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Association of Helicobacter pylori infection with metabolic and inflammatory profile in type 2 diabetes mellitus

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International Journal of Diabetes in Developing Countries Aims and scope Submit manuscript

Abstract

Objective

To evaluate the effect of Helicobacter pylori (H. pylori) infection upon metabolic and inflammatory parameters in type 2 diabetes mellitus (T2DM).

Methods

A total of 72 patients with T2DM were included in the study. These patients were divided into two groups as H. pylori infection positive or negative. For each patient, the following data were collected: age, gender, duration of diabetics, anti-diabetic treatment, the body mass index (BMI), and laboratory parameters (lipid profile, GLU, HbA1c, HCY, HsCRP, ghrelin, leptin, leukocyte, and platelet counts).

Results

Totally 47 patients (65.28%) were H. pylori positive and 25 patients (34.72%) were H. pylori negative. Diabetic patients infected by H. pylori showed significantly increased Lpa (297.83 ± 299.51 vs 154.24 ± 83.63, p < 0.05), higher HbA1c (9.21 ± 2.15 vs 8.00 ± 1.77, p < 0.05), and decreased leptin (4.59 ± 7.55 vs 9.82 ± 10.76, p < 0.05) than non-infected patients. Additionally, 72.2% of the patients with HbA1c > 7% were found to be H. pylori positive and 44.4% of the patients with HbA1c ≤ 7% were H. pylori positive. The levels of other parameters were not significantly different between two groups (p > 0.05), although CRP levels determined by high-sensitivity assay showed mild and variable increases in H. pylori infection.

Conclusion

H. pylori affects glycemic control in T2DM and might promote the development of diabetes.

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Acknowledgements

This study was supported by the Scientific Research Innovation Team Project of Anhui Colleges and Universities (2016-40), the University Natural Science Project of Anhui Province (KJ2017A229), the Project of Anhui province university outstanding youth talent support program (gxyq2018037), and the Science and technology development fund project of Bengbu medical college (BYKF1709).

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Author notes

  1. Jin Qili

    Present address: Department of Clinical Laboratory, The Second Affiliated Hospital of Bengbu Medical College, Bengbu, 233040, Anhui, People’s Republic of China

  2. Wei Li and Mohsin Raza Kashif contributed equally to this work.

Authors and Affiliations

  1. Anhui Provincial Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, 233030, Anhui, People’s Republic of China

    Wei Li, Mohsin Raza Kashif, Xia Hui & Jin Qili

  2. Department of Microbiology and Parasitology, Bengbu Medical College, Bengbu, 233030, Anhui, People’s Republic of China

    Wei Li, Mohsin Raza Kashif & Xia Hui

  3. Department of Clinical Laboratory, The Second Affiliated Hospital of Bengbu Medical College, Bengbu, 233040, Anhui, People’s Republic of China

    Yang Yuping & Chen Xia

Authors
  1. Wei Li
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  2. Mohsin Raza Kashif
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Correspondence to Wei Li or Jin Qili.

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Ethical approval

Our research protocol was approved by ethical committee of Bengbu Medical College, and a written informed consent was signed by each participant according to national and institutional guidelines.

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Li, W., Kashif, M.R., Yuping, Y. et al. Association of Helicobacter pylori infection with metabolic and inflammatory profile in type 2 diabetes mellitus. Int J Diabetes Dev Ctries 40, 47–51 (2020). https://doi.org/10.1007/s13410-019-00757-8

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  • DOI: https://doi.org/10.1007/s13410-019-00757-8

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