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Use of Cortical Stimulation in Neuropathic Pain, Tinnitus, Depression, and Movement Disorders

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Neurotherapeutics

Abstract

Medical treatment must strike a balance between benefit and risk. As the field of neuromodulation develops, decreased invasiveness, in combination with maintenance of efficacy, has become a goal. We provide a review of the history of cortical stimulation from its origins to the current state. The first part discusses neuropathic pain and the nonpharmacological treatment options used. The second part covers transitions to tinnitus, believed by many to be another deafferentation disorder, its classification, and treatment. The third part focuses on major depression. The fourth section concludes with the discussion of the use of cortical stimulation in movement disorders. Each part discusses the development of the field, describes the current care protocols, and suggests future avenues for research needed to advance neuromodulation.

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References

  1. Treister R, Lang M, Klein MM, Oaklander AL. Non-invasive transcranial magnetic stimulation (tms) of the motor cortex for neuropathic pain-at the tipping point? Rambam Maimonides Med J 2013;4:e0023.

    PubMed Central  PubMed  Google Scholar 

  2. Institute of Medicine. Relieving pain in America: a blueprint for transforming prevention, care, education, and research. Institute of Medicine, Washington DC, 2011.

  3. Tang NK, Crane C. Suicidality in chronic pain: a review of the prevalence, risk factors and psychological links. Psychol Med 2006;36:575-586.

    PubMed  Google Scholar 

  4. Smith BH, Elliott AM, Chambers WA, Smith WC, Hannaford PC, Penny K. The impact of chronic pain in the community. Fam Pract 2001;18:292-299.

    CAS  PubMed  Google Scholar 

  5. Whitaker HA, Smith CUM, Finger S. Brain, mind, and medicine: essays in eighteenth-century neuroscience. Springer, New York, 2007.

    Google Scholar 

  6. Schwalb JM, Hamani C. The history and future of deep brain stimulation. Neurotherapeutics 2008;5:3-13.

    PubMed  Google Scholar 

  7. Devinsky O. Electrical and magnetic stimulation of the central nervous system. Historical overview. Adv Neurol 1993;63:1-16.

    CAS  PubMed  Google Scholar 

  8. Hagner M. The electrical excitability of the brain: toward the emergence of an experiment. J Hist Neurosci 2012;21:237-249.

    PubMed  Google Scholar 

  9. Zago S, Ferrucci R, Fregni F, Priori A. Bartholow, Sciamanna, Alberti: pioneers in the electrical stimulation of the exposed human cerebral cortex. Neuroscientist 2008;14:521-528.

    PubMed  Google Scholar 

  10. Lazar RM, Mohr JP. Revisiting the contributions of Paul Broca to the study of aphasia. Neuropsychol Rev 2011;21:236-239.

    PubMed  Google Scholar 

  11. Fritsch G, Hitzig E. Electric excitability of the cerebrum (Uber die elektrische Erregbarkeit des Grosshirns). Epilepsy Behav 2009;15:123-130.

    CAS  PubMed  Google Scholar 

  12. Horsley V. Remarks on the surgery of the central nervous system. Br Med J 1890;2:1286-1292.

    CAS  PubMed Central  PubMed  Google Scholar 

  13. Ramey ER, O'Doherty DS. Electrical studies on the unanesthetized brain; a symposium with 49 participants. P. B. Hoeber, New York, 1960.

    Google Scholar 

  14. Ervin FR, Mark VH, Stevens J. Behavioral and affective responses to brain stimulation in man. Proc Annu Meet Am Psychopathol Assoc 1969;58:54-65.

    CAS  PubMed  Google Scholar 

  15. Gol A. Relief of pain by electrical stimulation of the septal area. J Neurol Sci 1967;5:115-120.

    CAS  PubMed  Google Scholar 

  16. Tsubokawa T, Katayama Y, Yamamoto T, Hirayama T. Deafferentation pain and stimulation of the thalamic sensory relay nucleus: clinical and experimental study. Appl Neurophysiol 1985;48:166-171.

    CAS  PubMed  Google Scholar 

  17. Tsubokawa T, Katayama Y, Yamamoto T, Hirayama T, Koyama S. Treatment of thalamic pain by chronic motor cortex stimulation. Pacing Clin Electrophysiol 1991;14:131-134.

    CAS  PubMed  Google Scholar 

  18. Tsubokawa T, Katayama Y, Yamamoto T, Hirayama T, Koyama S. Chronic motor cortex stimulation in patients with thalamic pain. J Neurosurg 1993;78:393-401.

