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Edrophonium Provocative Testing During Electrogastrography (EGG) (Effects on Dyspeptic Symptoms and the EGG)

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Abstract

The aim of this study was to determine whetheredrophonium induces dyspeptic symptoms and/or gastricmyoelectric changes in normal subjects and patients withfunctional dyspepsia. Eighteen normal controls and 28 patients with functional dyspepsiaunderwent electrogastrography (EGG) with edrophoniumadministration. After EGG recording with 1-hr fastingand 2-hr postprandial periods, subjects received anintravenous infusion of saline (placebo) followed byedrophonium 10 mg. After each injection, the EGG wasrecorded for 15 min and symptoms scored. Patients withfunctional dyspepsia had significantly more frequent gastrointestinal symptoms in response toedrophonium than normal controls. Edrophonium had noeffect on EGG dominant frequency, but increased thepower of the dominant frequency in both controls anddyspeptic patients. In the dyspeptic patients,reproduction of the patient's symptoms was associatedwith an increase in the power of the dominant frequency,whereas when no symptoms were produced, there was nochange in power. Overall, 21 of 28 dyspeptic patients(75%) had either an abnormal baseline EGG (N = 10) or anormal EGG and positive edrophonium test (N = 11). Inconclusion, edrophonium administration can reproduce symptoms in some dyspeptic patients.Symptoms after edrophonium administration may be relatedto either more vigorous gastric contractions and/orincreased visceral perception of normal gastric contractions.

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Authors
  1. Eugene S. Bonapace
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  2. Henry P. Parkman
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  3. Robert S. Fisher
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Bonapace, E.S., Parkman, H.P. & Fisher, R.S. Edrophonium Provocative Testing During Electrogastrography (EGG) (Effects on Dyspeptic Symptoms and the EGG). Dig Dis Sci 43, 1494–1500 (1998). https://doi.org/10.1023/A:1018806729894

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  • DOI: https://doi.org/10.1023/A:1018806729894

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