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Prevalence of human Herpesviridae in cerebrospinal fluid of patients with multiple sclerosis and noninfectious neurological disease in the Netherlands

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Abstract

Prevalence of eight human herpesviruses (HHV1–8) was determined by real-time PCR in cell-rich cerebrospinal fluid (CSF) samples, obtained early after disease symptoms, of Dutch patients with multiple sclerosis (MS) and other noninfectious central nervous system diseases (NIND). Whereas HHV1–8 DNA was undetectable in CSF samples of MS patients, HHV6 DNA was detected in a plexus neuritis case and HHV7 DNA in an ependymoma and a Behçets’ disease patient. However, intrathecal HHV infection was not detected. Data indicate that HHV1–8 are rarely detected in CSF of Dutch NIND patients and do not support the role of intrathecal HHV infection early after onset of disease symptoms in MS.

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Acknowledgments

We thank the clinical staff from the Department of Neurology (Erasmus MC), especially Mrs. Kim van Gasteren and Kim Zuidwijk, for the collection and management of clinical samples.

Funding

The study was in part funded by the Dutch MS Research Foundation (project #09-670 MS). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Conflict of interest

The authors declare that no competing interests exist.

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Authors and Affiliations

  1. Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands

    Gijsbert P. van Nierop & Rogier Q. Hintzen

  2. Department of Viroscience, Erasmus University Medical Center, (Room Ee1720a), ‘s-Gravendijkwal 230 Erasmus MC, 3015 CE, Rotterdam, The Netherlands

    Gijsbert P. van Nierop & Georges M. G. M. Verjans

Authors
  1. Gijsbert P. van Nierop
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  2. Rogier Q. Hintzen
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  3. Georges M. G. M. Verjans
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Corresponding author

Correspondence to Georges M. G. M. Verjans.

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van Nierop, G.P., Hintzen, R.Q. & Verjans, G.M.G.M. Prevalence of human Herpesviridae in cerebrospinal fluid of patients with multiple sclerosis and noninfectious neurological disease in the Netherlands. J. Neurovirol. 20, 412–418 (2014). https://doi.org/10.1007/s13365-014-0248-4

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