    CAS  PubMed  Google Scholar 

  19. Meyerson BA, Lindblom U, Linderoth B, Lind G, Herregodts P. Motor cortex stimulation as treatment of trigeminal neuropathic pain. Acta Neurochir Suppl (Wien) 1993;58:150-153.

    CAS  Google Scholar 

  20. Katayama Y, Fukaya C, Yamamoto T. Poststroke pain control by chronic motor cortex stimulation: neurological characteristics predicting a favorable response. J Neurosurg 1998;89:585-591.

    CAS  PubMed  Google Scholar 

  21. Lima MC, Fregni F. Motor cortex stimulation for chronic pain: systematic review and meta-analysis of the literature. Neurology 2008;70:2329-2337.

    PubMed  Google Scholar 

  22. Nuti C, Peyron R, Garcia-Larrea L, et al. Motor cortex stimulation for refractory neuropathic pain: four year outcome and predictors of efficacy. Pain 2005;118:43-52.

    PubMed  Google Scholar 

  23. Irlbacher K, Kuhnert J, Roricht S, Meyer BU, Brandt SA. [Central and peripheral deafferent pain: therapy with repetitive transcranial magnetic stimulation]. Nervenarzt 2006;77:1196, 1198-1203 [in German].

    Google Scholar 

  24. Hirayama A, Saitoh Y, Kishima H, et al. Reduction of intractable deafferentation pain by navigation-guided repetitive transcranial magnetic stimulation of the primary motor cortex. Pain 2006;122:22-27.

    PubMed  Google Scholar 

  25. Wasserman E, Epstein CM, Ziemann U. The Oxford handbook of transcranial stimulation. Oxford University Press, Oxford, 2008.

  26. Gasquoine PG. Localization of function in anterior cingulate cortex: from psychosurgery to functional neuroimaging. Neurosci Biobehav Rev 2013;37:340-348.

    PubMed  Google Scholar 

  27. Maarrawi J, Peyron R, Mertens P, et al. Motor cortex stimulation for pain control induces changes in the endogenous opioid system. Neurology 2007;69:827-834.

    CAS  PubMed  Google Scholar 

  28. Cha M, Ji Y, Masri R. Motor cortex stimulation activates the incertothalamic pathway in an animal model of spinal cord injury. J Pain 2013;14:260-269.

    PubMed Central  PubMed  Google Scholar 

  29. Mhalla A, Baudic S, Ciampi de Andrade D, et al. Long-term maintenance of the analgesic effects of transcranial magnetic stimulation in fibromyalgia. Pain 2011;152:1478-1485.

    PubMed  Google Scholar 

  30. Canavero S, Bonicalzi V, Dotta M, Vighetti S, Asteggiano G, Cocito D. Transcranial magnetic cortical stimulation relieves central pain. Stereotact Funct Neurosurg 2002;78:192-196.

    CAS  PubMed  Google Scholar 

  31. Migita K, Uozumi T, Arita K, Monden S. Transcranial magnetic coil stimulation of motor cortex in patients with central pain. Neurosurgery 1995;36:1037-1039.

    CAS  PubMed  Google Scholar 

  32. Lefaucheur JP, Drouot X, Menard-Lefaucheur I, Nguyen JP. Neuropathic pain controlled for more than a year by monthly sessions of repetitive transcranial magnetic stimulation of the motor cortex. Neurophysiol Clin 2004;34:91-95.

    PubMed  Google Scholar 

  33. Henry JA, Dennis KC, Schechter MA. General review of tinnitus: prevalence, mechanisms, effects, and management. J Speech Lang Hear Res 2005;48:1204-1235.

    PubMed  Google Scholar 

  34. Ciocon JO, Amede F, Lechtenberg C, Astor F. Tinnitus: a stepwise workup to quiet the noise within. Geriatrics 1995;50:18-25.

    CAS  PubMed  Google Scholar 

  35. Hazell JW, McKinney CJ, Aleksy W. Mechanisms of tinnitus in profound deafness. Ann Otol Rhinol Laryngol Suppl 1995;166:418-420.

    CAS  PubMed  Google Scholar 

  36. Ramirez RR, Kopell BH, Butson CR, Gaggl W, Friedland DR, Baillet S. Neuromagnetic source imaging of abnormal spontaneous activity in tinnitus patient modulated by electrical cortical stimulation. Conf Proc IEEE Eng Med Biol Soc 2009;2009:1940-1944.

