Skip to main content
Log in

Surgical Treatment of Fibroids

  • Management of Uterine Fibroid (I Meinhold-Heerlein, Section Editor)
  • Published:
Current Obstetrics and Gynecology Reports Aims and scope Submit manuscript

Abstract

Uterine leiomyomas are the most common benign tumors of the female genital tract. Fibroids are associated with a variety of clinical problems, including bleeding disorders, bulk-related symptoms, and infertility. For women who wish to preserve their uterus, fibroids can be surgically removed by hysteroscopy, laparoscopy, or laparotomy. The only definitive solution, however, is hysterectomy. The choice of treatment must be made after carefully weighing alternative treatment methods, such as expectant management, medical treatment, and interventional radiology, and obtaining informed consent. The optimal treatment decision takes into account the interests and wishes of the patient as well as the practical feasibility in the clinical setup. Surgical skills and experience are an important factor, as surgical procedures on the uterus are not without risk, and can lead to severe complications. The decision to operate anticipates an improvement of the initial situation, and the appropriate surgical approach is of the utmost importance.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Buttram Jr VC, Reiter RC. Uterine leiomyomata: etiology, symptomatology, and management. Fertil Steril. 1981;36(4):433–45.

    PubMed  Google Scholar 

  2. Lefebvre G, Vilos G, Allaire C, Jeffrey J, Arneja J, Birch C, et al. The management of uterine leiomyomas. J Obstet Gynaecol Can. 2003;25(5):396–418. quiz 9–22.

    PubMed  Google Scholar 

  3. Alkatout I, Mundhenke C, Maass N, Schem C. Die Rolle der Angiogenese und seiner Inhibitoren in der Gynäkologie. Der Gynäkologe. 2012. (in press).

  4. Peddada SD, Laughlin SK, Miner K, Guyon JP, Haneke K, Vahdat HL, et al. Growth of uterine leiomyomata among premenopausal black and white women. Proc Natl Acad Sci U S A. 2008;105(50):19887–92. doi:10.1073/pnas.0808188105.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  5. Laughlin SK, Hartmann KE, Baird DD. Postpartum factors and natural fibroid regression. Am J Obstet Gynecol. 2011;204(6):496 e1–6. doi:10.1016/j.ajog.2011.02.018.

    Article  Google Scholar 

  6. Zaima A, Ash A. Fibroid in pregnancy: characteristics, complications, and management. Postgrad Med J. 2011;87(1034):819–28. doi:10.1136/postgradmedj-2011-130319.

    Article  PubMed  Google Scholar 

  7. Marjoribanks J, Lethaby A, Farquhar C. Surgery versus medical therapy for heavy menstrual bleeding. Cochrane Database Syst Rev. 2006;2, CD003855. doi:10.1002/14651858.CD003855.pub2.

    PubMed  Google Scholar 

  8. Al-Hendy A, Lee EJ, Wang HQ, Copland JA. Gene therapy of uterine leiomyomas: adenovirus-mediated expression of dominant negative estrogen receptor inhibits tumor growth in nude mice. Am J Obstet Gynecol. 2004;191(5):1621–31. doi:10.1016/j.ajog.2004.04.022.

    Article  CAS  PubMed  Google Scholar 

  9. Edwards RD, Moss JG, Lumsden MA, Wu O, Murray LS, Twaddle S, et al. Uterine-artery embolization versus surgery for symptomatic uterine fibroids. N Engl J Med. 2007;356(4):360–70. doi:10.1056/NEJMoa062003.

    Article  CAS  PubMed  Google Scholar 

  10. van der Kooij SM, Bipat S, Hehenkamp WJ, Ankum WM, Reekers JA. Uterine artery embolization versus surgery in the treatment of symptomatic fibroids: a systematic review and metaanalysis. Am J Obstet Gynecol. 2011;205(4):17 e1–18. doi:10.1016/j.ajog.2011.03.016.

    Google Scholar 

  11. Kim HS, Baik JH, Pham LD, Jacobs MA. MR-guided high-intensity focused ultrasound treatment for symptomatic uterine leiomyomata: long-term outcomes. Acad Radiol. 2011;18(8):970–6. doi:10.1016/j.acra.2011.03.008.

    Article  PubMed Central  PubMed  Google Scholar 

  12. Funaki K, Fukunishi H, Sawada K. Clinical outcomes of magnetic resonance-guided focused ultrasound surgery for uterine myomas: 24-month follow-up. Ultrasound Obstet Gynecol. 2009;34(5):584–9. doi:10.1002/uog.7455.

    Article  CAS  PubMed  Google Scholar 

  13. Gynaecologists RCoOa. Preventing entry-related gynaecological laparoscopic injuries. RCOG Green-top Guideline. 2008;No.49:1–10.

