Skip to main content

Advertisement

SpringerLink
Log in

Report of clinical studies on chronochemotherapy for advanced non-small cell lung cancer in China

  • Research Article
  • Published:
Tumor Biology

Abstract

Chronochemotherapy has been proposed as a promising modality to provide timely optimized medication to achieve maximum efficacy with minimum side effect for patients with non-small cell lung cancer for years. We collected the data of 11 clinical studies performed in China with the purpose to compare the difference between chronochemotherapy and traditional chemotherapy. Results showed that chronochemotherapy has a more favorable efficacy and safety than traditional chemotherapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA. Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc. 2008;83:584–94.

    Article  Google Scholar 

  2. Brodowicz T, Krzakowski M, Zwitter M, Tzekova V, Ramlau R, Ghilezan N, et al. Cisplatin and gemcitabine first-line chemotherapy followed by maintenance gemcitabine or best supportive care in advanced non-small cell lung cancer: a phase iii trial. Lung Cancer. 2006;52:155–63.

    Article  Google Scholar 

  3. Cappuzzo F, Ciuleanu T, Stelmakh L, Cicenas S, Szczesna A, Juhasz E, et al. Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study. Lancet Oncol. 2010;11:521–9.

    Article  CAS  Google Scholar 

  4. Non small cell lung cancer. 2013, cited 2013-10-30. Available from: http://www.nccn.org/professionals/physician_gls/pdf/nscl.Pdf.

  5. Nation Comprehensive Cancer Network (2013) non–small cell lung cancer (version 2.2014). Available: http://www.nccn.org/professionals/physician_gls/pdf/nscl.Pdf Accessed 21 Jan 2014.

  6. Azzoli CG, Temin S, Giaccone G. 2011 focused update of 2009 American Society of Clinical Oncology clinical practice guideline update on chemotherapy for stage iv non-small-cell lung cancer. J Oncol Pract/Am Soc Clin Oncol. 2012;8:63–6.

    Article  Google Scholar 

  7. Azzoli CG, Giaccone G, Temin S. American Society of Clinical Oncology clinical practice guideline update on chemotherapy for stage iv non-small-cell lung cancer. J Oncol Pract/Am Soc Clin Oncol. 2010;6:39–43.

    Article  Google Scholar 

  8. D’Addario G, Felip E, Group EGW. Non-small-cell lung cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol: Off J Eur Soc Med Oncol/ESMO. 2009;20 Suppl 4:68–70.

    Article  Google Scholar 

  9. Bareschino MA, Schettino C, Rossi A, Maione P, Sacco PC, Zeppa R, et al. Treatment of advanced non small cell lung cancer. J Thorac Dis. 2011;3:122–33.

    PubMed  PubMed Central  Google Scholar 

  10. Sahar S, Sassone-Corsi P. Metabolism and cancer: the circadian clock connection. Nat Rev Cancer. 2009;9:886–96.

    Article  CAS  Google Scholar 

  11. Levi F, Okyar A, Dulong S, Innominato PF, Clairambault J. Circadian timing in cancer treatments. Annu Rev Pharmacol Toxicol. 2010;50:377–421.

    Article  CAS  Google Scholar 

  12. Levi F. Chronotherapeutics: the relevance of timing in cancer therapy. Cancer Causes Control: CCC. 2006;17:611–21.

    Article  Google Scholar 

  13. Halberg F, Haus E, Cardoso SS, Scheving LE, Kuhl JF, Shiotsuka R, et al. Toward a chronochemotherapy of neoplasia: tolerance of treatment depends upon host rhythms. Experientia. 1973;29:909–34.

    Article  CAS  Google Scholar 

  14. Mormont MC, Levi F. Circadian-system alterations during cancer processes: a review. International journal of cancer Journal international du cancer. 1997;70:241–7.

    Article  CAS  Google Scholar 

  15. Huang XL, Fu CJ, Bu RF. Role of circadian clocks in the development and therapeutics of cancer. J Int Med Res. 2011;39:2061–6.

    Article  CAS  Google Scholar 

  16. Takimoto CH. Chronomodulated chemotherapy for colorectal cancer: failing the test of time? Eur J Cancer. 2006;42:574–81.

    Article  Google Scholar 

  17. Mormont MC, Levi F. Cancer chronochemotherapy: principles, applications, and perspectives. Cancer. 2003;97:155–69.

    Article  CAS  Google Scholar 

  18. Levi F, Schibler U. Circadian rhythms: mechanisms and therapeutic implications. Annu Rev Pharmacol Toxicol. 2007;47:593–628.

    Article  CAS  Google Scholar 

  19. Levi FA, Zidani R, Vannetzel JM, Perpoint B, Focan C, Faggiuolo R, et al. Chronomodulated versus fixed-infusion-rate delivery of ambulatory chemotherapy with oxaliplatin, fluorouracil, and folinic acid (leucovorin) in patients with colorectal cancer metastases: a randomized multi-institutional trial. J Natl Cancer Inst. 1994;86:1608–17.

    Article  CAS  Google Scholar 

  20. Focan C, Denis B, Kreutz F, Focan-Henrard D, Levi F. Ambulatory chronochemotherapy with 5-fluorouracil, folinic acid, and carboplatin for advanced non-small cell lung cancer. A phase ii feasibility trial. J Infus Chemother. 1995;5:148–52.

    CAS  PubMed  Google Scholar 

  21. Vincenzi B, Santini D, La Cesa A, Tonini G. Cancer chronochemotherapy: principles, applications, and perspectives. Cancer. 2003;98:881–2. author reply 882–883.

    Article  Google Scholar 

Download references

Acknowledgments

This study was supported by a grant from the Jiangsu Health International Exchange Supporting Program (to Dr. Xiao-Dong Li).

Conflicts of interest

None

Author information

Authors and Affiliations

  1. Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou, China

    Mei Ji, Xiao-Dong Li, Wei-Qing Zhao, Li-Na Zhu & Chang-Ping Wu

  2. Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, USA

    Hanze Zhang

  3. Department of Radiation Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China

    Zhong-Hua Ning

  4. Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan

    Xiaofei Zhang

  5. Department of Pharmacy, The Third Affiliated Hospital of Soochow University, Changzhou, China

    Jie Li

  6. Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou, China

    Chang-Ping Wu

Authors
  1. Mei Ji
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiao-Dong Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hanze Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Zhong-Hua Ning
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Xiaofei Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Wei-Qing Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Li-Na Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jie Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Chang-Ping Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Mei Ji or Chang-Ping Wu.

Additional information

Mei Ji and Xiao-Dong Li are the co-first authors.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ji, M., Li, XD., Zhang, H. et al. Report of clinical studies on chronochemotherapy for advanced non-small cell lung cancer in China. Tumor Biol. 35, 12285–12292 (2014). https://doi.org/10.1007/s13277-014-2539-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13277-014-2539-z

Keywords

Search

Navigation