    PubMed  Google Scholar 

  37. Moller MB, Moller AR, Jannetta PJ, Jho HD. Vascular decompression surgery for severe tinnitus: selection criteria and results. Laryngoscope 1993;103:421-427.

    CAS  PubMed  Google Scholar 

  38. Robinson SK, Viirre ES, Stein MB. Antidepressant therapy in tinnitus. Hear Res 2007;226:221-231.

    CAS  PubMed  Google Scholar 

  39. Shailer MJ, Tyler RS, Coles RR. Critical masking bands for sensorineural tinnitus. Scand Audiol 1981;10:157-162.

    CAS  PubMed  Google Scholar 

  40. Zagolski O, Strek P. Tinnitus pitch and minimum masking levels in different etiologies. Int J Audiol 2014 Mar 31.

  41. Henry JA, Schechter MA, Zaugg TL, et al. Clinical trial to compare tinnitus masking and tinnitus retraining therapy. Acta Otolaryngol Suppl 2006 556:64-69.

    PubMed  Google Scholar 

  42. Bartels H, Staal MJ, Holm AF, Mooij JJ, Albers FW. Long-term evaluation of treatment of chronic, therapeutically refractory tinnitus by neurostimulation. Stereotact Funct Neurosurg 2007;85:150-157.

    CAS  PubMed  Google Scholar 

  43. De Ridder D, De Mulder G, Verstraeten E, et al. Primary and secondary auditory cortex stimulation for intractable tinnitus. ORL J Otorhinolaryngol Relat Spec 2006;68:48-54.

    PubMed  Google Scholar 

  44. Moller AR. Similarities between severe tinnitus and chronic pain. J Am Acad Audiol 2000;11:115-124.

    CAS  PubMed  Google Scholar 

  45. Hebert S, Fournier P, Norena A. The auditory sensitivity is increased in tinnitus ears. J Neurosci 2013;33:2356-2364.

    CAS  PubMed  Google Scholar 

  46. Kadner A, Viirre E, Wester DC, et al. Lateral inhibition in the auditory cortex: an EEG index of tinnitus? Neuroreport 2002;13:443-446.

    PubMed  Google Scholar 

  47. Ashton H, Reid K, Marsh R, Johnson I, Alter K, Griffiths T. High frequency localised “hot spots” in temporal lobes of patients with intractable tinnitus: a quantitative electroencephalographic (QEEG) study. Neurosci Lett 2007;426:23-28.

    CAS  PubMed  Google Scholar 

  48. Llinas RR, Ribary U, Jeanmonod D, Kronberg E, Mitra PP. Thalamocortical dysrhythmia: a neurological and neuropsychiatric syndrome characterized by magnetoencephalography. Proc Natl Acad Sci U S A 1999;96:15222-15227.

    CAS  PubMed Central  PubMed  Google Scholar 

  49. Eichhammer P, Langguth B, Marienhagen J, Kleinjung T, Hajak G. Neuronavigated repetitive transcranial magnetic stimulation in patients with tinnitus: a short case series. Biol Psychiatry 2003;54:862-865.

    PubMed  Google Scholar 

  50. De Ridder D, De Mulder G, Walsh V, Muggleton N, Sunaert S, Moller A. Magnetic and electrical stimulation of the auditory cortex for intractable tinnitus. Case report. J Neurosurg 2004;100:560-564.

    PubMed  Google Scholar 

  51. Fregni F, Marcondes R, Boggio PS, et al. Transient tinnitus suppression induced by repetitive transcranial magnetic stimulation and transcranial direct current stimulation. Eur J Neurol 2006;13:996-1001.

    CAS  PubMed  Google Scholar 

  52. Friedland DR, Gaggl W, Runge-Samuelson C, Ulmer JL, Kopell BH. Feasibility of auditory cortical stimulation for the treatment of tinnitus. Otol Neurotol 2007;28:1005-1012.

    PubMed  Google Scholar 

  53. Llinas R, Urbano FJ, Leznik E, Ramirez RR, van Marle HJ. Rhythmic and dysrhythmic thalamocortical dynamics: GABA systems and the edge effect. Trends Neurosci 2005;28:325-333.

    CAS  PubMed  Google Scholar 

  54. Jeanmonod D, Schulman J, Ramirez R, et al. Neuropsychiatric thalamocortical dysrhythmia: surgical implications. Neurosurg Clin N Am 2003;14:251-265.

