus subtilis PTB185: Production of lipopeptides, antifungal activity, and biocontrol ability against Botrytis cinerea. Biol Control 170:104925. https://doi.org/10.1016/j.biocontrol.2022.104925
Boyetchko S, Pedersen E, Punja Z, Reddy M (2003) Formulations of biopesticides. Biopesticides. Humana Press, Boca Raton, pp 487–508
Brun T, Rabuske JE, Confortin TC et al (2020) Weed control by metabolites produced from Diaporthe schini. Environ Technol 43:139–148. https://doi.org/10.1080/09593330.2020.1780477
Carrière Y, Crickmore N, Tabashnik BE (2015) Optimizing pyramided transgenic Bt crops for sustainable pest management. Nat Biotechnol 33:161–168. https://doi.org/10.1038/nbt.3099
Chakroun M, Ferré J (2014) In vivo and in vitro binding of Vip3Aa to Spodoptera frugiperda midgut and characterization of binding sites by 125I radiolabeling. Appl Environ Microbiol 80:6258–6265. https://doi.org/10.1128/AEM.01521-14
Charnley AK (2003) Fungal pathogens of insects: cuticle degrading enzymes and toxins. Advances in botanical research. Academic Press, New York, pp 241–321
Charudattan R (2010) A reflection on my research in weed biological control: using what we have learned for future applications. Weed Technol 24:208–217. https://doi.org/10.1614/wt-d-09-00012.1
Chen H, Daletos G, Abdel-Aziz MS et al (2015) Inducing secondary metabolite production by the soil-dwelling fungus Aspergillus terreus through bacterial co-culture. Phytochem Lett 12:35–41. https://doi.org/10.1016/j.phytol.2015.02.009
Chen H, Singh H, Bhardwaj N et al (2020a) An exploration on the toxicity mechanisms of phytotoxins and their potential utilities. Crit Rev Environ Sci Technol 52:395–435. https://doi.org/10.1080/10643389.2020.1823172
Chen J, Li Z, Cheng Y et al (2020b) Sphinganine-analog mycotoxins (Sams): chemical structures, bioactivities, and genetic controls. J Fungi 6:1–34. https://doi.org/10.3390/jof6040312
Chen K, Tian Z, He H et al (2020c) Bacillus species as potential biocontrol agents against citrus diseases. Biol Control 151:104419. https://doi.org/10.1016/j.biocontrol.2020c.104419
Chhipa H (2019) Mycosynthesis of nanoparticles for smart agricultural practice: a green and eco-friendly approach. Green synthesis, characterization and applications of nanoparticles. Elsevier, Amsterdam, pp 87–109
Chisti Y (2003) Sonobioreactors: using ultrasound for enhanced microbial productivity. Trends Biotechnol 21:89–93. https://doi.org/10.1016/S0167-7799(02)00033-1
Chuanyun D, Bochu W, Chuanren D, Sakanishi A (2003) Low ultrasonic stimulates fermentation of riboflavin producing strain Ecemothecium ashbyii. Colloids Surf B Biointerf 30:37–41. https://doi.org/10.1016/S0927-7765(03)00022-5
Chugh G, Siddique KHM, Solaiman ZM (2021) Nanobiotechnology for agriculture: Smart technology for combating nutrient deficiencies with nanotoxicity challenges. Sustainability 13:1–20. https://doi.org/10.3390/su13041781
Cimmino A, Masi M, Evidente M et al (2015) Fungal phytotoxins with potential herbicidal activity: chemical and biological characterization. Nat Prod Rep 32:1629–1653. https://doi.org/10.1039/c5np00081e
Cordeau S, Triolet M, Wayman S et al (2016) Bioherbicides: dead in the water? A review of the existing products for integrated weed management. Crop Prot 87:44–49. https://doi.org/10.1016/j.cropro.2016.04.016
Cui B, Li J, Lai Z et al (2021) Emamectin benzoate-loaded zein nanoparticles produced by antisolvent precipitation method. Polym Test 94:107020. https://doi.org/10.1016/j.polymertesting.2020.107020
Dahroud BD, Mokarram RR, Khiabani MS et al (2016) Low intensity ultrasound increases the fermentation efficiency of Lactobacillus casei subsp.casei ATTC 39392. Int J Biol Macromol 86:462–467. https://doi.org/10.1016/j.ijbiomac.2016.01.103
Degani O, Khatib S, Becher P et al (2021) Trichoderma asperellum secreted 6-pentyl-α-pyrone to control magnaporthiopsis maydis, the maize late wilt disease agent. Biology. https://doi.org/10.3390/biology10090897
Doran PM (2012) Bioprocess engineering principles, 2nd edn.
