Abstract
Lipase-catalysed alcoholysis and hydrolysis of 2′,3′,5′-tri-O-acetyluridine (1a) and 2′,3′,5′-tri-O-acetyl-2′-C-methyluridine (1b) were studied. Conditions for full and regioselective deacetylation of 1aand 1b are shown in the present work. New compound 2′,3′-di-O-acetyl-2′-C-methyluridine (3b) was prepared by regioselective lipase-catalysed deacetylation.
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Iglesias, L.E., Zinni, M.A., Gallo, M. et al. Complete and regioselective deacetylation of peracetylated uridines using a lipase. Biotechnology Letters 22, 361–365 (2000). https://doi.org/10.1023/A:1005620617554
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DOI: https://doi.org/10.1023/A:1005620617554