    CAS  PubMed  Google Scholar 

  55. Anders M, Dvorakova J, Rathova L, et al. Efficacy of repetitive transcranial magnetic stimulation for the treatment of refractory chronic tinnitus: a randomized, placebo controlled study. Neuro Endocrinol Lett 2010;31:238-249.

    PubMed  Google Scholar 

  56. Marcondes RA, Sanchez TG, Kii MA, et al. Repetitive transcranial magnetic stimulation improve tinnitus in normal hearing patients: a double-blind controlled, clinical and neuroimaging outcome study. Eur J Neurol 2010;17:38-44.

    CAS  PubMed  Google Scholar 

  57. Burton H, Wineland A, Bhattacharya M, Nicklaus J, Garcia KS, Piccirillo JF. Altered networks in bothersome tinnitus: a functional connectivity study. BMC Neurosci 2012;13:3.

    PubMed Central  PubMed  Google Scholar 

  58. Maudoux A, Lefebvre P, Cabay JE, et al. Auditory resting-state network connectivity in tinnitus: a functional MRI study. PLoS One 2012;7:e36222.

    CAS  PubMed Central  PubMed  Google Scholar 

  59. Lehner A, Schecklmann M, Kreuzer PM, Poeppl TB, Rupprecht R, Langguth B. Comparing single-site with multisite rTMS for the treatment of chronic tinnitus - clinical effects and neuroscientific insights: study protocol for a randomized controlled trial. Trials 2013;14:269.

    PubMed Central  PubMed  Google Scholar 

  60. Park S, Park HJ, Kyeong SH, et al. Combined rTMS to the auditory cortex and prefrontal cortex for tinnitus control in patients with depression: a pilot study. Acta Otolaryngol 2013;133:600-606.

    PubMed  Google Scholar 

  61. Meng Z, Liu S, Zheng Y, Phillips JS. Repetitive transcranial magnetic stimulation for tinnitus. Cochrane Database Syst Rev 2011:CD007946.

  62. Fava M. Diagnosis and definition of treatment-resistant depression. Biol Psychiatry 2003;53:649-659.

    PubMed  Google Scholar 

  63. Carney RM, Freedland KE. Treatment-resistant depression and mortality after acute coronary syndrome. Am J Psychiatry 2009;166:410-417.

    PubMed Central  PubMed  Google Scholar 

  64. Crown WH, Finkelstein S, Berndt ER, et al. The impact of treatment-resistant depression on health care utilization and costs. J Clin Psychiatry 2002;63:963-971.

    PubMed  Google Scholar 

  65. Dunner DL, Rush AJ, Russell JM, et al. Prospective, long-term, multicenter study of the naturalistic outcomes of patients with treatment-resistant depression. J Clin Psychiatry 2006;67:688-695.

    PubMed  Google Scholar 

  66. Nemeroff CB. Prevalence and management of treatment-resistant depression. J Clin Psychiatry 2007;68(Suppl. 8):17-25.

    CAS  PubMed  Google Scholar 

  67. Leiknes KA, Jarosh-von Schweder L, Hoie B. Contemporary use and practice of electroconvulsive therapy worldwide. Brain Behav 2012;2:283-344.

    PubMed Central  PubMed  Google Scholar 

  68. Prudic J, Olfson M, Sackeim HA. Electro-convulsive therapy practices in the community. Psychol Med 2001;31:929-934.

    CAS  PubMed  Google Scholar 

  69. Kopell BH, Halverson J, Butson CR, et al. Epidural cortical stimulation of the left dorsolateral prefrontal cortex for refractory major depressive disorder. Neurosurgery 2011;69:1015-1029.

    PubMed  Google Scholar 

  70. Barker AT, Jalinous R, Freeston IL. Non-invasive magnetic stimulation of human motor cortex. Lancet 1985;1:1106-1107.

    CAS  PubMed  Google Scholar 

  71. Burt T, Lisanby SH, Sackeim HA. Neuropsychiatric applications of transcranial magnetic stimulation: a meta analysis. Int J Neuropsychopharmacol 2002;5:73-103.

    PubMed  Google Scholar 

  72. Gershon AA, Dannon PN, Grunhaus L. Transcranial magnetic stimulation in the treatment of depression. Am J Psychiatry 2003;160:835-845.

