Abstract
[NiFe] hydrogenases are well-characterized enzymes that have a key function in the H2 metabolism of various microorganisms. In the recent years a subfamily of [NiFe] hydrogenases with unique properties has been identified. The members of this family form multisubunit membrane-bound enzyme complexes composed of at least four hydrophilic and two integral membrane proteins. These six conserved subunits, which built the core of these hydrogenases, have closely related counterparts in energy-conserving NADH:quinone oxidoreductases (complex I). However, the reaction catalyzed by these hydrogenases differs significantly from the reaction catalyzed by complex I. For some of these hydrogenases the physiological role is to catalyze the reduction of H+ with electrons derived from reduced ferredoxins or polyferredoxins. This exergonic reaction is coupled to energy conservation by means of electron-transport phosphorylation. Other members of this hydrogenase family mainly function to provide the cell with reduced ferredoxin with H2 as electron donor in a reaction driven by reverse electron transport. As complex I these hydrogenases function as ion pumps and have therefore been designated as energy-converting [NiFe] hydrogenases.
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Albracht, S. P., and Hedderich, R. (2000). FEBS Lett. 485, 1-6.
Albracht, S. P. J. (1994). Biochim. Biophys. Acta 1188, 167-204.
Andrews, S. C., Berks, B. C., McClay, J., Ambler, A., Quail, M. A., Golby, P., and Guest, J. R. (1997). Microbiology 143, 3633-3647.
Bao, Q., Tian, Y., Li, W., Xu, Z., Xuan, Z., Hu, S., Dong, W., Yang, J., Chen, Y., Xue, Y., Xu, Y., Lai, X., Huang, L., Dong, X., Ma, Y., Ling, L., Tan, H., Chen, R., Wang, J., Yu, J., and Yang, H. (2002). Genome Res. 12, 689-700. f
Bertram, P. A., and Thauer, R. K. (1994). Eur. J. Biochem. 226, 811-818.
Blokesch, M., Paschos, A., Theodoratou, E., Bauer, A., Hube, M., Huth, S., and Bock, A. (2002). Biochem. Soc. Trans. 30, 674-680.
Bock, A. K., Kunow, J., Glasemacher, J., and Schönheit, P. (1996). Eur. J. Biochem. 237, 35-44.
Böhm, R., Sauter, M., and Böck, A. (1990). Mol. Microbiol. 4, 231-243.
Bonam, D., and Ludden, P. W. (1987). J. Biol. Chem. 262, 2980-2987.
Bott, M., Eikmanns, B., and Thauer, R. K. (1986). Eur. J. Biochem. 159, 393-398.
Bott, M., and Thauer, R. K. (1989). Eur. J. Biochem. 179, 469-472.
Brandt, U., Kerscher, S., Drose, S., Zwicker, K., and Zickermann, V. (2003). FEBS Lett. 545, 9-17.
Bult, C. J., White, O., Olsen, G. J., Zhou, L., Fleischmann, R. D., Sutton, G. G., Blake, J. A., FitzGerald, L. M., Clayton, R. A., Gocayne, J. D., Kerlavage, A. R., Dougherty, B. A., Tomb, J. F., Adams, M. D., Reich, C. I., Overbeek, R., Kirkness, E. F., Weinstock, K. G., Merrick, J. M., Glodek, A., Scott, J. L., Geoghagen, N. S. M., and Venter, J. C. (1996). Science 273, 1058-1073.
Darrouzet, E., Issartel, J. P., Lunardi, J., and Dupuis, A. (1998). FEBS Lett. 431, 34-38.
Deppenmeier, U., Müller, V., and Gottschalk, G. (1996). Arch. Microbiol. 165, 149-163.
Dobbek, H., Svetlitchnyi, V., Gremer, L., Huber, R., and Meyer, O. (2001). Science 293, 1281-1285.
Drennan, C. L., Heo, J., Sintchak, M. D., Schreiter, E., and Ludden, P. W. (2001). Proc. Natl. Acad. Sci. U.S.A. 98, 11973-11978.
Ensign, S. A., and Ludden, P. W. (1991). J. Biol. Chem. 266, 18395-18403.
Ferry, J. G. (1997). Biofactors 6, 25-35.
Fox, J. D., He, Y., Shelver, D., Roberts, G. P., and Ludden, P. W. (1996b). J. Bacteriol. 178, 6200-6208.
Fox, J. D., Kerby, R. L., Roberts, G. P., and Ludden, P. W. (1996a). J. Bacteriol. 178, 1515-1524.
Friedrich, T., and Scheide, D. (2000). FEBS Lett. 479, 1-5.
Friedrich, T., and Weiss, H. (1997). J. Theor. Biol. 187, 529-540.
Garcin, E., Montet, Y., Volbeda, A., Hatchikian, C., Frey, M., and Fontecilla-Camps, J. C. (1998). Biochem. Soc. Trans. 26, 396-401.
Hamamoto, T., Hashimoto, M., Hino, M., Kitada, M., Seto, Y., Kudo, T., and Horikoshi, K. (1994). Mol. Microbiol. 14, 939-946.
Ingledew, W. J., and Ohnishi, T. (1980). Biochem. J. 186, 111-117.
Kaesler, B., and Schönheit, P. (1989a). Eur. J. Biochem. 184, 223-232.
Kaesler, B., and Schönheit, P. (1989b). Eur. J. Biochem. 186, 309-316.
Kashani-Poor, N., Zwicker, K., Kerscher, S., and Brandt, U. (2001). J. Biol. Chem. 276, 24082-24087.
Kerby, R. L., Hong, S. S., Ensign, S. A., Coppoc, L. J., Ludden, P. W., and Roberts, G. P. (1992). J. Bacteriol. 174, 5284-5294.
