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Pivotal MicroRNAs in Melanoma: A Mini-Review

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Abstract

Melanoma is a common skin cancer associated with ultraviolet light exposure and genetic variance. However, the etiology and molecular mechanisms of melanoma remain unknown. Recent studies have shown that microRNAs (miRNAs) can play key roles in the development and prognosis of this disease. In this study, we reviewed several pivotal miRNAs that may contribute to melanoma by involvement in the processes of invasion, migration, and metastasis of melanoma cells.

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Author Contributions

Li He and Lechun Lu conceived and designed this work. Lechun Lu, Zhenjun Deng, Jingang Hao, Dongyun Lei, and Yongjing He screened and analyzed the data. Lechun Lu, Zhenjun Deng, Jingang Hao, Dongyun Lei, and Li He wrote the manuscript.

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    Authors and Affiliations

    1. Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China

      Zhenjun Deng, Dongyun Lei, Lechun Lu & Li He

    2. Department of Medicine Image, Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China

      Jingang Hao

    3. Department of Plastic Surgery, Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China

      Yongjing He

    4. Department of Physiology, Kunming Medical University, Kunming, 650032, Yunnan, China

      Lechun Lu

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    1. Zhenjun Deng
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    Correspondence to Lechun Lu or Li He.

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    This work was supported by grants from the National Natural Science Foundation of China (NSFC; Grant Number 81560502), the National Natural Science Foundation of Yunnan Province (Grant Numbers 2013FB044 and 2014FB008), and the Education Department Fund of Yunnan Province (Grant Numbers 2014Y165, 2015Z082); and by a Doctoral Graduate Academic Newcomer Award of Yunnan Province (2014, 2015).

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    Z. Deng, J. Hao, and D. Lei contributed equally to this work and should be considered joint first authors.

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    Deng, Z., Hao, J., Lei, D. et al. Pivotal MicroRNAs in Melanoma: A Mini-Review. Mol Diagn Ther 20, 449–455 (2016). https://doi.org/10.1007/s40291-016-0219-y

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