    PubMed  Google Scholar 

  73. Bermpohl F, Fregni F, Boggio PS, et al. Effect of low-frequency transcranial magnetic stimulation on an affective go/no-go task in patients with major depression: role of stimulation site and depression severity. Psychiatry Res 2006;141:1-13.

    PubMed  Google Scholar 

  74. O'Reardon JP, Solvason HB, Janicak PG, et al. Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. Biol Psychiatry 2007;62:1208-1216.

    PubMed  Google Scholar 

  75. George MS, Lisanby SH, Avery D, et al. Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham-controlled randomized trial. Arch Gen Psychiatry 2010;67:507-516.

    PubMed  Google Scholar 

  76. Schutter DJ. Antidepressant efficacy of high-frequency transcranial magnetic stimulation over the left dorsolateral prefrontal cortex in double-blind sham-controlled designs: a meta-analysis. Psychol Med 2009;39:65-75.

    CAS  PubMed  Google Scholar 

  77. George MS, Belmaker RH. Transcranial magnetic stimulation in neuropsychiatry. 1st ed. American Psychiatric Press, Washington, DC, 2000.

    Google Scholar 

  78. Mayberg HS, Lozano AM, Voon V, et al. Deep brain stimulation for treatment-resistant depression. Neuron 2005;45:651-660.

    CAS  PubMed  Google Scholar 

  79. Pascual-Leone A, Rubio B, Pallardo F, Catala MD. Rapid-rate transcranial magnetic stimulation of left dorsolateral prefrontal cortex in drug-resistant depression. Lancet 1996;348:233-237.

    CAS  PubMed  Google Scholar 

  80. Nahas Z, Anderson BS, Borckardt J, et al. Bilateral epidural prefrontal cortical stimulation for treatment-resistant depression. Biol Psychiatry 2010;67:101-109.

    PubMed Central  PubMed  Google Scholar 

  81. Olanow CW, Watts RL, Koller WC. An algorithm (decision tree) for the management of Parkinson’s disease (2001): treatment guidelines. Neurology 2001;56(11 Suppl. 5):S1-S88.

    CAS  PubMed  Google Scholar 

  82. Parkinson J. An essay on the shaking palsy. 1817. J Neuropsychiatry Clin Neurosci 2002;14:223-236.

    PubMed  Google Scholar 

  83. Patrick HT, Levy DM. Parkinson’s disease: a clinical study of one hundred and forty-six cases. Arch Neurol Psychiatry 1922;7:711-720.

    Google Scholar 

  84. Bucy PC, Case TJ. Tremor: physiologic mechanism and abolition by surgical means. Arch Neurol Psychiatry 1939;41:721-746.

    Google Scholar 

  85. Walker AE. Cerebral pedunculotomy for the relief of involuntary movements. II. Parkinsonian tremor. J Nerv Ment Dis 1952;116:766-775.

    CAS  PubMed  Google Scholar 

  86. Canavero S, Paolotti R. Extradural motor cortex stimulation for advanced Parkinson’s disease: case report. Mov Disord 2000;15:169-171.

    CAS  PubMed  Google Scholar 

  87. Katayama Y, Oshima H, Fukaya C, Kawamata T, Yamamaoto T. Control of post-stroke movement disorders using chronic motor cortex stimulation. Acta Neurochir Suppl 2002;79:89-92.

    CAS  PubMed  Google Scholar 

  88. Pagni CA, Altibrandi MG, Bentivoglio A, et al. Extradural motor cortex stimulation (EMCS) for Parkinson’s disease. History and first results by the study group of the Italian neurosurgical society. Acta Neurochir Suppl 2005;93:113-119.

    CAS  PubMed  Google Scholar 

  89. Franzini A, Ferroli P, Dones I, Marras C, Broggi G. Chronic motor cortex stimulation for movement disorders: a promising perspective. Neurol Res 2003;25:123-126.

    PubMed  Google Scholar 

  90. Nguyen JP, Pollin B, Feve A, Geny C, Cesaro P. Improvement of action tremor by chronic cortical stimulation. Mov Disord 1998;13:84-88.

    CAS  PubMed  Google Scholar 

  91. Haslinger B, Erhard P, Kampfe N, et al. Event-related functional magnetic resonance imaging in Parkinson’s disease before and after levodopa. Brain 2001;124:558-570.

    CAS  PubMed  Google Scholar 

  92. Sabatini U, Boulanouar K, Fabre N, et al. Cortical motor reorganization in akinetic patients with Parkinson’s disease: a functional MRI study. Brain 2000;123:394-403.

