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The Human Response to Endotoxin

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Sepsis

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References

  1. Baue AE. Multiple organ failure, multiple organ dysfunction syndrome, and systemic inflammatory response syndrome. Why no magic bullets? Arch Surg 1997;132:703-707.

    PubMed  Google Scholar 

  2. Barriere SL, Lowry SF. An overview of mortality risk prediction in sepsis. Crit Care Med 1995;23:376-393.

    PubMed  Google Scholar 

  3. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM consensus conference committee. Chest 1992;101:1644-1655.

    PubMed  Google Scholar 

  4. Davies MG, Hagen PO. Systemic inflammatory response syndrome. Br J Surg 1997;84:920-935.

    PubMed  Google Scholar 

  5. Schumann RR, Leong SR, Flaggs GW, et al. Structure and function of lipopolysaccharide binding protein. Science 1990; 249:1429-1431.

    PubMed  Google Scholar 

  6. Mathison J, Tobias P, Wolfson E, Ulevitch R. Regulatory mechanisms of host responsiveness to endotoxin (lipopolysaccharide). Pathobiology 1991;59:185-188.

    PubMed  Google Scholar 

  7. Pugin J, Schürer-Maly CC, Letucq D, Moriarty A, Ulevitch RJ, Tobias PS. Lipopolusaccharide activation of human endothelial and epithelial cells is mediated by lipoposaccharide-binding protein and soluble CD14. Immunology 1993;90:2744-2748.

    Google Scholar 

  8. Wurfel MW, Kunitake ST, Lichenstein H, Kane JP, Wright SD. Lipopolysaccharide (LPS) binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS. J Exp Med 1994;181:1743-1754.

    Google Scholar 

  9. Feingold KR, Funk JL, Moser AH, Shigenaga JK, Rapp JH, Grunfeld C. Role of circulating lipoproteins in protection from endotoxin activity. Infect Immun 1995;63:2041-2046.

    PubMed  Google Scholar 

  10. Marra MN, Wilde CG, Griffith JE, Snable JL, Scott RW. Bactericidal/permeability-increasing protein has endotoxin neutralizing activity. J Immunol 1990;144:662-666.

    PubMed  Google Scholar 

  11. Hochstein HD, Mills DF, Outschoorn AS, Rastogi SC. The processing and collaborative assay of reference endotoxin. J Biol Stand 1983;11:251-260.

    PubMed  Google Scholar 

  12. Suffredini AF, Fromm FE, Parker MM, Brenner M, Kovacs JA, Wesley RA, Parillo JE. The cardiovascular response of normal humans to the administration of endotoxin. N Engl J Med 1989;321:280-287.

    PubMed  Google Scholar 

  13. Bozkurt B, Kribbs SB, Clubb FJ, et al. Pathophysiologically relevant concentrations of tumor necrosis factor-alpha promote progressive left ventricular dysfunction and remodeling in rats. Circulation 1998;97:13822-1391.

    Google Scholar 

  14. Fong Y, Marano MA, Moldawer LL, et al. The acute splanchnic and peripheral tissue metabolic response to endotoxin in humans. J Clin Invest 1990;85:1896-1904.

    PubMed  Google Scholar 

  15. Rock CS, Coyle SM, Keogh CV, et al. Influence of hypercortisolemia on the acute-phase protein response to endotoxin in humans. Surgery 1992;112:467-474.

    PubMed  Google Scholar 

  16. Shedlofsky Sl, Israel BC, McClain CJ, Hill DB, Blouin RA. Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism. J Clin Invest 1994;94:2209-2214.

    PubMed  Google Scholar 

  17. Suffredini AF, Shelhamer JH, Neumann RD, Brenner M, Baltaro RJ, Parrillo JE. Pulmonary and oxygen transport effects of intravenously administered endotoxin in normal humans. Am Rev Respir Dis 1992;145:1398-1403.

    PubMed  Google Scholar 

  18. Pajkrt D, Manten A, van der Poll T et al. Modulation of cytokine release and neutrophil function by granulocyte colony-stimulating factor during endotoxemia in humans. Blood 1997;90:1415-1424.

    PubMed  Google Scholar 

  19. Korth C, Mullington J, Schreiber W, Pollmacher T. Influence of endotoxin on daytime sleep in humans. Infect Immun 1996;64:1110-1115.