Kerby, R. L., Ludden, P. W., and Roberts, G. P. (1995). J. Bacteriol. 177, 2241-2244.
Kerby, R. L., Ludden, P. W., and Roberts, G. P. (1997). J. Bacteriol. 179, 2259-2266.
Künkel, A., Vorholt, J. A., Thauer, R. K., and Hedderich, R. (1998). Eur. J. Biochem. 252, 467-476.
Kurkin, S., Meuer, J., Koch, J., Hedderich, R., and Albracht, S. P. (2002). Eur. J. Biochem. 269, 6101-6111.
Malki, S., Saimmaime, I., De Luca, G., Rousset, M., Dermoun, Z., and Belaich, J. P. (1995). J. Bacteriol. 177, 2628-2636.
Meuer, J., Bartoschek, S., Koch, J., Künkel, A., and Hedderich, R. (1999). Eur. J. Biochem. 265, 325-335.
Meuer, J., Kuettner, H. C., Zhang, J. K., Hedderich, R., and Metcalf, W. W. (2002). Proc. Natl. Acad. Sci. U.S.A. 99, 5632-5637.
Nicolet, Y., Cavazza, C., and Fontecilla-Camps, J. C. (2002). J. Inorg. Biochem. 91, 1-8.
Putnoky, P., Kereszt, A., Nakamura, T., Endre, G., Grosskopf, E., Kiss, P., and Kondorosi, A. (1998). Mol. Microbiol. 28, 1091-1101.
Sapra, R., Bagramyan, K., and Adams, M. W. (2003). Proc. Natl. Acad. Sci. U.S.A. 100, 7545-7550.
Sapra, R., Verhagen, M., and Adams, M. W. W. (2000). J. Bacteriol. 182, 3423-3428.
Sauter, M., Böhm, R., and Böck, A. (1992). Mol. Microbiol. 6, 1523-1532.
Schwarz, E., and Friedrich, B. (2003). In The Prokaryotes: An Evolving Electronic Resource for the Microbiological Community (Dworkin, M., ed.), Springer, New York. Retrieved from http://141.150.157.117:8080/prokPUB/index.htm
Shelver, D., Kerby, R. L., He, Y., and Roberts, G. P. (1997). Proc. Natl. Acad. Sci. U.S.A. 94, 11216-11220.
Silva, P. J., van den Ban, E. C., Wassink, H., Haaker, H., de Castro, B., Robb, F. T., and Hagen, W. R. (2000). Eur. J. Biochem. 267, 6541-6551.
Skibinski, D. A., Golby, P., Chang, Y. S., Sargent, F., Hoffman, R., Harper, R., Guest, J. R., Attwood, M. M., Berks, B. C., and Andrews, S. C. (2002). J. Bacteriol. 184, 6642-6653.
Slesarev, A. I., Mezhevaya, K. V., Makarova, K. S., Polushin, N. N., Shcherbinina, O. V., Shakhova, V. V., Belova, G. I., Aravind, L., Natale, D. A., Rogozin, I. B., Tatusov, R. L., Wolf, Y. I., Stetter, K. O., Malykh, A. G., Koonin, E. V., and Kozyavkin, S. A. (2002). Proc. Natl. Acad. Sci. U.S.A. 99, 4644-4649.
Soboh, B., Linder, D., and Hedderich, R. (2002). Eur. J. Biochem. 269, 5712-5721.
Svetlichny, V. A., Sokolova, T. G., Gerhardt, M., Ringpfeil, M., Kostrikina, N. A., and Zavarzin, G. A. (1991). Syst. Appl. Microbiol. 14, 254-260.
Svetlitchnyi, V., Peschel, C., Acker, G., and Meyer, O. (2001). J. Bacteriol. 183, 5134-5144.
Tersteegen, A., and Hedderich, R. (1999). Eur. J. Biochem. 264, 930-943.
Thauer, R. K. (1998). Microbiology 144, 2377-2406.
Thauer, R. K., Klein, A. R., and Hartmann, G. C. (1996). Chem. Rev. 96, 3031-3042.
Tran-Betcke, A., Warnecke, U., Bocker, C., Zaborosch, C., and Friedrich, B. (1990). J. Bacteriol. 172, 2920-2929.
Uffen, R. L. (1976). Proc. Natl. Acad. Sci. U.S.A. 73, 3298-3302.
Vignais, P. M., Billoud, B., and Meyer, J. (2001). FEMS Microbiol. Rev. 25, 455-501.
Volbeda, A., Charon, M. H., Piras, C., Hatchikian, E. C., Frey, M., and Fontecilla-Camps, J. C. (1995). Nature 373, 580-587.
Vorholt, J. A., Vaupel, M., and Thauer, R. K. (1996). Eur. J. Biochem. 236, 309-317.
Winner, C., and Gottschalk, G. (1989). FEMS Microbiol. Lett. 65, 259-264.
Xue, Y., Xu, Y., Liu, Y., Ma, Y., and Zhou, P. (2001). Int. J. Syst. Evol. Microbiol. 51, 1335-1341.
Yagi, T., Yano, T., Di Bernardo, S., and Matsuno-Yagi, A. (1998). Biochim. Biophys. Acta 1364, 125-133.
Yano, T., and Ohnishi, T. (2001). J. Bioenerg. Biomembr. 33, 213-222.
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Hedderich, R. Energy-Converting [NiFe] Hydrogenases from Archaea and Extremophiles: Ancestors of Complex I. J Bioenerg Biomembr 36, 65–75 (2004). https://doi.org/10.1023/B:JOBB.0000019599.43969.33
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DOI: https://doi.org/10.1023/B:JOBB.0000019599.43969.33