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Effects of Quercetin on Liver Damage in Rats with Carbon Tetrachloride-Induced Cirrhosis

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Abstract

Flavonoids are reported to exhibit a wide variety of biological effects, including antioxidant and free radical-scavenging activities. Evidence of oxidative reactions is often associated with various chronic disease processes characterized by accumulation of connective tissue. This study was aimed to investigate the protective effects of chronic administration of the flavonoid quercetin (150 μmol/kg body wt/day intraperitoneally) in rats with carbon tetrachloride-induced fibrosis. In animals rendered cirrhotic by administration of carbon tetrachloride for 16 weeks, cell necrosis, fibrosis, and inflammatory infiltration were found. Histological abnormalities were accompanied by a higher hepatic content of collagen and thiobarbituric acid-reactive substances. Expression of inducible nitric oxide synthase (iNOS) was significantly increased in the liver. Treatment with quercetin during 3 weeks improved liver histology and reduced collagen content, iNOS expression, and lipid peroxidation. Those effects were associated with an increased total peroxyl radical-trapping antioxidant capacity of liver. We conclude that quercetin is effective in this model of liver damage.

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Authors and Affiliations

  1. ULBRA-Cachoeira do Sul e Canoas, Brasil

    Amalia Pavanato & Norma Marroni

  2. Department of Physiology, University of León, Léon, Spain

    María J. Tuñón, Sonia Sánchez-Campos & Javier González-Gallego

  3. Faculdad Federal de Ciências Médicas de Porto Alegre, Brasil

    Claudio A. Marroni

  4. Pharmacy and Biochemistry School, University of Buenos Aires, Argentina

    Susana Llesuy

Authors
  1. Amalia Pavanato
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  2. María J. Tuñón
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  3. Sonia Sánchez-Campos
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  4. Claudio A. Marroni
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  5. Susana Llesuy
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  6. Javier González-Gallego
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  7. Norma Marroni
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Pavanato, A., Tuñón, M.J., Sánchez-Campos, S. et al. Effects of Quercetin on Liver Damage in Rats with Carbon Tetrachloride-Induced Cirrhosis. Dig Dis Sci 48, 824–829 (2003). https://doi.org/10.1023/A:1022869716643

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