  14. Wallach EE, Vlahos NF. Uterine myomas: an overview of development, clinical features, and management. Obstet Gynecol. 2004;104(2):393–406. doi:10.1097/01.aog.0000136079.62513.39.

    Article  PubMed  Google Scholar 

  15. Kim MS, Uhm YK, Kim JY, Jee BC, Kim YB. Obstetric outcomes after uterine myomectomy: laparoscopic versus laparotomic approach. Obstet Gynecol Sci. 2013;56(6):375–81. doi:10.5468/ogs.2013.56.6.375.

    Article  PubMed Central  PubMed  Google Scholar 

  16. Lonnerfors C, Persson J. Pregnancy following robot-assisted laparoscopic myomectomy in women with deep intramural myomas. Acta Obstet Gynecol Scand. 2011;90(9):972–7. doi:10.1111/j.1600-0412.2011.01207.x.

    Article  PubMed  Google Scholar 

  17. Mettler L, Schollmeyer T, Tinelli A, Malvasi A, Alkatout I. Complications of uterine fibroids and their management, surgical management of fibroids, laparoscopy and hysteroscopy versus hysterectomy, haemorrhage, adhesions, and complications. Obstet Gynecol Int. 2012;2012:791248. doi:10.1155/2012/791248.

    PubMed Central  PubMed  Google Scholar 

  18. Di Spiezio Sardo A, Mazzon I, Bramante S, Bettocchi S, Bifulco G, Guida M, et al. Hysteroscopic myomectomy: a comprehensive review of surgical techniques. Hum Reprod Update. 2008;14(2):101–19. doi:10.1093/humupd/dmm041.

    Article  PubMed  Google Scholar 

  19. Emanuel MH, Hart A, Wamsteker K, Lammes F. An analysis of fluid loss during transcervical resection of submucous myomas. Fertil Steril. 1997;68(5):881–6.

    Article  CAS  PubMed  Google Scholar 

  20. Wamsteker K, Emanuel MH, de Kruif JH. Transcervical hysteroscopic resection of submucous fibroids for abnormal uterine bleeding: results regarding the degree of intramural extension. Obstet Gynecol. 1993;82(5):736–40.

    CAS  PubMed  Google Scholar 

  21. Hart R, Molnar BG, Magos A. Long term follow up of hysteroscopic myomectomy assessed by survival analysis. Br J Obstet Gynaecol. 1999;106(7):700–5.

    Article  CAS  PubMed  Google Scholar 

  22. Mettler L, Sammur W, Alkatout I, Schollmeyer T. Imaging in gynecologic surgery. Womens Health (Lond Engl). 2011;7(2):239–48. doi:10.2217/whe.11.6. quiz 49–50.

    Article  Google Scholar 

  23. Varma R, Soneja H, Clark TJ, Gupta JK. Hysteroscopic myomectomy for menorrhagia using Versascope bipolar system: efficacy and prognostic factors at a minimum of one year follow up. Eur J Obstet Gynecol Reprod Biol. 2009;142(2):154–9. doi:10.1016/j.ejogrb.2008.10.006.

    Article  PubMed  Google Scholar 

  24. Loffer FD, Bradley LD, Brill AI, Brooks PG, Cooper JM. Hysteroscopic fluid monitoring guidelines. J Am Assoc Gynecol Laparosc. 2000;7(3):438.

    Article  PubMed  Google Scholar 

  25. Jansen FW, Vredevoogd CB, van Ulzen K, Hermans J, Trimbos JB, Trimbos-Kemper TC. Complications of hysteroscopy: a prospective, multicenter study. Obstet Gynecol. 2000;96(2):266–70.

    Article  CAS  PubMed  Google Scholar 

  26. Propst AM, Liberman RF, Harlow BL, Ginsburg ES. Complications of hysteroscopic surgery: predicting patients at risk. Obstet Gynecol. 2000;96(4):517–20.

    Article  CAS  PubMed  Google Scholar 

  27. Parker WH, Rodi IA. Patient selection for laparoscopic myomectomy. J Am Assoc Gynecol Laparosc. 1994;2(1):23–6.

    Article  CAS  PubMed  Google Scholar 

  28. Alkatout I, Bojahr B, Dittmann L, Warneke V, Mettler L, Jonat W, et al. Precarious preoperative diagnostics and hints for the laparoscopic excision of uterine adenomatoid tumors: two exemplary cases and literature review. Fertil Steril. 2010;95(3):1119 e5–8. doi:10.1016/j.fertnstert.2010.10.017.