Du L, Xu Q, Huang M et al (2015a) Synthesis of small silver nanoparticles under light radiation by fungus Penicillium oxalicum and its application for the catalytic reduction of methylene blue. Mater Chem Phys 160:40–47. https://doi.org/10.1016/j.matchemphys.2015.04.003
Du Y, Kopittke PM, Noller BN et al (2015b) In situ analysis of foliar zinc absorption and short-distance movement in fresh and hydrated leaves of tomato and citrus using synchrotron-based X-ray fluorescence microscopy. Ann Bot 115:41–53. https://doi.org/10.1093/AOB/MCU212
Duke SO, Owens DK, Dayan FE (2014) The growing need for biochemical bioherbicides. ACS Symp Ser 1172:31–43. https://doi.org/10.1021/bk-2014-1172.ch003
Durbin RD (1991) Bacterial phytotoxins: mechanisms of action. Experientia 47:776–783. https://doi.org/10.1007/BF01922457
Ealias AM, Saravanakumar MP (2017) A review on the classification, characterisation, synthesis of nanoparticles and their application. IOP Conf Ser Mater Sci Eng. https://doi.org/10.1088/1757-899X/263/3/032019
Elgorban AM, Aref SM, Seham SM et al (2016) Extracellular synthesis of silver nanoparticles using Aspergillus versicolor and evaluation of their activity on plant pathogenic fungi. Mycosphere 7:844–852. https://doi.org/10.5943/mycosphere/7/6/15
Estruch JJ, Warren GW, Mullins MA et al (1996) Vip3A, a novel Bacillus thuringiensis vegetative insecticidal protein with a wide spectrum of activities against lepidopteran insects. Proc Natl Acad Sci U S A 93:5389–5394. https://doi.org/10.1073/pnas.93.11.5389
Evidente A, Cimmino A, Masi M (2019) Phytotoxins produced by pathogenic fungi of agrarian plants. Phytochem Rev 18:843–870. https://doi.org/10.1007/s11101-019-09624-0
Feng J, Ma Y, Chen Z et al (2021) Development and characterization of pyriproxyfen-loaded nanoemulsion for housefly control: improving activity, reducing toxicity, and protecting ecological environment. ACS Sustain Chem Eng 9:4988–4999. https://doi.org/10.1021/acssuschemeng.0c08105
Fuchino K, Bruheim P (2020) An assessment of serial co-cultivation approach for generating novel Zymomonas mobilis strains. BMC Res Notes 13:1–6. https://doi.org/10.1186/S13104-020-05261-5
Gasic S, Tanovic B (2013) Biopesticide formulations, possibility of application and future trends. Pestic i Fitomedicina 28:97–102. https://doi.org/10.2298/PIF1302097G
Ghazy OA, Fouad MT, Saleh HH et al (2021) Ultrasound-assisted preparation of anise extract nanoemulsion and its bioactivity against different pathogenic bacteria. Food Chem 341:128259. https://doi.org/10.1016/j.foodchem.2020.128259
Glick BR (2014) Bacteria with ACC deaminase can promote plant growth and help to feed the world. Microbiol Res 169:30–39. https://doi.org/10.1016/j.micres.2013.09.009
Glick BR, Penrose DM, Li J (1998) A model for the lowering of plant ethylene concentrations by plant growth-promoting bacteria. J Theor Biol 190:63–68. https://doi.org/10.1006/jtbi.1997.0532
Glick BR, Cheng Z, Czarny J, Duan J (2007) Promotion of plant growth by ACC deaminase-producing soil bacteria. New Perspect Approaches Plant Growth-Promoting Rhizobacteria Res 2:329–339. https://doi.org/10.1007/978-1-4020-6776-1_8/COVER
Gouffon C, Van Vliet A, Van Rie J et al (2011) Binding sites for Bacillus thuringiensis Cry2Ae toxin on heliothine brush border membrane vesicles are not shared with Cry1A, Cry1F, or Vip3A toxin. Appl Environ Microbiol 77:3182–3188. https://doi.org/10.1128/AEM.02791-10
Guilger-Casagrande M, de Lima R (2019) Synthesis of silver nanoparticles mediated by fungi: a review. Front Bioeng Biotechnol 7:1–16. https://doi.org/10.3389/fbioe.2019.00287
Han JW, Kim B, Oh M et al (2020) The antifungal test: an efficient screening tool for the discovery of microbial metabolites with respiratory inhibitory activity. Mycobiology 48:326–329. https://doi.org/10.1080/12298093.2020.1766648
Hawkins AP, Crawford KM (2018) Interactions between plants and soil microbes may alter the relative importance of intraspecific and interspecific plant competition in a changing climate. AoB Plants 2:1–11. https://doi.org/10.1093/aobpla/ply039
Hazrati H, Saharkhiz MJ, Niakousari M, Moein M (2017) Natural herbicide activity of Satureja hortensis L. essential oil nanoemulsion on the seed germination and morphophysiological features of two important weed species. Ecotoxicol Environ Saf 142:423–430. https://doi.org/10.1016/j.ecoenv.2017.04.041
He J, Qiu Y, Ji X et al (2021) A novel strategy for producing cellulase from Trichoderma reesei with ultrasound-assisted fermentation using spent mushroom substrate. Process Biochem 104:110–116. https://doi.org/10.1016/j.procbio.2021.03.015