    PubMed  Google Scholar 

  20. Starnes CO. Coley's toxin in perspective. Nature 1992;357:11-12.

    PubMed  Google Scholar 

  21. Engelhardt R, Mackensen A, Galanos C. Phase I trial of intravenously administered endotoxin (Salmonella abortus equi) in cancer patients. Cancer Res 1991;51:2524-2530.

    PubMed  Google Scholar 

  22. Lin E, Calvano SE, Lowry SF. Cytokine response in abdominal surgery. In: Schein M, Wise L (eds). Cytokines and the Abdominal Surgeon. Austin: Landes, 1998;17-34.

    Google Scholar 

  23. Van der Poll T, Lowry SF. Tumor necrosis factor in sepsis: Mediator of multiple organ failure or essential part of host defense? Shock 1995;3:1-12.

    Google Scholar 

  24. Van der Poll T, Lowry SF. Endogenous mechanisms regulating TNF and IL-1 during sepsis. In: Vincent JL (ed). Yearbook of Intensive Care and Emergency Medicine, 1995;385-397.

  25. Lowry SF, Calvano SE. Soluble cytokine and hormonal mediators of immunity and inflammation. In: Howard RJ, Simmons RL (eds). Surgical Infectious Diseases. 3rd ed. Appleton and Lange, 1995;313-326.

  26. Rogy MA, Coyle SM, Oldenburg HSA, et al. Persistently elevated soluble tumor necrosis factor receptor and interleukin-1 receptor antagonist levels in critically ill patients. J Am Coll Surg 1994;178:132-138.

    PubMed  Google Scholar 

  27. Van Zee KJ, Kohno T, Fischer E, Rock CS, Moldawer LL, Lowry SF. Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor in vitro and in vivo. Proc Natl Acad Sci USA 1992;89:4845-4849.

    PubMed  Google Scholar 

  28. Aderka D, Engelmann H, Maor Y, Brakebusch C, Wallach D. Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors. J Exp Med 1992;175:323-329.

    PubMed  Google Scholar 

  29. Granowitz EV, Santos AA, Poutsiaka DD, et al. Production of interleukin-1 receptor antagonist during experimental endotoxaemia. Lancet 1991;338:1423-1424.

    PubMed  Google Scholar 

  30. Van der Poll T, van Deventer SJH, ten Cate H, Levi M, ten Cate JW. Tumor necrosis factor is involved in the appearance of interleukin 1 receptor antagonist in endotoxemia. J Infect Dis 1994;169:665-667.

    PubMed  Google Scholar 

  31. Fischer E, van Zee KJ, Marano MA, et al. Interleukin-1 receptor antagonist circulates in experimental inflammation and in human disease. Blood 1992;79(9):2196-2200.

    PubMed  Google Scholar 

  32. Leng SX, Elias JA. Interleukin-11 inhibits macrophage interleukin-12 production. J Immunol 1997;159:2161-2168.

    PubMed  Google Scholar 

  33. Alleva DG, Kaser SB, Monroy MA, Fenton MJ, Beller Dl. IL-15 functions as a potent autocrine regulator of macrophage proinflammatory cytokine production. J Immunol 1997;159:2941-2951.

    PubMed  Google Scholar 

  34. Karres I, Kremer JP, Steckholzer U, Kenney JS, Ertel W. Transforming growth factor-1 inhibits synthesis of cytokines in endotoxin-stimulated human whole blood. Arch Surg 1996;131:1310-1317.

    PubMed  Google Scholar 

  35. Lin E, Katz JA, Calvano SE, Coyle SM, Randhawa S, Shahin I, Kumar A Lowry SF. The influence of human endotoxemia upon CD95-induced apoptosis. Arch Surg 1998;133:1322-1327.

    PubMed  Google Scholar 

  36. Casey LC, Balk RA, Bone RC. Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Ann Intern Med 1993;119:771-778.

    PubMed  Google Scholar 

  37. Meduri GU, Headley S, Kohler G, et al. Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS: Plasma IL-1 and IL-6 levels are consistent and efficient predictors of outcome over time. Chest 1995;107:1062-1073.

    PubMed  Google Scholar 

  38. Schindler R, Mancilla J, Endres S, Ghorbani R, Clark R, Dinarello CA. Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. Blood 1990;75:40-47.