    Google Scholar 

  29. Dueholm M, Lundorf E, Hansen ES, Ledertoug S, Olesen F. Accuracy of magnetic resonance imaging and transvaginal ultrasonography in the diagnosis, mapping, and measurement of uterine myomas. Am J Obstet Gynecol. 2002;186(3):409–15.

    Article  PubMed  Google Scholar 

  30. Alkatout I, Honemeyer U, Strauss A, Tinelli A, Malvasi A, Jonat W, et al. Clinical diagnosis and treatment of ectopic pregnancy. Obstet Gynecol Surv. 2013;68(8):571–81. doi:10.1097/OGX.0b013e31829cdbeb.

    Article  PubMed  Google Scholar 

  31. Alkatout I, Schollmeyer T, Hawaldar NA, Sharma N, Mettler L. Principles and safety measures of electrosurgery in laparoscopy. JSLS. 2012;16(1):130–9. doi:10.4293/108680812X13291597716348.

    Article  PubMed Central  PubMed  Google Scholar 

  32. Alkatout I, Stuhlmann-Laeisz C, Mettler L, Jonat W, Schollmeyer T. Organ-preserving management of ovarian pregnancies by laparoscopic approach. Fertil Steril. 2011;95(8):2467–70 e1-2. doi:10.1016/j.fertnstert.2010.12.060.

  33. Kongnyuy EJ, Wiysonge CS. Interventions to reduce haemorrhage during myomectomy for fibroids. Cochrane Database Syst Rev. 2011;11, CD005355. doi:10.1002/14651858.CD005355.pub4.

    PubMed  Google Scholar 

  34. Zhao F, Jiao Y, Guo Z, Hou R, Wang M. Evaluation of loop ligation of larger myoma pseudocapsule combined with vasopressin on laparoscopic myomectomy. Fertil Steril. 2010;95(2):762–6. doi:10.1016/j.fertnstert.2010.08.059.

    Article  Google Scholar 

  35. Tinelli A, Mettler L, Malvasi A, Hurst B, Catherino W, Mynbaev OA, et al. Impact of surgical approach on blood loss during intracapsular myomectomy. Minim Invasive Ther Allied Technol. 2013. doi:10.3109/13645706.2013.839951.

    PubMed  Google Scholar 

  36. Celik H, Sapmaz E. Use of a single preoperative dose of misoprostol is efficacious for patients who undergo abdominal myomectomy. Fertil Steril. 2003;79(5):1207–10.

    Article  PubMed  Google Scholar 

  37. Mettler L, Sammur W, Schollmeyer T, Alkatout I. Cross-linked sodium hyaluronate, an anti-adhesion barrier gel in gynaecological endoscopic surgery. Minim Invasive Ther Allied Technol. 2013;22(5):260–5. doi:10.3109/13645706.2012.751034.

    Article  PubMed  Google Scholar 

  38. Mettler L, Schollmeyer T, Alkatout I. Adhesions during and after surgical procedures, their prevention and impact on women's health. Womens Health (Lond Engl). 2012;8(5):495–8. doi:10.2217/whe.12.34.

    Article  CAS  Google Scholar 

  39. Tulandi T, Murray C, Guralnick M. Adhesion formation and reproductive outcome after myomectomy and second-look laparoscopy. Obstet Gynecol. 1993;82(2):213–5.

    CAS  PubMed  Google Scholar 

  40. Tsuji S, Takahashi K, Imaoka I, Sugimura K, Miyazaki K, Noda Y. MRI evaluation of the uterine structure after myomectomy. Gynecol Obstet Invest. 2006;61(2):106–10. doi:10.1159/000089144.

    Article  PubMed  Google Scholar 

  41. D'Angelo E, Prat J. Uterine sarcomas: a review. Gynecol Oncol. 2009;116(1):131–9. doi:10.1016/j.ygyno.2009.09.023.

    Article  PubMed  Google Scholar 

  42. Mukhopadhaya N, De Silva C, Manyonda IT. Conventional myomectomy. Best Pract Res Clin Obstet Gynaecol. 2008;22(4):677–705. doi:10.1016/j.bpobgyn.2008.01.012.

    Article  PubMed  Google Scholar 

  43. Discepola F, Valenti DA, Reinhold C, Tulandi T. Analysis of arterial blood vessels surrounding the myoma: relevance to myomectomy. Obstet Gynecol. 2007;110(6):1301–3. doi:10.1097/01.AOG.0000290331.95709.26.

    Article  PubMed  Google Scholar 

  44. Pundir J, Pundir V, Walavalkar R, Omanwa K, Lancaster G, Kayani S. Robotic-assisted laparoscopic vs abdominal and laparoscopic myomectomy: systematic review and meta-analysis. J Minim Invasive Gynecol. 2013;20(3):335–45. doi:10.1016/j.jmig.2012.12.010.

