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Th22 cells in allergic disease

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Summary

During the last decade, the field of T cell immunology started to confuse the scientific community. More and more subtypes of T helper cells and their counterparts in the innate immune system are described. We are just at the beginning to understand which specific function the distinct subtypes fulfill. Th22 cells are terminally differentiated and very specialized T helper cells characterized by the secretion of their signature cytokine IL-22 and lack of IL-4, IL-17 and IFN-γ. The main function of Th22 cells is to protect epithelial barrier organs such as skin and lung, but also to modulate inflamed and injured tissue. This review summarizes our current knowledge on Th22 cells and their function in allergic disease.

Cite this as Eyerich K, Eyerich S. Th22 cells in allergic disease. Allergo J Int 2015;24:1–7 DOI: 10.1007/s40629-015-0039-3

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Abbreviations

ACD:

Allergic contact dermatitis

AE:

Atopic eczema

AHR:

Aryl-hydrocarbon-receptor

CMC:

Chronic mucocutaneous candidiasis

FGF:

Fibroblast growth factor

IFN:

Interferon

IL:

Interleukin

ILC:

Innate lymhhoid cell

Lti:

Lymphoid-tissue inducer

MMP:

Matrix metalloproteinase

NK:

Natural killer cell

PDGF:

Platelet-derived growth factor

ROR:

RAR-related orphan receptor

TCR:

T-cell-receptor

TGF:

Transforming growth factor

Th:

T helper cell

TLR:

Toll-like-receptor

TNF:

Tumor necrosis factor

Treg:

Regulatory T cell

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Authors and Affiliations

  1. Department of Dermatology and Allergy, Technische Universität München, München, Germany

    Kilian Eyerich

  2. AUM – Center for Allergy and Environment, Technische Universität und Helmholtz Center Munich, Munich, Germany

    Stefanie Eyerich

  3. Department of Dermatology and Allergy, Technical University Munich, Biedersteiner Straße 29, 80802, Munich, Germany

    Kilian Eyerich

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  1. Kilian Eyerich
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  2. Stefanie Eyerich
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Correspondence to Kilian Eyerich.

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Eyerich, K., Eyerich, S. Th22 cells in allergic disease. Allergo J Int 24, 1–7 (2015). https://doi.org/10.1007/s40629-015-0039-3

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