    PubMed  Google Scholar 

  39. Tilg H, Trehu E, Atkins MB, Dinarello CA, Mier JW. Interleukin-6 (IL-6) as an antiinflammatory cytokine: Induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55. Blood 1994;83:113-118.

    PubMed  Google Scholar 

  40. Calvano SE, Coyle SM, Barbosa KS, Barie PS, Lowry SF. Multivariate analysis of the nine disease-associated variables for outcome prediction in patients with sepsis. Arch Surg 1998;133:1347-1350.

    PubMed  Google Scholar 

  41. Oldenburg HSA, Rogy MA, Lazarus DD, et al. Cachexia and the acute-phase protein response in inflammation are regulated by interleukin-6. Eur J Immunol 1993;23:1889-1894.

    PubMed  Google Scholar 

  42. Berger D, Bolke E, Seidelmann M, et al. Time-scale of interleukin-6, myeloid related proteins (MRP), C reactive protein (CRP), and endotoxin plasma levels during the postoperative acute phase reaction. Shock 1997;7(6):422-426.

    PubMed  Google Scholar 

  43. Lee A, Whyte KB, Haslett C. Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators. J Leuk Biol 1993;54:283-288.

    Google Scholar 

  44. Biffl WL, Moore EE, Moore FA, et al. Interleukin-6 delays neutrophil apoptosis. Arch Surg 1996;131:24-30.

    PubMed  Google Scholar 

  45. Marchant A, Deviere J, Byle B, de Grootte D, Vincent JL, Goldman M. Interleukin-10 production during septicaemia. Lancet 1994;343:707-708.

    PubMed  Google Scholar 

  46. Van der Poll T, Janse J, Levi M, ten Cate H, ten Cate JW, van Deventer SJH. Regulation of interleukin 10 release by tumor necrosis factor in humans and chimpanzees. J Exp Med 1994;180:1985-1988.

    Google Scholar 

  47. Van der Poll T, Coyle SM, Barbosa K, Braxton CC, Lowry SF. Epinephrine inhibits tumor necrosis factor-and potentiates interleukin 10 production during human endotoxemia. J Clin Invest 1996;97(3):713-719.

    PubMed  Google Scholar 

  48. Gerard C, Bruyns C, Marchant A, et al. Interleukin-10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J Exp Med 1993;177:547-550.

    PubMed  Google Scholar 

  49. Leeuwenberg JFM, Jeunhomme TMAA, Buurman WA. Slow release of soluble TNF receptors by monocytes in vitro. J Immunol 1994;152:4036-4040.

    PubMed  Google Scholar 

  50. Richardson RP, Rhyne CD, Fong Y, et al. Peripheral blood leukocyte kinetics following in vivo lipopolysaccharide (LPS) administration to normal human subjects. Ann Surg 1989;210:239-245.

    PubMed  Google Scholar 

  51. Van der Poll T, Levi M, van Deventer SJ, et al. Differential effects of anti-tumor necrosis factor monoclonal antibodies on systemic inflammatory responses in experimental endotoxemia in chimpanzees. Blood 1994;83:446-451.

    PubMed  Google Scholar 

  52. Van der Poll T, Levi M, Hack CE, et al. Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees. J Exp Med 1994;179:1253-1259.

    PubMed  Google Scholar 

  53. Van Zee KJ, DeForge LE, Fischer E, et al. IL-8 in septic shock, endotoxemia, and after IL-1 administration. J Immunol 1991;146:3478-3482.

    PubMed  Google Scholar 

  54. Van Zee KJ, Coyle SM, Calvano SE, et al. Influence of IL-1 receptor blockade on the human response to endotoxemia. J Immunol 1995;154:1499-1507.

    PubMed  Google Scholar 

  55. Van Deventer SJH, Hack CE, Wolbink GJ, Voermans HJ, Strack van Schijndel RJM, ten Cate JW, Thijs LG. Endotoxin-induced neutrophil activation. The role of complement revisited. Prog Clin Biol Res 1991;367:101-109.

    PubMed  Google Scholar 

  56. Von der Möhlen MAM, van der Poll T, Jansen J, Levi M, van Deventer SJH. Release of bactericidal/permeability-increasing protein in experimental endotoxemia and clinical sepsis: Role of tumor necrosis factor. J Immunol 1996;156:4969-4973.

