Abstract
Strong amplification of chirality occurs in dynamic, but highly ordered, helical columns in n-butanol, for which one chiral seed molecule suffices to render a column of 400 molecules to become homochiral. The chiral columns are formed in a thermally dependent stepwise process. The transition from achiral stacks to helical columns is highly cooperative owing to well-defined intermolecular interactions. `Sergeant and Soldiers' measurements allow for the calculation of the association constant and cooperativity length of the homochiral segments. The `Sergeant and Soldiers' data on the number of molecules within a column show a strikingly good match with data obtained from a theoretical model describing the self-assembly of the discotic molecules as a function of temperature and concentration.
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Brunsfeld, L., Lohmeijer, B.G., Vekemans, J.A. et al. Amplification of Chirality in Helical Supramolecular Columns. Journal of Inclusion Phenomena 41, 61–64 (2001). https://doi.org/10.1023/A:1014417621324
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DOI: https://doi.org/10.1023/A:1014417621324