Abstract
Objective
To evaluate the differential characteristics of SARS-COV-2 associated inflammatory multisystem syndrome (MIS-C) in children.
Methods
A retrospective cohort study was conducted. The definition of MIS-C was based on WHO criteria. Temporally related COVID-19 patients were included as controls.
Results
25 patients with MIS-C and 75 controls were included. Multivariate multiple logistic regression model of variables that showed to be significant in univariate analysis revealed that age ≥2 years (OR 24.7; 95% CI 1.03–592.4; P=0.048), lymphopenia (OR 9.03, 95%CI 2.05–39.7; P=0.004), and platelet count <150×109/L (OR 11.7; 95% CI 1.88–75.22; P=0.009) were significantly associated with MIS-C. Presence of underlying disease seemed to reduce the risk of MIS-C (OR 0.06; 95% CI 0.01–0.3).
Conclusion
MIS-C was more common in patients older than 2 years and in those with lymphopenia or thrombocytopenia. Underlying disease appears to reduce the risk of MIS-C.
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Hospital Juan P Garrahan; No. 1294, dated October 11, 2020.
Contributors
MTR: conceptualized the study design; analyzed and interpreted the results, and wrote the manuscript; GP, MMK, AAP, MP, CG, NB, AB: recruited patients, collected demographic and clinical data analyzed and interpreted the results; RL,RB: conceptualized the study design- analyzed and interpreted the results, and commented on and revised the manuscript. All authors approved the final version of manuscript, and are accountable for all aspects related to the study.
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Rosanova, M.T., Perez, G., Katsicas, M.M. et al. Pediatric Inflammatory Multisystem Syndrome Associated With SARS-CoV-2: A Retrospective Cohort Study From Argentina. Indian Pediatr 58, 639–642 (2021). https://doi.org/10.1007/s13312-021-2259-6
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DOI: https://doi.org/10.1007/s13312-021-2259-6