    PubMed  Google Scholar 

  57. Moore FD, Moss NA, Revhaug A, Wilmore DW, Mannick JA, Rodrick ML. A single dose of endotoxin activates neutrophils without activating complement. Surgery 198;102:200-205.

  58. Lin E, Lowry SF, Calvano SE. Systemic response to injury. In: Schwartz SI, Shires GT, Spencer FC, Daly JM, Fischer JE, Galloway AC. Principles of Surgery, 7th ed. New York: McGraw-Hill, 1998, 3-51.

    Google Scholar 

  59. Grobmyer SR, Barie PS, Nathan CF, Fuortes M, Lin E, Lowry SF, Wright CD, Weyant MJ, Hydo L, Reeves F, Shiloh MU, Ding A. Secretory leukocyte protease inhibitor, an inhibitor of neutrophil activation, is elevated in serum in human sepsis and experimental endotoxemia. Crit Care Med 1999, (in press).

  60. Van der Poll T, Calvano SE, Kumar A, Braxton CC, Coyle SM, Barbosa K, Moldawer LL, Lowry SR. Endotoxoin induces downregulation of tumor necrosis factor receptors on circulating monocytes and granulocytes in humans. Blood 1995;86:2754-2759.

    PubMed  Google Scholar 

  61. Calvano SE, van der Poll T, Coyle SM, Barie PS, Moldawer LL, Lowry SF. Monocyte tumor necrosis factor receptor levels as a predictor of risk in human sepsis. Arch Surg 1996;131:434-437.

    PubMed  Google Scholar 

  62. Van Deventer SJH, Büller HR, ten Cate JW, Aarden LA, Hack CE, Sturk A. Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic and complement pathways. Blood 1990;76:2520-2526.

    PubMed  Google Scholar 

  63. Suffredini AF, Harpel PC, Parillo JE. Promotion and subsequent inhibition of plasminogen activator after administration of intravenous endotoxin to normal subjects. N Engl J Med 1989;320:1165-1172.

    PubMed  Google Scholar 

  64. Von der Möhlen MAM, van Deventer SJ, Levi M, et al. Inhibition of endotoxin-induced activation of the coagulation and fibrinolytic pathways using a recombinant-binding protein (rBPI23). Blood 1995;85:3437-3443.

    PubMed  Google Scholar 

  65. De La Cadena RA, Suffredini AF, Page JD, et al. Activation of the kallikrein-kinin system after endotoxin adminstration to normal human volunteers. Blood 1993;81:3313-3317.

    PubMed  Google Scholar 

  66. Levi M, ten Cate H, Bauer KA, et al. Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees. J Clin Invest 1994;93:114-120.

    PubMed  Google Scholar 

  67. Santos AA, Scheltinga MR, Lynch E, et al. Elaboration of interleukin-1-receptor antagonist is not attenuated by glucocorticoids after endotoxemia. Arch Surg 1993;128:138-144.

    Google Scholar 

  68. Barber AE, Coyle SM, Marano MA, et al. Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man. J Immunol 1993;150:1999-2006.

    PubMed  Google Scholar 

  69. Fong Y, Matthews DE, He W, Marano M, Moldawer LL, Lowry SF. Whole body and splanchnic [1-13C] leucine, [ring-2H5] phenylalanine, and [6,6-2H5] glucose kinetics during endotoxemia in man. Am J Physiol 1994;266:R419-R425.

    PubMed  Google Scholar 

  70. Van der Poll T, Braxton CC, Coyle SM, Boermeester MA, Wang JC, Jansen PM, Montegut WJ, Calvano SE, Hack CE, Lowry SF. Effect of hypertriglyceridemia on endotoxin responsiveness in humans. Infect Immun 1995;63:3396-3400.

    PubMed  Google Scholar 

  71. Lin E, Coyle SM, Randhawa S, et al. Polymyxin-622 prevents endotoxin-induced inflammation in humans. Surg Forum 1998;49:6-8.

    Google Scholar 

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  1. Department of Surgery Division of Surgical Sciences, Robert Wood Johnson Medical School, New Brunswick, New Jersey

    Stephen F. Lowry

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Lin, E., Lowry, S.F. The Human Response to Endotoxin. Sepsis 2, 255–262 (1998). https://doi.org/10.1023/A:1009890031293

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