He W, Li Y, Luo W et al (2022) Herbicidal secondary metabolites from Bacillus velezensis JTB8–2 against Orobanche aegyptiaca. AMB Express. https://doi.org/10.1186/s13568-022-01395-w
Hernández-Martínez P, Gomis-Cebolla J, Ferré J, Escriche B (2017) Changes in gene expression and apoptotic response in Spodoptera exigua larvae exposed to sublethal concentrations of Vip3 insecticidal proteins. Sci Rep 7:1–12. https://doi.org/10.1038/s41598-017-16406-1
Herrán NS, López JLC, Pérez JAS, Chisti Y (2008) Effects of ultrasound on culture of Aspergillus terreus. J Chem Technol Biotechnol 83:593–600. https://doi.org/10.1002/jctb.1821
Hess FD, Foy CL (2000) Interaction of surfactants with plant cuticles. Weed Technol 14:807–813
Horbach R, Navarro-Quesada AR, Knogge W, Deising HB (2011) When and how to kill a plant cell: Infection strategies of plant pathogenic fungi. J Plant Physiol 168:51–62. https://doi.org/10.1016/j.jplph.2010.06.014
Hoshino S, Onaka H, Abe I (2019) Activation of silent biosynthetic pathways and discovery of novel secondary metabolites in actinomycetes by co-culture with mycolic acid-containing bacteria. J Ind Microbiol Biotechnol 46:363–374. https://doi.org/10.1007/S10295-018-2100-Y
Hou X, Han L, An B et al (2020) Mitochondria and lysosomes participate in Vip3Aa-induced spodoptera frugiperda Sf9 cell apoptosis. Toxins. https://doi.org/10.3390/toxins12020116
Huang G, Chen S, Dai C et al (2017) Effects of ultrasound on microbial growth and enzyme activity. Ultrason Sonochem 37:144–149. https://doi.org/10.1016/j.ultsonch.2016.12.018
Hubbard M, Taylor WG, Bailey KL, Hynes RK (2016) The dominant modes of action of macrocidins, bioherbicidal metabolites of Phoma macrostoma, differ between susceptible plant species. Environ Exp Bot 132:80–91. https://doi.org/10.1016/J.ENVEXPBOT.2016.08.009
Iqbal N, Hazra DK, Purkait A et al (2022) Bioengineering of neem nano-formulation with adjuvant for better adhesion over applied surface to give long term insect control. Colloids Surf B Biointerf 209:112176. https://doi.org/10.1016/j.colsurfb.2021.112176
Ivănescu B, Burlec A, Crivoi F et al (2021) Secondary metabolites from artemisia genus as biopesticides. Molecules 26:3061
Iwai Y, Ömura S (1982) Culture conditions for screening of new antibiotics. J Antibiot (tokyo) 35:123–141. https://doi.org/10.7164/antibiotics.35.123
Jahanshahi M (2004) Re-design of downstream processing techniques for nanoparticulate bioproducts. Iran J Biotechnol 2:1–12
Jangir M, Sharma S, Sharma S (2021) Development of next-generation formulation against Fusarium oxysporum and unraveling bioactive antifungal metabolites of biocontrol agents. Sci Rep 11:1–15. https://doi.org/10.1038/s41598-021-02284-1
Jiang K, Mei S, Wang T et al (2016) Vip3Aa induces apoptosis in cultured Spodoptera frugiperda (Sf9) cells. Toxicon 120:49–56. https://doi.org/10.1016/j.toxicon.2016.07.019
Jin CW, Ye YQ, Zheng SJ (2014) An underground tale: contribution of microbial activity to plant iro. Ann Bot 113:7–18. https://doi.org/10.1093/aob/mct249
Kamdem RSTT, Wang H, Wafo P et al (2018) Induction of new metabolites from the endophytic fungus Bionectria sp. through bacterial co-culture. Fitoterapia 124:132–136. https://doi.org/10.1016/j.fitote.2017.10.021
Kamil D, Prameeladevi T, Ganesh S et al (2017) Green synthesis of silver nanoparticles by entomopathogenic fungus Beauveria bassiana and their bioefficacy against mustard aphid (Lipaphis erysimi Kalt.). Indian J Exp Biol 55:555–561
Karuppiah V, Sun J, Li T et al (2019) Co-cultivation of trichoderma asperellum GDFS1009 and bacillus amyloliquefaciens 1841 causes differential gene expression and improvement in the wheat growth and biocontrol activity. Front Microbiol 10:1–16. https://doi.org/10.3389/fmicb.2019.01068
Karuppiah V, Li Y, Sun J et al (2020) Vel1 regulates the growth of Trichoderma atroviride during co-cultivation with Bacillus amyloliquefaciens and is essential for wheat root rot control. Biol Control. https://doi.org/10.1016/j.biocontrol.2020.104374
Kaur PK, Kaur J, Saini HS (2015) Antifungal potential of Bacillus vallismortis R2 against different phytopathogenic fungi. Spanish J Agric Res 13:1–11. https://doi.org/10.5424/sjar/2015132-6620
Kaur PK, Joshi N, Singh IP, Saini HS (2017) Identification of cyclic lipopeptides produced by Bacillus vallismortis R2 and their antifungal activity against Alternaria alternata. J Appl Microbiol 122:139–152. https://doi.org/10.1111/jam.13303
Kaur P, Gupta S, Kaur K et al (2021) Nanoemulsion of Foeniculum vulgare essential oil: a propitious striver against weeds of Triticum aestivum. Ind Crops Prod 168:113601. https://doi.org/10.1016/j.indcrop.2021.113601
