Abstract
Objective: To assess the effectiveness of ondansetron in relieving symptoms of nausea and vomiting which were refractory to metoclopramide and cyclizine, in a patient receiving iloprost infusions.Method: Case observation in a series of 7 infusions.Results: Ondansetron reduced WHO symptom scores of vomiting from Grade 2 to Grade 0. Symptoms of nausea were abolished on some occasions.Conclusion: Ondansetron was found to be effective at abolishing symptoms of vomiting and partially effective against symptoms of nausea. It may prove to be a useful treatment modality to allow the patient to tolerate further infusions of iloprost where nausea and vomiting has failed to respond to other agents.
References
Grant S, Goa K. Iloprost. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential on peripheral vascular disease, myocardial ischaemic and extracorporeal circulation procedures. Drugs 1992;43:889-924
Lawhorn S, Lawhorn C, Davison C. Ondansetron eliminates vomiting associated with prostacyclin in a patient awaiting lung transplantation. J Heart Lung Transplant 1997;16:472-3
Fisch A, Tobasch K, Veit K, Meyer J, Darius H. Prostacyclin receptor desensitisation is a reversible phenomenon in human platelets. Circulation 1997:96,756-60
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Roome, C., Thompson, J. Pre‐emptive metoclopramide and ondansetron for nausea and vomiting associated with iloprost infusions. Pharm World Sci 23, 122 (2001). https://doi.org/10.1023/A:1011231507085
Issue Date:
DOI: https://doi.org/10.1023/A:1011231507085