Abstract
The ability of synthetic derivatives of the siderophore tripeptide of N 5-hydroxy-N 5-acetyl-l-ornithine to promote the growth of various strains of mycobacteria and Gram negative bacteria was found to depend significantly on the hydrophobic nature of the derivative. Although the tripeptide of N 5-hydroxy-N 5-acetyl-l-ornithine is not normally utilized by mycobacteria, an N-terminal palmitoyl derivative mimicked natural mycobactin J in all studies.
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Lin, YM., Miller, M.J. & Möllmann, U. The remarkable hydrophobic effect of a fatty acid side chain on the microbial growth promoting activity of a synthetic siderophore. Biometals 14, 153–157 (2001). https://doi.org/10.1023/A:1016666414848
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DOI: https://doi.org/10.1023/A:1016666414848