Khan A, Jilani G, Saleem Akhtar M et al (2009) Phosphorus solubilizing bacteria: occurrence, mechanisms and their role in crop production. J Agric Biol Sci 1:48–58
Khan I, Saeed K, Khan I (2019) Nanoparticles: properties, applications and toxicities. Arab J Chem 12:908–931. https://doi.org/10.1016/j.arabjc.2017.05.011
Kim BS, Hwang BK (2007) Microbial fungicides in the control of plant diseases. J Phytopathol 155:641–653. https://doi.org/10.1111/j.1439-0434.2007.01314.x
Kim HJ, Bo AB, Kim JD et al (2020) Herbicidal characteristics and structural identification of the potential active compounds from Streptomyces sp. KRA17-580. J Agric Food Chem 68:15373–15380. https://doi.org/10.1021/acs.jafc.0c01974
Klaic R, Kuhn RC, Foletto EL et al (2015) An overview regarding bioherbicide and their production methods by fermentation. Fungal Biomol Sour Appl Recent Dev 2:183–199. https://doi.org/10.1002/9781118958308.ch14
Klaic R, Sallet D, Foletto EL et al (2017) Optimization of solid-state fermentation for bioherbicide production by Phoma sp. Braz J Chem Eng 34:377–384. https://doi.org/10.1590/0104-6632.20170342S20150613
Kossuga MH, Ferreira AG, Sette LD, Berlinck RGS (2013) Two polyketides from a co-culture of two marine-derived fungal strains. Nat Prod Commun 8:721–724. https://doi.org/10.1177/1934578X1300800610
Kremer RJ (2005) The role of bioherbicides in weed management. Biopestic Int 1:127–141
Kremer RJ (2019) Bioherbicides and nanotechnology: current status and future trends. Nano-Biopest Today Futur Perspect. https://doi.org/10.1016/B978-0-12-815829-6.00015-2
Kumar S, Bhanjana G, Sharma A et al (2017) Development of nanoformulation approaches for the control of weeds. Sci Total Environ 586:1272–1278. https://doi.org/10.1016/j.scitotenv.2017.02.138
Kumar A, Kanwar R, Mehta SK (2021) Eucalyptus oil-based nanoemulsion: a potent green nanowagon for controlled delivery of emamectin benzoate. ACS Agric Sci Technol 1:76–88. https://doi.org/10.1021/acsagscitech.0c00061
Kumar A, Kanwar R, Mehta SK (2022) Development of Phosphatidylcholine/Tween 80 based biocompatible clove oil-in-water nanoemulsion as a green nanocarrier for controlled herbicide delivery. Environ Pollut 293:118558. https://doi.org/10.1016/j.envpol.2021.118558
Lázaro-Berenguer M, Paredes-Martínez F, Bel Y et al (2022) Structural and functional role of Domain I for the insecticidal activity of the Vip3Aa protein from Bacillus thuringiensis. Microb Biotechnol. https://doi.org/10.1111/1751-7915.14110
Lee MK, Miles P, Chen JS (2006) Brush border membrane binding properties of Bacillus thuringiensis Vip3A toxin to Heliothis virescens and Helicoverpa zea midguts. Biochem Biophys Res Commun 339:1043–1047. https://doi.org/10.1016/j.bbrc.2005.11.112
Li P, Huang Y, Fu C et al (2021) Eco-friendly biomolecule-nanomaterial hybrids as next-generation agrochemicals for topical delivery. EcoMat. https://doi.org/10.1002/eom2.12132
Liu F, Xu Z, Zhu YC et al (2010) Evidence of field-evolved resistance to Cry1Ac-expressing Bt cotton in Helicoverpa armigera (Lepidoptera: Noctuidae) in northern China. Pest Manag Sci 66:155–161. https://doi.org/10.1002/ps.1849
Liu S, Dai H, Heering C et al (2017) Inducing new secondary metabolites through co-cultivation of the fungus Pestalotiopsis sp. with the bacterium Bacillus subtilis. Tetrahedron Lett 58:257–261. https://doi.org/10.1016/j.tetlet.2016.12.026
Liu Y, Teng K, Wang T et al (2020) Antimicrobial Bacillus velezensis HC6: production of three kinds of lipopeptides and biocontrol potential in maize. J Appl Microbiol 128:242–254. https://doi.org/10.1111/jam.14459
Lowry GV, Avellan A (2019) Gilbertson LM (2019) Opportunities and challenges for nanotechnology in the agri-tech revolution. Nat Nanotechnol 146(14):517–522. https://doi.org/10.1038/s41565-019-0461-7
Lu H, Lou H, Wei T et al (2020) Ultrasound enhanced production of mycelia and exopolysaccharide by Agaricus bitorquis (Quél) Sacc Chaidam. Ultrason Sonochem. https://doi.org/10.1016/j.ultsonch.2020.105040
Lu P, Jiang K, Hao YQ et al (2021) Profiles of Bacillus spp. Isolated from the rhizosphere of Suaeda glauca and their potential to promote plant growth and suppress fungal phytopathogens. J Microbiol Biotechnol 31:1231–1240. https://doi.org/10.4014/jmb.2105.05010
Lyddiatt A, O’Sullivan DA (1998) Biochemical recovery and purification of gene therapy vectors. Curr Opin Biotechnol 9:177–185. https://doi.org/10.1016/S0958-1669(98)80112-2
