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Synergistic laxative effect of fermented rice extracts with probiotic-containing yogurt in normal rats

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Abstract

It was evaluated the synergistic effects of fermented rice extracts (FRe) on the laxative and probiotic effects of yogurt in normal rats. Commercial liquid yogurt (Bulgaris™) containing 0.05%, 0.10%, and 1.0% FRe (BFRe) was administered orally to normal rats daily for 10 days. Compared with the vehicle control, the three BFRe treatments exhibited highly significant increases in fecal pellet numbers, water content, thickness of surface mucous in the colonic lumen, intestinal charcoal transit ratio, thickness of the colonic mucosa, and mucous-producing goblet cells; decreased numbers and mean diameters of fecal pellets remaining in the colonic lumen were detected compared with the vehicle control, and numbers of viable Lactobacilli in cecum contents and feces were dramatically higher than those in vehicle control rats. More favorable probiotic and laxative effects were detected in rats treated with 0.1% and 1.0% BFRe compared with equal doses of liquid yogurt or FRe alone. Therefore, appropriate concentrations of BFRe may be highly effective for alleviating constipation and provide a complementary natural approach to reducing lifestyleinduced constipation.

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Authors and Affiliations

  1. JKnutra, #502, 17, Joongdaero 23-gil, Songpa-gu, Seoul, Korea

    Jong-Kwang Lee

  2. Glucan corp. #305 Marine Bio-Industry Development Center, Hoenggye-ri 27, Ilgwang-myeon, Gijan-gun, Busan, 619-912, Korea

    Joo Wan Kim & Ki-Young Kim

  3. RIS Center, IACF, Silla University, 140 Baegyang-daero 700beon-gil, Sasang-gu, Busan, 617-736, Korea

    Yu-Mi Ha, Jae Hak Sohn & Jae-Suk Choi

  4. Department of Bio-Food Materials, Silla University, Sasang-gu, Busan, 617-736, Korea

    Jae Hak Sohn & Jae-Suk Choi

  5. Department of Anatomy and Histology, College of Oriental Medicine, Daegu Haany University, Gyeongsan, 712-715, Korea

    Sae-Kwang Ku

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  1. Jong-Kwang Lee
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Correspondence to Sae-Kwang Ku or Jae-Suk Choi.

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Lee, JK., Kim, J.W., Kim, KY. et al. Synergistic laxative effect of fermented rice extracts with probiotic-containing yogurt in normal rats. Toxicol. Environ. Health Sci. 6, 87–98 (2014). https://doi.org/10.1007/s13530-014-0192-y

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  • DOI: https://doi.org/10.1007/s13530-014-0192-y

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