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Application of Mass Spectrometry and Chromatography–Mass Spectrometry in Drug Analysis

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Abstract

The review is devoted to the use of mass spectrometry and chromatography–mass spectrometry in various areas of pharmaceutical chemistry. The role of the above techniques in the structural identification of impurities in drug preparations and in the determination of the biotransformation behavior of pharmaceuticals in human and animal bodies is shown. The inactivation of drugs under the action of external factors (oxidation by atmospheric oxygen and the effects of moisture, heat, and light) is illustrated. The use of various ionization techniques and the spectra of metastable ions for determining the structures of components of biologically active substances are exemplified.

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Klyuev, N.A. Application of Mass Spectrometry and Chromatography–Mass Spectrometry in Drug Analysis. Journal of Analytical Chemistry 57, 462–479 (2002). https://doi.org/10.1023/A:1015733515592

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