Machado AR, Baron NC, Kadasamy S, Rigobelo EC (2020) Formulation and pathogenicity of a bioherbicide for wild poinsettia control. Afr J Microbiol Res 14:129–135. https://doi.org/10.5897/ajmr2020.9321
Macías-Rubalcava ML, Monserrat N, Garrido-Santos Y (2022) Phytotoxic compounds from endophytic fungi. Appl Microbiol Biotechnol 2022:1–20. https://doi.org/10.1007/S00253-022-11773-W
Maddikeri GL, Gogate PR, Pandit AB (2015) Improved synthesis of sophorolipids from waste cooking oil using fed batch approach in the presence of ultrasound. Chem Eng J 263:479–487. https://doi.org/10.1016/J.CEJ.2014.11.010
Majeed A, Ullah W, Anwar AW et al (2018) Cost-effective biosynthesis of silver nanoparticles using different organs of plants and their antimicrobial applications: a review. Mater Technol 33:313–320. https://doi.org/10.1080/10667857.2015.1108065
Martinez-Guerra E, Gude VG, Mondala A et al (2014) Microwave and ultrasound enhanced extractive-transesterification of algal lipids. Appl Energy 129:354–363. https://doi.org/10.1016/J.APENERGY.2014.04.112
Mazhar T, Shrivastava V, Tomar RS (2017) Green synthesis of bimetallic nanoparticles and its applications: a review. J Pharm Sci Res 9:102–110. https://doi.org/10.1016/j.scp.2021.100547
Mejri S, Siah A, Coutte F et al (2018) Biocontrol of the wheat pathogen Zymoseptoria tritici using cyclic lipopeptides from Bacillus subtilis. Environ Sci Pollut Res 25:29822–29833. https://doi.org/10.1007/s11356-017-9241-9
Mezadri ET, Kuhn KR, Schmaltz S et al (2022) Evaluation of ultrasound waves for the production of chitinase and β-1,3 glucanase by Trichoderma harzianum through SSF. Biotech 12:1–9. https://doi.org/10.1007/s13205-022-03179-2
Möbius N, Hertweck C (2009) Fungal phytotoxins as mediators of virulence. Curr Opin Plant Biol 12:390–398. https://doi.org/10.1016/j.pbi.2009.06.004
Moghaddam HS, Shahnavaz B, Makhdoumi A, Iranshahy M (2021) Evaluating the effect of various bacterial consortia on antibacterial activity of marine Streptomyces sp AC117. Biocontrol Sci Technol. https://doi.org/10.1080/09583157.2021.1940865
Mohiddin FA, Padder SA, Bhat AH et al (2021) Phylogeny and optimization of trichoderma harzianum for chitinase production: evaluation of their antifungal behaviour against the prominent soil borne phyto-pathogens of temperate India. Microorganisms. https://doi.org/10.3390/microorganisms9091962
Morin L (2020) Progress in biological control of weeds with plant pathogens. Annu Rev Phytopathol 58:201–223. https://doi.org/10.1146/annurev-phyto-010820-012823
Muthuvelu KS, Arumugasamy SK (2019) Chromatography. Bioprocess Engineering: Downstream Processing. CRC Press, Boca Raton
Naveena B, Armshaw P, Pembroke TJ (2015) Ultrasonic intensification as a tool for enhanced microbial biofuel yields. Biotechnol Biofuels 8:1–13. https://doi.org/10.1186/s13068-015-0321-0
Ngalimat MS, Yahaya RSR, Baharudin MMAA et al (2021) A review on the biotechnological applications of the operational group bacillus amyloliquefaciens. Microorganisms 9:1–18. https://doi.org/10.3390/microorganisms9030614
Nimsanor S, Srisaisup M, Jammor P et al (2020) Intracellular localization and cytotoxicity of Bacillus thuringiensis Vip3Aa against Spodoptera frugiperda (Sf9) cells. J Invertebr Pathol 171:107340. https://doi.org/10.1016/j.jip.2020.107340
Nishimoto R (2019) Global trends in the crop protection industry. J Pestic Sci 44:141–147. https://doi.org/10.1584/JPESTICS.D19-101
Nuruzzaman M, Rahman MM, Liu Y, Naidu R (2016) Nanoencapsulation, nano-guard for pesticides: a new window for safe application. J Agric Food Chem 64:1447–1483. https://doi.org/10.1021/acs.jafc.5b05214
Ojha KS, Mason TJ, O’Donnell CP et al (2017) Ultrasound technology for food fermentation applications. Ultrason Sonochem 34:410–417
Olanrewaju OS, Glick BR, Babalola OO (2017) Mechanisms of action of plant growth promoting bacteria. World J Microbiol Biotechnol. https://doi.org/10.1007/s11274-017-2364-9
Omidi A, Esterhuizen-Londt M, Pflugmacher S (2019) Interspecies interactions between Microcystis aeruginosa PCC 7806 and Desmodesmus subspicatus SAG 86.81 in a co-cultivation system at various growth phases. Environ Int 131:105052. https://doi.org/10.1016/j.envint.2019.105052
Ouyang Y, Chen S, Zhao L et al (2021) Global metabolomics reveals that vibrio natriegens enhances the growth and paramylon synthesis of Euglena gracilis. Front Bioeng Biotechnol 9:1–11. https://doi.org/10.3389/fbioe.2021.652021
Pallavi CD, Sharma AK (2017) Commercial microbial products: exploiting beneficial plant-microbe interaction. Plant-Microbe Interact Agro-Ecol Perspect 2:607–626. https://doi.org/10.1007/978-981-10-6593-4_25