    Article  PubMed  Google Scholar 

  45. Barakat EE, Bedaiwy MA, Zimberg S, Nutter B, Nosseir M, Falcone T. Robotic-assisted, laparoscopic, and abdominal myomectomy: a comparison of surgical outcomes. Obstet Gynecol. 2011;117(2 Pt 1):256–65. doi:10.1097/AOG.0b013e318207854f.

    Article  PubMed  Google Scholar 

  46. Mettler L, Clevin L, Ternamian A, Puntambekar S, Schollmeyer T, Alkatout I. The past, present and future of minimally invasive endoscopy in gynecology: a review and speculative outlook. Minim Invasive Ther Allied Technol. 2013;22(4):210–26. doi:10.3109/13645706.2013.823451.

    Article  PubMed  Google Scholar 

  47. Schollmeyer T, Mettler L, Jonat W, Alkatout I. Roboterchirurgie in der Gynäkologie. Der Gynäkologe. 2011;44(3):196–201. doi:10.1007/s00129-010-2709-z.

    Google Scholar 

  48. George A, Eisenstein D, Wegienka G. Analysis of the impact of body mass index on the surgical outcomes after robot-assisted laparoscopic myomectomy. J Minim Invasive Gynecol. 2009;16(6):730–3. doi:10.1016/j.jmig.2009.07.014.

    Article  PubMed  Google Scholar 

  49. Falcone T, Parker WH. Surgical management of leiomyomas for fertility or uterine preservation. Obstet Gynecol. 2013;121(4):856–68. doi:10.1097/AOG.0b013e3182888478.

    Article  PubMed  Google Scholar 

  50. Garry R, Fountain J, Brown J, Manca A, Mason S, Sculpher M, et al. EVALUATE hysterectomy trial: a multicentre randomised trial comparing abdominal, vaginal and laparoscopic methods of hysterectomy. Health Technol Assess. 2004;8(26):1–154.

    CAS  PubMed  Google Scholar 

  51. Dietl J, Wischhusen J, Hausler SF. The post-reproductive Fallopian tube: better removed? Hum Reprod. 2011;26(11):2918–24. doi:10.1093/humrep/der274.

    Article  CAS  PubMed  Google Scholar 

  52. Worldwide AAMIG. AAGL position statement: robotic-assisted laparoscopic surgery in benign gynecology. J Minim Invasive Gynecol. 2013;20(1):2–9. doi:10.1016/j.jmig.2012.12.007.

    Article  Google Scholar 

  53. Meeks GR, Harris RL. Surgical approach to hysterectomy: abdominal, laparoscopy-assisted, or vaginal. Clin Obstet Gynecol. 1997;40(4):886–94.

    Article  CAS  PubMed  Google Scholar 

  54. Mazdisnian F, Kurzel RB, Coe S, Bosuk M, Montz F. Vaginal hysterectomy by uterine morcellation: an efficient, non-morbid procedure. Obstet Gynecol. 1995;86(1):60–4. doi:10.1016/0029-7844(95)00086-7.

    Article  CAS  PubMed  Google Scholar 

  55. Jenkins TR. Laparoscopic supracervical hysterectomy. Am J Obstet Gynecol. 2004;191(6):1875–84. doi:10.1016/j.ajog.2004.06.096.

    Article  PubMed  Google Scholar 

  56. Berner E, Qvigstad E, Myrvold AK, Lieng M. Pelvic pain and patient satisfaction after laparoscopic supracervical hysterectomy: prospective trial. J Minim Invasive Gynecol. 2013. doi:10.1016/j.jmig.2013.10.011.

    Google Scholar 

  57. Alkatout I, Mettler L, Beteta C, Hedderich J, Jonat W, Schollmeyer T, et al. Combined surgical and hormone therapy for endometriosis is the most effective treatment: prospective, randomized, controlled trial. J Minim Invasive Gynecol. 2013;20(4):473–81. doi:10.1016/j.jmig.2013.01.019.

    Article  PubMed  Google Scholar 

  58. Semm K. Hysterectomy via laparotomy or pelviscopy. A new CASH method without colpotomy. Geburtshilfe Frauenheilkd. 1991;51(12):996–1003. doi:10.1055/s-2008-1026252.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

The authors wish to thank Dawn Rüther for editing the manuscript.

Compliance with Ethics Guidelines

Conflict of Interest

Ibrahim Alkatout declares that he has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ibrahim Alkatout.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Alkatout, I. Surgical Treatment of Fibroids. Curr Obstet Gynecol Rep 3, 207–215 (2014). https://doi.org/10.1007/s13669-014-0090-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13669-014-0090-y

Keywords

Navigation