Skip to main content
SpringerLink
Log in

Expression of Estrogen Receptors Alpha and Beta in Human Meningiomas

  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

The predominance of meningiomas in females, their accelerated growth during the luteal phase of the menstrual cycle and during pregnancy; and the association between meningiomas and breast cancer has led to a number of studies examining the potential role of steroids on the growth of meningiomas. It is generally agreed that the majority of meningiomas possess the progesterone and androgen receptor. There are numerous discrepancies in the literature among the results for estrogen receptor (ER). The aim of this study was to examine the expression of ER-α mRNA and the recently described novel ER, ER-β in meningiomas. Using reverse transcription and polymerase chain reaction (RT-PCR) Southern blot analysis thirty-four meningiomas were examined for the presence of ER-α and ER-β. Forty-four percent of meningiomas showed a strong band for ER-β mRNA and sixty-eight percent of meningiomas showed a strong band for ER-α mRNA. The involvement of ER-β in meningioma biology should be examined further, given the differences in the ER-α and ER-β gene products.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Burger PC, Vogel FS: Meningiomas. In: Surgical Pathology of the Nervous System and its Coverings. J. Wiley, New York, 1991, pp 67–68

    Google Scholar 

  2. Russell DS, Rubinstein LJ: Pathology of Tumorous of the Nervous System. 5th edn., 1898, pp 449–532

  3. Bickerstaff ER, Small JM, Guest IA: The relapsing course of certain meningiomas in relation to pregnancy and menstruation. J Neurol Neurosurg Psychiatry 21: 89–91, 1958

    Google Scholar 

  4. Roelvinck NCA, Kamphorst W, van Alphen HAM, Rao R: Pregnancy-related primary brain and spinal tumors. Arch Neurol 44: 209–215, 1987

    Google Scholar 

  5. Schoenberg BS, Christine BW, Wisnant JP: Nervous system neoplasms and primary malignances of other sites. The unique association between meningiomas and breast cancer. Neurology 25: 705–712, 1975

    Google Scholar 

  6. Emry JK: The association between breast cancer and meningiomas. Master's thesis (Biometry), University of Southern California, Los Angeles, California. 1984

    Google Scholar 

  7. Donell MS, Meyer GA, Donegan WL: Estrogen-receptor protein in intracranial meningiomas. Cancer 50: 499–502, 1979

    Google Scholar 

  8. Balaauw G, Blankenstein MA, Lamberts SWJ: Sex steroid receptors in human meningiomas. Acta Neurochirurgica 79: 42–47, 1986

    Google Scholar 

  9. Blankenstein MA, Blaauw G, Lamberts WJ, Mulder E: Presence of progesterone receptors and absence of oestrogen receptors in human intracranial meningioma cytosols. Eur J Cancer Clin Oncol 19: 363–370, 1983

    Google Scholar 

  10. Blankenstein MA, Blaauw G, Lamberts SWJ: Progestin and estrogen receptors in human meningiomas. Clinical Neuropharmacology 7: 363–367, 1984

    Google Scholar 

  11. Bouillot P, Pellissier J-F, Devictor B, Graziani N, Bianco N, Grisoli G, Branger DF: Quantitative imaging of estrogen and progesterone receptor, estrogen-regulated protein and growth fraction: immunocytochemical assays in 52 meningiomas. J Neurosurg 81: 765–773, 1994

    Google Scholar 

  12. Bozetti C, Camisa R, Nizzoli R, Manotti L, Guazzi A, Naldia N, Mazza S, Nizzoli V, Cocconi G: Estrogen and progesterone receptors in human meningiomas: biochemical and immunocytochemical evaluation. Surg Neurol 43: 230–234, 1995

    Google Scholar 

  13. Brandis A, Mirzai S, Tatagiba M, Walter GF, Samii M, Ostertag H: Immunohistochemical detection of female sex hormone receptors in meningiomas: correlation with clinical and histological features. Neurosurgery 33: 212–218, 1993

    Google Scholar 

  14. Brentani MM, Lopes MTP, Martins VR, Please JP: Steroid receptors in intracranial tumors. Clinical Neuropharmacology 7: 347–350, 1984

    Google Scholar 

  15. Cahill DW, Bashirelahi N, Solomn LW, Dalton T, Salcman M, Ducker TB: Estrogen and progesterone receptors in meningiomas. J Neurosurgery 60: 985–993, 1984

    Google Scholar 

  16. Carroll RS, Glowacka D, Dashner K, Black PM: Progesterone receptor expression in meningiomas. Cancer Research 53: 1312–1316, 1993