Pandey A (2003) Solid-state fermentation. Biochem Eng J 13:81–84. https://doi.org/10.1007/978-3-319-10464-5_10
Pardo-López L, Soberón M, Bravo A (2013) Bacillus thuringiensis insecticidal three-domain Cry toxins: mode of action, insect resistance and consequences for crop protection. FEMS Microbiol Rev 37:3–22. https://doi.org/10.1111/j.1574-6976.2012.00341.x
Parisi C, Vigani M, Rodríguez-Cerezo E (2015) Agricultural nanotechnologies: what are the current possibilities? Nano Today 10:124–127. https://doi.org/10.1016/J.NANTOD.2014.09.009
Pawar S, Rathod V (2022) Comparative bioreactor studies of different process enhancement methods in B. licheniformis for enzyme co-production. Prep Biochem Biotechnol. https://doi.org/10.1080/10826068.2022.2033991
Pérez-Montaño F, Alías-Villegas C, Bellogín RA et al (2014) Plant growth promotion in cereal and leguminous agricultural important plants: from microorganism capacities to crop production. Microbiol Res 169:325–336. https://doi.org/10.1016/J.MICRES.2013.09.011
Piyaboon O, Pawongrat R, Unartngam J et al (2016) Pathogenicity, host range and activities of a secondary metabolite and enzyme from Myrothecium roridum on water hyacinth from Thailand. Weed Biol Manag 16:132–144. https://doi.org/10.1111/wbm.12104
Quan Y, Lázaro-Berenguer M, Hernández-Martínez P, Ferré J (2021) Critical domains in the specific binding of radiolabeled Vip3Af insecticidal protein to brush border membrane vesicles from Spodoptera spp. and cultured insect cells. Appl Environ Microbiol 87:1–13
Rajan R, Chandran K, Harper SL et al (2015) Plant extract synthesized silver nanoparticles: an ongoing source of novel biocompatible materials. Ind Crops Prod 70:356–373. https://doi.org/10.1016/j.indcrop.2015.03.015
Ramalakshmi S (2019) Cell Disruption. Bioprocess engineering: downstream processing. CRC Press, Boca Raton
Reveglia P, Savocchia S, Billones-Baaijens R et al (2019) Phytotoxic metabolites by nine species of Botryosphaeriaceae involved in grapevine dieback in Australia and identification of those produced by Diplodia mutila, Diplodia seriata, Neofusicoccum australe and Neofusicoccum luteum. Nat Prod Res 33:2223–2229. https://doi.org/10.1080/14786419.2018.1497631/SUPPL_FILE/GNPL_A_1497631_SM9502.PDF
Rokhina EV, Lens P, Virkutyte J (2009) Low-frequency ultrasound in biotechnology: state of the art. Trends Biotechnol 27:298–306. https://doi.org/10.1016/j.tibtech.2009.02.001
Saad MMG, Abdelgaleil SAM, Shiono Y (2020) Antibacterial and herbicidal properties of secondary metabolites from fungi. Nat Prod Res. https://doi.org/10.1080/14786419.2020.1779718
Sari M, Kusharyoto W, Brazia AC (2020) Profiling bioactive compounds in secondary metabolites from co-cultivation between actinomycetes and pathogenic bacteria. IOP Conf Ser Earth Environ Sci 439:012009. https://doi.org/10.1088/1755-1315/439/1/012009
Schmaltz S, Aita BC, Alves EA et al (2020) Ultrasound-assisted fermentation for production of β-1,3-glucanase and chitinase by Beauveria bassiana. J Chem Technol Biotechnol 96:88–98. https://doi.org/10.1002/jctb.6514
Schnepf E, Crickmore N, Van Rie J et al (1998) Bacillus thuringiensis and its pesticidal crystal proteins. Microbiol Mol Biol Rev 62:775–806
Sena JAD, Hernández-Rodríguez CS, Ferré J (2009) Interaction of Bacillus thuringiensis Cry1 and Vip3A proteins with Spodoptera frugiperda midgut binding sites. Appl Environ Microbiol 75:2236–2237. https://doi.org/10.1128/AEM.02342-08
Shah D, Khan MS, Aziz S et al (2022) Molecular and biochemical characterization, antimicrobial activity, stress tolerance, and plant growth-promoting effect of endophytic bacteria isolated from wheat varieties. Microorganisms. https://doi.org/10.3390/microorganisms10010021
Shang Z, Salim AA, Capon RJ (2017) Chaunopyran A: co-cultivation of marine mollusk-derived fungi activates a rare class of 2-alkenyl-tetrahydropyran. J Nat Prod 80:1167–1172. https://doi.org/10.1021/ACS.JNATPROD.7B00144
Shobha B, Lakshmeesha TR, Ansari MA et al (2020) Mycosynthesis of zno nanoparticles using Trichoderma spp. Isolated from rhizosphere soils and its synergistic antibacterial effect against Xanthomonas oryzae pv. oryzae. J Fungi 6:1–19. https://doi.org/10.3390/jof6030181
Shoresh M, Yedidia I, Chet I (2005) Involvement of jasmonic acid/ethylene signaling pathway in the systemic resistance induced in cucumber by Trichoderma asperellum T203. Phytopathology 95:76–84. https://doi.org/10.1094/PHYTO-95-0076
Show PL, Ooi CW, Ling TC (2019) Bioprocess engineering downstream processing. CRC Press, Boca Raton
Sinisterra JV (1992) Application of ultrasound to biotechnology: an overview. Ultrasonics 30:180–185. https://doi.org/10.1016/0041-624X(92)90070-3