    PubMed  Google Scholar 

  93. Bostantjopoulou S, Katsarou Z, Zafiriou D, et al. Abnormality of N30 somatosensory evoked potentials in Parkinson’s disease: a multidisciplinary approach. Neurophysiol Clin 2000;30:368-376.

    CAS  PubMed  Google Scholar 

  94. Rossini PM, Babiloni F, Bernardi G, et al. Abnormalities of short-latency somatosensory evoked potentials in parkinsonian patients. Electroencephalogr Clin Neurophysiol 1989;74:277-289.

    CAS  PubMed  Google Scholar 

  95. Jahanshahi M, Jenkins IH, Brown RG, Marsden CD, Passingham RE, Brooks DJ. Self-initiated versus externally triggered movements. I. An investigation using measurement of regional cerebral blood flow with PET and movement-related potentials in normal and Parkinson’s disease subjects. Brain 1995;118:913-933.

    PubMed  Google Scholar 

  96. Playford ED, Jenkins IH, Passingham RE, Nutt J, Frackowiak RS, Brooks DJ. Impaired mesial frontal and putamen activation in Parkinson’s disease: a positron emission tomography study. Ann Neurol 1992;32:151-161.

    CAS  PubMed  Google Scholar 

  97. Eidelberg D, Moeller JR, Ishikawa T, et al. The metabolic topography of idiopathic torsion dystonia. Brain 1995;118 :1473-1484.

    PubMed  Google Scholar 

  98. Buhmann C, Glauche V, Sturenburg HJ, Oechsner M, Weiller C, Buchel C. Pharmacologically modulated fMRI—cortical responsiveness to levodopa in drug-naive hemiparkinsonian patients. Brain 2003;126:451-461.

    CAS  PubMed  Google Scholar 

  99. Boylan LS, Pullman SL, Lisanby SH, Spicknall KE, Sackeim HA. Repetitive transcranial magnetic stimulation to SMA worsens complex movements in Parkinson’s disease. Clin Neurophysiol 2001;112:259-264.

    CAS  PubMed  Google Scholar 

  100. Khedr EM, Farweez HM, Islam H. Therapeutic effect of repetitive transcranial magnetic stimulation on motor function in Parkinson’s disease patients. Eur J Neurol 2003;10:567-572.

    CAS  PubMed  Google Scholar 

  101. Fregni F, Simon DK, Wu A, Pascual-Leone A. Non-invasive brain stimulation for Parkinson’s disease: a systematic review and meta-analysis of the literature. J Neurol Neurosurg Psychiatry 2005;76:1614-1623.

    CAS  PubMed Central  PubMed  Google Scholar 

  102. Elahi B, Elahi B, Chen R. Effect of transcranial magnetic stimulation on Parkinson motor function–systematic review of controlled clinical trials. Mov Disord 2009;24:357-363.

    PubMed  Google Scholar 

  103. Chen R, Classen J, Gerloff C, et al. Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation. Neurology 1997;48:1398-1403.

    CAS  PubMed  Google Scholar 

  104. Speer AM, Kimbrell TA, Wassermann EM, et al. Opposite effects of high and low frequency rTMS on regional brain activity in depressed patients. Biol Psychiatry 2000;48:1133-1141.

    CAS  PubMed  Google Scholar 

  105. Shirota Y, Ohtsu H, Hamada M, Enomoto H, Ugawa Y, Research Committee on rTMS Treatment of Parkinson’s Disease. Supplementary motor area stimulation for Parkinson disease: a randomized controlled study. Neurology 2013;80:1400-1405.

    PubMed  Google Scholar 

  106. Canavero S, Bonicalzi V, Paolotti R, et al. Therapeutic extradural cortical stimulation for movement disorders: a review. Neurol Res 2003;25:118-122.

    PubMed  Google Scholar 

  107. Kleiner-Fisman G, Fisman DN, Kahn FI, Sime E, Lozano AM, Lang AE. Motor cortical stimulation for parkinsonism in multiple system atrophy. Arch Neurol 2003;60:1554-1558.

    PubMed  Google Scholar 

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  1. Department of Neurosurgery, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY, 10029, USA

    Fedor Panov & Brian Harris Kopell

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Panov, F., Kopell, B.H. Use of Cortical Stimulation in Neuropathic Pain, Tinnitus, Depression, and Movement Disorders. Neurotherapeutics 11, 564–571 (2014). https://doi.org/10.1007/s13311-014-0283-0

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