    Google Scholar 

  17. Halper J, Colvard DS, Scheithauer BW, Jiang N-S, Press MF, Graham ML, Riehl E, Laws ER: Estrogen and progesterone receptors in meningiomas: comparision of nuclear binding, dextran-coated charcol, and immunoperoxidase staining assays. Neurosurgery 25: 546–553, 1989

    Google Scholar 

  18. Hayward E, Whitwell H, Paul KS, Barnes DM: Steroid receptors in human meningiomas. Clinical Neuropharmacology 7: 351–356, 1984

    Google Scholar 

  19. Hsu DW, Efird JT, Hedley-Whyte ET: Progesterone and estrogen receptors in meningiomas: prognostic considerations. J Neurosurg 86: 113–120, 1997

    Google Scholar 

  20. Lesch K-P, Schott W, Engl H-G, Gross S, Thierauf P: Gonadal steroid receptors in meningiomas. J Neurol 234: 328–333, 1987

    Google Scholar 

  21. Lesch KP, Schott DW, Gross S: Estrophilin immunoreactivity versus estrogen receptor binding activity in meningiomas: evidence for multiple estrogen binding sites. Surg Neurol 28: 181–188, 1987

    Google Scholar 

  22. Lesch KP, Gross S: Estrogen receptor immunoreactivity in meningiomas. Comparison with the binding activity of estrogen, progesterone, and androgen receptors. J Neurosurgery 67: 237–243, 1987

    Google Scholar 

  23. Markwalder TM, Zava DT, Goldhirsch A, Markwalder RV: Estrogen and progesterone receptors in meningiomas in relation to clinical and pathologic features. Surg Neurol 20: 42–47, 1983

    Google Scholar 

  24. Markwalder TM, Markwalder RV, Zava DT: Estrogen and progestin receptors in meningiomas: Clinicopathological correlations. Clinical Neuropharmacology 4: 368–374, 1984

    Google Scholar 

  25. Martuza RL, Miller DC, MacLaughlin DT: Estrogen and progestin binding by cytosolic and nuclear fractions of human meningiomas. J Neurosurg 62: 750–756, 1985

    Google Scholar 

  26. Maxwell M, Galanpoulow T, Golden J, Antoniades HN: Expression of androgen and progesterone receptors in primary human meningiomas. J Neurosurg 78: 456–462, 1993

    Google Scholar 

  27. Moguilewsky M, Peruiset BF, Verzat C, Philibert D, Philippon J, Poisson M: Cytosolic and nuclear sex steroid receptors in meningiomas. Clinical Neuropharmacology 7: 375–381, 1984

    Google Scholar 

  28. Poisson M, Magdelenat H, Foncin JF: Receteurs d'oestrogenes et de progesterone dans les meningiomes. Rev Neurol (Paris) 136: 193–203, 1980

    Google Scholar 

  29. Schrell UMH, Adams EF, Fahlbusch R, Greb R, Jirikowshi G, Prior R, Ramalho-Ortigao FJ: Hormonal dependency of cerebral meningiomas, Part I: Female sex steroid receptors and this significance as specific markers for adjuvant medical therapy. J Neurosurgery 73: 743–749, 1990

    Google Scholar 

  30. Schwartz MR, Randolph RL, Cech DA, Rose JE, Panko WB: Steroid hormone binding macromolecules in meningiomas. Cancer 53: 922–927, 1984

    Google Scholar 

  31. Smith DA, Cahill DW: The biology of meningiomas. Neurosurgery clinics of North America. 5: 201–215, 1994

    Google Scholar 

  32. Tilzer LL, Plapp FV, Evans JP, Stone D, Alward K: Steroid receptor proteins in human meningiomas. Cancer 49: 633–636, 1982

    Google Scholar 

  33. Gibelli N, Zibera C, Butti G, Assietti R, Sica G, Scerrati M, Iacopino F, Roselli R, Paoletti P, Robustelli della Cuna: Hormonal modulation of brain tumors growth: a cell culture study. Act Neuchir (Wien) 101: 129–133, 1989

    Google Scholar 

  34. Grunberg SM, Weiss MH, Spitz IM, Ahmadi J, Sandun A, Russell CA, Lucci L, Stevenson LL: Treatment of unresectable meningiomas with the antiprogesterone agent mifepristone. J Neurosurgery 74: 861–866, 1991

    Google Scholar 

  35. Jay JR, MacLaughin DT, Riley KR, Martuza RL: Modulation of meningioma cell growth by sex steroid hormones in vitro. J Neurosurg 62: 757–762, 1985