Song R, Shen G, Liu Y et al (2020) Preparation and characterization of an oil-in-water microemulsion of thiamethoxam and acetamiprid without organic solvent for unmanned aerial vehicle spraying. Colloids Surfaces A Physicochem Eng 607:125485. https://doi.org/10.1016/j.colsurfa.2020.125485
Spaepen S, Vanderleyden J, Remans R (2007) Indole-3-acetic acid in microbial and microorganism-plant signaling. FEMS Microbiol Rev 31:425–448. https://doi.org/10.1111/j.1574-6976.2007.00072.x
Stenberg JA, Sundh I, Becher PG et al (2004) (2021) When is it biological control? A framework of definitions, mechanisms, and classifications. J Pest Sci 1:3. https://doi.org/10.1007/s10340-021-01354-7
Storer NP, Babcock JM, Schlenz M et al (2010) Discovery and characterization of field resistance to Bt maize: Spodoptera frugiperda (Lepidoptera: Noctuidae) in Puerto Rico. J Econ Entomol 103:1031–1038. https://doi.org/10.1603/EC10040
Strange RN (2007) Phytotoxins produced by microbial plant pathogens. Nat Prod Rep 24:127–144. https://doi.org/10.1039/b513232k
Strange RN, Scott PR (2005) Plant disease: a threat to global food security. Annu Rev Phytopathol 43:83–116. https://doi.org/10.1146/ANNUREV.PHYTO.43.113004.133839
Strobel GA (1977) Bacterial phytotoxins. Annu Rev Microbiol 31:205–224. https://doi.org/10.1146/annurev.mi.31.100177.001225
Ström K, Schnürer J, Melin P (2005) Co-cultivation of antifungal Lactobacillus plantarum MiLAB 393 and Aspergillus nidulans, evaluation of effects on fungal growth and protein expression. FEMS Microbiol Lett 246:119–124. https://doi.org/10.1016/J.FEMSLE.2005.03.047
Styczynski M, Biegniewski G, Decewicz P et al (2022) Application of psychrotolerant antarctic bacteria and their metabolites as efficient plant growth promoting agents. Front Bioeng Biotechnol 10:1–19. https://doi.org/10.3389/fbioe.2022.772891
Su Y, Ashworth V, Kim C et al (2019) Delivery, uptake, fate, and transport of engineered nanoparticles in plants: a critical review and data analysis. Environ Sci Nano 6:2311–2331. https://doi.org/10.1039/C9EN00461K
Sun C, Li X, Xiao Z et al (2022) Cyclosporin A acts as an insecticide candidate: providing sustainable biocontrol potential for managing Mythimna separata. J Pest Sci. https://doi.org/10.1007/s10340-022-01577-2
Szotkowski M, Holub J, Šimanský S et al (2021) Bioreactor Co-cultivation of high lipid and carotenoid producing yeast rhodotorula kratochvilovae and several microalgae under stress. Microorg 9:1160. https://doi.org/10.3390/MICROORGANISMS9061160
Tabashnik BE, Carrière Y (2017) Surge in insect resistance to transgenic crops and prospects for sustainability. Nat Biotechnol 35:926–935. https://doi.org/10.1038/nbt.3974
Tabashnik BE, Gassmann AJ, Crowder DW, Carrière Y (2008) Insect resistance to Bt crops: evidence versus theory. Nat Biotechnol 26:199–202. https://doi.org/10.1038/nbt1382
Tizazu BZ, Roy K, Moholkar VS (2018) Mechanistic investigations in ultrasound-assisted xylitol fermentation. Ultrason Sonochem 48:321–328. https://doi.org/10.1016/j.ultsonch.2018.06.014
Triolet M, Guillemin JP, Andre O, Steinberg C (2019) Fungal-based bioherbicides for weed control: a myth or a reality? Weed Res 60:60–77. https://doi.org/10.1111/wre.12389
Turan M, Kıtır N, Alkaya Ü et al (2016) Making soil more accessible to plants: the case of plant growth promoting rhizobacteria. Plant Growth. https://doi.org/10.5772/64826
Umego EC, He R, Huang G et al (2021) Ultrasound-assisted fermentation: mechanisms, technologies, and challenges. J Food Process Preserv. https://doi.org/10.1111/jfpp.15559
Umurzokov M, Lee YM, Kim HJ et al (2022) Herbicidal characteristics and structural identification of a potential active compound produced by Streptomyces sp KRA18–249. Pestic Biochem Physiol 187:105213. https://doi.org/10.1016/j.pestbp.2022.105213
van Rensburg JBJ (2007) First report of field resistance by the stem borer, busseola fusca (fuller) to bt-transgenic maize. South African J Plant Soil 24:147–151. https://doi.org/10.1080/02571862.2007.10634798
Vandenberghe LPS, Garcia LMB, Rodrigues C et al (2017) Potential applications of plant probiotic microorganisms in agriculture and forestry. AIMS Microbiol 3:629–648. https://doi.org/10.3934/microbiol.2017.3.629
Varejão EVV, Demuner AJ, Barbosa LCA, Barreto RW (2013) The search for new natural herbicides—strategic approaches for discovering fungal phytotoxins. Crop Prot 48:41–50. https://doi.org/10.1016/j.cropro.2013.02.008
Vesonder RF, Labeda DP, Peterson RE (1992) Phytotoxic activity of selected water-soluble metabolites of Fusarium against Lemna minor L. (Duckweed). Mycopathologia 118:185–189. https://doi.org/10.1007/BF00437153
