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d-Lactate and intestinal fatty acid-binding protein are elevated in serum in patients with acute ischemic stroke

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Abstract

Experimental studies suggest that the intestinal barrier is affected in ischemic stroke. d-Lactate and intestinal fatty acid-binding protein (IFABP) are markers of intestinal mucosa integrity and barrier function. Our purpose was to evaluate the serum concentrations of these markers in patients with acute ischemic stroke (AIS). We included patients with AIS and used healthy subjects as controls. Clinical, demographic and outcome measures were recorded. Blood was drawn within 24 h of symptom onset. Serum concentrations of d-Lactate and IFABP were determined using commercially available colorimetric and ELISA kits, respectively. We included a total of 61 patients (median age of 64 years). The majority of patients were male (57.4%). The most common cause of stroke was atherosclerosis (34.4%), followed by small-vessel disease and cardioembolic (32.7% each). Mean admission NIHSS score was 8. Median IFABP and d-Lactate concentrations were significantly higher in patients than in controls. Concentrations were not associated with stroke severity or 3-month outcome. Patients with large-artery atherosclerosis and cardioembolic etiology had higher d-Lactate values than patients with small-vessel disease. d-Lactate and IFABP were significantly elevated in patients with AIS. This suggests that there is disruption of the intestinal barrier in patients with AIS.

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Acknowledgements

We wish to acknowledge the staff at the Centro de Investigaciones Biomédicas del Noreste and at the Neurology Service of the Hospital Universitario.

Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Servicio de Neurología, Hospital Universitario “Dr. José E. González”, Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64700, Monterrey, NL, Mexico

    Carlos R. Camara-Lemarroy, Nicolás Escobedo-Zúñiga & Fernando Góngora-Rivera

  2. Centro de Investigaciones Biomédicas del Noreste, IMSS, Monterrey, Mexico

    Francisco J. Guzmán-de la Garza, Jorge Castro-Garza & Javier Vargas-Villarreal

  3. Departamento de Fisiologia, Facultad de Medicina, UANL, Monterrey, Mexico

    Francisco J. Guzmán-de la Garza

Authors
  1. Carlos R. Camara-Lemarroy
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  2. Nicolás Escobedo-Zúñiga
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  3. Francisco J. Guzmán-de la Garza
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  4. Jorge Castro-Garza
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  5. Javier Vargas-Villarreal
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  6. Fernando Góngora-Rivera
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Corresponding authors

Correspondence to Carlos R. Camara-Lemarroy or Fernando Góngora-Rivera.

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The authors declare that they no conflict of interest.

Ethical approval

This study was approved by the ethics committee of our institution (Ethics Committee of the School of Medicine, UANL).

Research involving human participants and/or animals

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Camara-Lemarroy, C.R., Escobedo-Zúñiga, N., Guzmán-de la Garza, F.J. et al. d-Lactate and intestinal fatty acid-binding protein are elevated in serum in patients with acute ischemic stroke. Acta Neurol Belg 121, 87–93 (2021). https://doi.org/10.1007/s13760-018-0940-x

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  • DOI: https://doi.org/10.1007/s13760-018-0940-x

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