Abstract
Lung cancer remains a leading cause of cancer-associated mortality worldwide, and non-small lung cancer (NSCLC) is responsible for over 80 % of lung cancer-related deaths. Identifying novel molecular biomarker that can inhibit the progression of lung cancer will facilitate the development of new treatment strategies. Herein, we demonstrated that miR-541-3p is a tumor-suppressor microRNA (miRNA) in NSCLC progression. We found that expression of miR-541-3p was decreased obviously in NSCLC tissues and plasma. Down-regulation of miR-541-3p was associated with TNM stage and postoperative survival. Overexpression of miR-541-3p inhibited the growth and metastasis of NSCLC cells. The TGIF2 was a direct target of miR-541-3p and promoted the growth and metastasis of NSCLC cells. Further study showed that TGIF2 could reverse the inhibitory effect of miR-541-3p on growth and metastasis of NSCLC cells. Taken together, our data highlight the pivotal role of miR-541-3p in the progression of NSCLC. Thus, miR-541-3p may be a potential prognostic marker and of treatment relevance for NSCLC progression intervention.
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YJL and RYL conceived and designed the experiments. YJL, KH, and YW performed the experiments. YJL analyzed the data. YJL and KH contributed reagents/materials/analysis tools. YJL and RYL wrote the manuscript.
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Lu, YJ., Liu, RY., Hu, K. et al. MiR-541-3p reverses cancer progression by directly targeting TGIF2 in non-small cell lung cancer. Tumor Biol. 37, 12685–12695 (2016). https://doi.org/10.1007/s13277-016-5241-5
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DOI: https://doi.org/10.1007/s13277-016-5241-5