Wakefield J, Hassan HM, Jaspars M et al (2017) Dual induction of new microbial secondary metabolites by fungal bacterial co-cultivation. Front Microbiol 1:1284. https://doi.org/10.3389/FMICB.2017.01284
Wang L, Li X, Zhang G et al (2007) Oil-in-water nanoemulsions for pesticide formulations. J Colloid Interface Sci 314:230–235. https://doi.org/10.1016/j.jcis.2007.04.079
Wang B, Kang Q, Lu Y et al (2012) Unveiling the biosynthetic puzzle of destruxins in Metarhizium species. PNAS 109:1287–1292. https://doi.org/10.1073/pnas.1115983109
Wang P, Lombi E, Zhao FJ, Kopittke PM (2016) Nanotechnology: a new opportunity in plant sciences. Trends Plant Sci 21:699–712. https://doi.org/10.1016/J.TPLANTS.2016.04.005
Wang ZR, Yang HX, Peng XP et al (2020) Induced production of zinniol analogues by co-cultivation of two endophytic fungi in the same ecological niche. Phytochem Lett 35:206–210. https://doi.org/10.1016/j.phytol.2019.12.007
Wang H, Peng H, Li W et al (2021a) The toxins of beauveria bassiana and the strategies to improve their virulence to insects. Front Microbiol 12:2375. https://doi.org/10.3389/FMICB.2021.705343/BIBTEX
Wang H, Peng H, Li W et al (2021b) The toxins of beauveria bassiana and the strategies to improve their virulence to insects. Front Microbiol 12:1–11. https://doi.org/10.3389/fmicb.2021.705343
Wang H, Zhang R, Duan Y et al (2021c) The endophytic strain trichoderma asperellum 6s–2: an efficient biocontrol agent against apple replant disease in china and a potential plant-growth-promoting fungus. J Fungi 7:2. https://doi.org/10.3390/jof7121050
Wang M, Geng L, Xue B et al (2021d) Structure characteristics and function of a novel extracellular polysaccharide from Bacillus thuringiensis strain 4D19. Int J Biol Macromol 189:956–964. https://doi.org/10.1016/j.ijbiomac.2021.08.193
Weikl F, Ghirardo A, Schnitzler J-P, Pritsch K (2016) Sesquiterpene emissions from Alternaria alternata and Fusarium oxysporum : effects of age, nutrient availability and co-cultivation. Sci Rep 6:1–12. https://doi.org/10.1038/SREP22152
Wolpert TJ, Dunkle LD, Ciuffetti LM (2002) Host-selective toxins and avirulence determinants: What’s in a name? Annu Rev Phytopathol 40:251–285
Wraight SP, Jackson MA, de Kokc SL (2009) Production, stabilization and formulation of fungal biocontrol agents. Fungi Biocontrol Agents Progr Probl Potential 2:253–287. https://doi.org/10.1079/9780851993560.0253
Wu Q, Ni M, Dou K et al (2018) Co-culture of Bacillus amyloliquefaciens ACCC11060 and Trichoderma asperellum GDFS1009 enhanced pathogen-inhibition and amino acid yield. Microb Cell Fact 17:1–12. https://doi.org/10.1186/s12934-018-1004-x
Xu D, Xue M, Shen Z et al (2021) Phytotoxic secondary metabolites from fungi. Toxins. https://doi.org/10.3390/toxins13040261
Yang J, Kloepper JW, Ryu CM (2009) Rhizosphere bacteria help plants tolerate abiotic stress. Trends Plant Sci 14:1–4. https://doi.org/10.1016/j.tplants.2008.10.004
Zhang L, Niaz SI, Khan D et al (2017) Induction of diverse bioactive secondary metabolites from the mangrove endophytic fungus Trichoderma sp. (Strain 307) by co-cultivation with acinetobacter johnsonii (Strain B2). Mar Drugs 15:35. https://doi.org/10.3390/MD15020035
Zhang Y, Chen Z, Sun P et al (2021) Effect of low-level ultrasound treatment on the production of L-leucine by Corynebacterium glutamicum in fed-batch culture. Bioengineered 12:1078–1090. https://doi.org/10.1080/21655979.2021.1906028
Zhu F, Lin Y (2006) Marinamide, a novel alkaloid and its methyl ester produced by the application of mixed fermentation technique to two mangrove endophytic fungi from the South China Sea. Chin Sci Bull 51:1426–1430. https://doi.org/10.1007/S11434-006-1426-4
Zhu F, Qin C, Tao L et al (2011) Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting. Proc Natl Acad Sci 108:12943–12948. https://doi.org/10.1073/PNAS.1107336108
Acknowledgements
The authors thank the National Council for Scientific and Technological Development (CNPq) for the funding (140128/2021-2).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare no commercial or financial conflict of interest.
Human participants and/or animals
The authors also inform that the research did not involve Human Participants and/or Animals.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Schmaltz, S., Silva, M.A., Ninaus, R.G. et al. Biomolecules in modern and sustainable agriculture. 3 Biotech 13, 70 (2023). https://doi.org/10.1007/s13205-023-03486-2
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s13205-023-03486-2