    Google Scholar 

  36. Maiuri F, Montagnani S, Gallicchio B, Carandent M, Lanza GG, D'andrea F: Oestrogen and progesterone sensitivity in cultured meningioma cells. Neurol Res 11: 9–13, 1989

    Google Scholar 

  37. Olson JJ, Beck DW, Schlechte J: Hormonal manipulation of meningiomas in vitro. J Neurosurg 65: 99–107, 1986

    Google Scholar 

  38. Waelti ER, Markwalder TM: Endocrine manipulation of meningiomas with medroxyprogesterone acetate. Effect of MPA on growth of primary meningioma cells in monolayer tissue culture. Surg Neurol 31: 96–100, 1989

    Google Scholar 

  39. Blankenstein MA, Berns PMJ, Blaauw G, Mulder E, Thijssen JHH: Search for estrogen receptors in human meningioma tissue sections with a monoclonal antibody against the human estrogen receptor. Cancer Research (Suppl) 46: 4268s–4270s, 1986

    Google Scholar 

  40. Blankenstein MA, Koehorst SGA, van der Kallen CJH, Jacobs HM, van Spriel AB, Donker GH, van't Verlaat JW, Blaauw G, Thijssen JHH: Oestrogen receptor independent expression of progestin receptors in human meningioma – a review. Journal of Steroid Biochemistry and Molecular Biology 53: 361–365, 1995

    Google Scholar 

  41. Koehorst SGA, Jacobs HM, Tilanus MGJ, Bouwens AG, Thijssen JH, Blankenstein MA: Aberrant oestrogen receptor species in human meningioma tissue. J Steroid Biochem Molec Biol 43: 57–61, 1992

    Google Scholar 

  42. Koehorst SGA, Jacobs HM, Thijssen JHH, Blankenstein MA: Wild type and alternatively spliced estrogen receptor messenger RNA in human meningioma tissue and MCF7 breast cancer cells. J Steroid Biochem Molec Biol 45: 227–233, 1993

    Google Scholar 

  43. Vacca A, Fazio VM, Gandini O, Oppido P, Delfini R, Frati L, Gulino A: Altered restriction pattern of the putative DNA binding domain of estrogen receptor or related genes in primary human meningiomas. Int J Cancer 43: 567–569, 1989

    Google Scholar 

  44. Mosselman S, Polman J, Dijkema: ER-β: identification and characterization of a novel estrogen receptor. FEBS 392: 49–53, 1996

    Google Scholar 

  45. Kuiper GGJM, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, Gustafsson J: Comparison of the ligand binding specificity and transcript distribution of estrogen receptorsα andβ. Endocrinology 138: 863–870, 1997

    Google Scholar 

  46. Chirgwin JA, Przybyla AE, MacDonald RJ: Isolation of biologically active ribonucleic acid from sources enriched with ribonuclease. Biochemistry 8: 5294–5299, 1979

    Google Scholar 

  47. Green GL, Gilna P, Waterfield M, Baker A, Hort Y, Shine J: Sequence and expression of human estrogen receptor complementary DNA. Science 231: 1150–1156, 1986

    Google Scholar 

  48. Feinberg AP, Vogelstein B: A technique for radiolabelling DNA restriction fragments to high specific activity. Anal Biochem 132: 6–13, 1983

    Google Scholar 

  49. Dotzlaw H, Leygue E, Watson PH, Murphy LC: Expression of estrogen receptor-beta in human breast tumors. J Clin Endo Metabolism 82: 2371–2374, 1997

    Google Scholar 

  50. Leygue E, Dotzlaw H, Watson PH, Murphy LC: Altered estrogen alpha and beta messenger RNA expression during human breast tumorigenesis. Cancer Research 58: 3197–3201, 1998

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neurosurgical Laboratories, Brigham and Women's Hospital, USA

    Rona S. Carroll, Jianping Zhang & Peter McL Black

  2. Brain Tumor Center, Brigham and Women's Hospital, USA

    Rona S. Carroll, Jianping Zhang & Peter McL Black

  3. The Children's Hospital, USA

    Rona S. Carroll, Jianping Zhang & Peter McL Black

  4. Department of Surgery, Harvard Medical School, Boston, MA, USA

    Peter McL Black

  5. Dana Farber Cancer Institute, USA

    Rona S. Carroll, Jianping Zhang & Peter McL Black

Authors
  1. Rona S. Carroll
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jianping Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Peter McL Black
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Carroll, R.S., Zhang, J. & Black, P.M. Expression of Estrogen Receptors Alpha and Beta in Human Meningiomas. J Neurooncol 42, 109–116 (1999). https://doi.org/10.1023/A:1006158514866

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1006158514866

Search

Navigation